DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and CDC42BPG

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_011543457.1	Gene:	CDC42BPG / 55561	HGNCID:	29829	Length:	1569	Species:	Homo sapiens

Alignment Length:	1530	Identity:	407/1530 - (26%)
Similarity:	627/1530 - (40%)	Gaps:	516/1530 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VERRRRANTLEREMRDPTSIC-NVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQ 79
            :|||.||  ||:..|.....| .:|.|||.:.||..:.....|||.:::.|:.:...|...::.:
Human     1 MERRLRA--LEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSKVKE 63

  Fly    80 LRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANS 144
            ||:..:||..:|:||.||||||.:||.:.:.|::|||.|.|:||:||.::|.|.|||.::...:|
Human    64 LRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDS 128

  Fly   145 EWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVH 207
            .|:..||:||||.:|||:|||:..|||:::|:..::  :|.:.|.||..|:|||:.::|.:|:||
Human   129 RWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVH 193

  Fly   208 RDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS--QGVDNEYGREC 270
            |||||||:|||..||::|||||:|:|:..||.|.||.|||||||||||:||:  :| ...||.:|
Human   194 RDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEG-KGHYGPQC 257

  Fly   271 DWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQR 334
            ||||:|:..||:|||||||||:|||.||||||:|::.|.|||:| ::...|:.|||..|..:.:|
Human   258 DWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQLLCRQEER 322

  Fly   335 LGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD--EKPEEVFPVPKG 397
            |||.|::|.:.||||....|  :.:..|..|.:|||....||.|| |::.|  ..|..:.|...|
Human   323 LGRGGLDDFRNHPFFEGVDW--ERLASSTAPYIPELRGPMDTSNF-DVDDDTLNHPGTLPPPSHG 384

  Fly   398 -FDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLE 461
             |.|:||||:|||||                      ||:            |.|.:|:|   ..
Human   385 AFSGHHLPFVGFTYT----------------------SGS------------HSPESSSE---AW 412

  Fly   462 ALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQE-IE 525
            |.|||:                                                 :|.:||| :|
Human   413 AALERK-------------------------------------------------LQCLEQEKVE 428

  Fly   526 L-RKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAEL 589
            | ||..|||...|...                          |:||           |:|
Human   429 LSRKHQEALHAPTDHR--------------------------ELEQ-----------LRK----- 451

  Fly   590 DFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKE-AENKMQTLI 653
                     :|:.:.|.:..:.:.|..|.|.:........|:.:||.:|..:|:| ||.:..  :
Human   452 ---------EVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAG--L 505

  Fly   654 NDIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREE 718
            ...|:.:||.|..||:   ||:::.:.::                                 ||.
Human   506 QAQEQELCRAQGQQEE---LLQRLQEAQE---------------------------------REA 534

  Fly   719 ANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRL-QKLEGECR-------- 774
            |...:.:||.|:|.|.::|:       :|.|.|:|.||....|:|.:. |:||...:
Human   535 ATASQTRALSSQLEEARAAQ-------RELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTAS 592

  Fly   775 ------------QESE---KVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQ-LQKELS 823
                        ||::   :||||:.||:|.||.|.:...|......|.....|||.: |:.||:
Human   593 ETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELA 657

  Fly   824 TQREAKRRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERLSKIEDL 888
            .::|:|:|.|              ...||.::..||                 :.|:.||.:.|
Human   658 QEQESKQRLE--------------GERRETESNWEA-----------------QLADILSWVND- 690

  Fly   889 EEERVSLKHQVQVAVARADSEALARSIAEETV-----------ADLEKEKTIKELELKDFVMKHR 942
              |:||..:...:|...|:.....|::..:|:           ..|:|.:....|||:..:   .
Human   691 --EKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSAL---E 750

  Fly   943 NEINAKEA---ALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDK 1004
            .||.||:.   .|..::||:.:..::|       ::..:|.:..|:|||::|    ||:     :
Human   751 AEIRAKQGLQERLTQVQEAQLQAERRL-------QEAEKQSQALQQELAMLR----EEL-----R 799

  Fly  1005 CKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLL 1069
            .:..|..|  ..|.|...::.|.|:....|:...|....|
Human   800 ARGPVDTK--PSNSLIPFLSFRSSEKDSAKDPGISGEATR------------------------- 837

  Fly  1070 KHQDLQQLCAE-EQQLKQKMVM--EIDCKATEIENLQSK---LNETASLSSADNDPEDSQH---- 1124
             |.....|..| .:.|:...|.  .........|.|.:|   :....:|.:....|:...|
Human   838 -HGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKGWGMGPWEALGNGCPPPQPGSHTLRP 901

  Fly  1125 -------------SSLLSLTQD------------------------------------------S 1134
                         |.:|.|.:.                                          :
Human   902 RSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGT 966

  Fly  1135 VFEGWLSVPNKQNRRRGHGWKRQYVIVS-SRKIIFYNSDIDKHNTTDAVL-ILDL-SKVYHVRSV 1196
            .:||:||||.....||  ||:|.:..:| ||.::|...|:.....:.|:| :||| ...:....|
Human   967 AYEGFLSVPRPSGVRR--GWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPV 1029

  Fly  1197 TQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITY 1261
            ...|||.|.::::||||::            ..|||.|.
Human  1030 LASDVIHAQSRDLPRIFRV------------TTSQLAVP-------------------------- 1056

  Fly  1262 HMPTACEVC-----------------------------PKPLWHMFKPPAAYECKRCRNKIHKEH 1297
              ||.|.|.                             |:|::.:                 ||.
Human  1057 --PTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTL-----------------KEA 1102

  Fly  1298 VDKHDPLAP---CKLNHDPRSARDMLLLAATPEDQSLWVARL----------LKRIQK------S 1343
            .|...||.|   |....|    :|.|.|..   ::.|:|..|          .:|:|:      :
Human  1103 YDNGLPLLPHTLCAAILD----QDRLALGT---EEGLFVIHLRSNDIFQVGECRRVQQLTLSPSA 1160

  Fly  1344 G--------------YKAASYNNNSTDGSKISPSQ 1364
            |              :..|...|....|:||..|:
Human  1161 GLLVVLCGRGPSVRLFALAELENIEVAGAKIPESR 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	173/357 (48%)
		S_TKc	87..349	CDD:214567	142/266 (53%)
		SbcC	484..1088	CDD:223496	131/646 (20%)
		Rho_Binding	963..1027	CDD:286056	13/63 (21%)
		PH_ROCK	1134..1250	CDD:269948	34/118 (29%)
		C1	1254..1307	CDD:197519	12/84 (14%)
CDC42BPG	XP_011543457.1	STKc_DMPK_like	69..399	CDD:270748	169/333 (51%)
		S_TKc	71..337	CDD:214567	142/266 (53%)
		TPH	410..802	CDD:290579	123/592 (21%)
		DMPK_coil	744..801	CDD:117396	18/75 (24%)
		C1_1	897..>939	CDD:278556	4/41 (10%)
		PH_MRCK	956..1088	CDD:269949	38/173 (22%)
		CNH	1115..1378	CDD:279162	17/88 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820