DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rok and lats2

DIOPT Version :9

Sequence 1:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_001116779.1 Gene:lats2 / 567674 ZFINID:ZDB-GENE-050119-6 Length:1140 Species:Danio rerio


Alignment Length:540 Identity:169/540 - (31%)
Similarity:254/540 - (47%) Gaps:134/540 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 ETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKY 70
            |.|.|.....:.||.:   ||:||.               .|.:|:.:.|.:|::  :.|..:.|
Zfish   651 ENVMKTYQQKLNRRMQ---LEQEMS---------------KAGLSEAEQEQMRKM--LYQKESNY 695

  Fly    71 KPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEE 135
            .    ::.:.:|:...|..||.:|.||||||.|.|...:..:||||.|.|.:::.|...|....|
Zfish   696 N----RLRRAKMDKSMFVKIKTLGIGAFGEVCLTRKVDTGALYAMKTLRKKDVLNRNQVAHVKAE 756

  Fly   136 RHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSL---MGDYDIPEKWAIFYTMEVVLAL 197
            |.|:|.|::||:|:|:::|||...||.|||::||||::||   ||.:  ||..|.||..|:.||:
Zfish   757 RDILAEADNEWVVRLYYSFQDRDNLYFVMDYIPGGDMMSLLIRMGVF--PEVLARFYVAELTLAI 819

  Fly   198 DTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC------------------------------- 231
            :::|.|||:|||:||||:|:|..||:||.|||.|                               
Zfish   820 ESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPSDSWDD 884

  Fly   232 ---MRMG------------ANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYE 281
               .|.|            .:.:.::.:.||||:||:||||..:|    |.:.|||||||:.|:|
Zfish   885 VSNCRCGDRLMTLEQRATRQHQRCLAHSLVGTPNYIAPEVLLRKG----YTQLCDWWSVGVILFE 945

  Fly   282 MLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAH 346
            ||.|:.||.|.:......|:::.:|:|..||:|::|.:|..:|........:|||..|..:||||
Zfish   946 MLVGQPPFLAPTPTEAQLKVINWENTLQVPPQVKLSPEAVDIIGQLCCSAEERLGGNGAGEIKAH 1010

  Fly   347 PFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD------------------------EK 387
            |||....:| .|:|....|..|:::...||.||:.:|.:                        :.
Zfish  1011 PFFSEVDFS-SNLRTQPAPYRPKIAHPMDTSNFDPVEEEGGPGAWSDSGDSTRTWDTLCSPHGKH 1074

  Fly   388 PEEV---FPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRH 449
            ||..   |...:.||.|..||                  ...|......|.::|:..|       
Zfish  1075 PEHAFYEFTFRRFFDDNGCPF------------------RYPKPLEATQSLSSSDGAG------- 1114

  Fly   450 RPSNSNELKRLEALLERERG 469
              |...||:..||..|.|:|
Zfish  1115 --SLKPELEEEEAHEEEEQG 1132

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 144/425 (34%)
S_TKc 87..349 CDD:214567 121/310 (39%)
SbcC 484..1088 CDD:223496
Rho_Binding 963..1027 CDD:286056
PH_ROCK 1134..1250 CDD:269948
C1 1254..1307 CDD:197519
lats2NP_001116779.1 UBA_LATS2 105..145 CDD:270581
Med15 175..>635 CDD:255446
PKc_like 706..1088 CDD:304357 136/388 (35%)
S_TKc 708..1013 CDD:214567 121/310 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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