DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rok and lats1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001018346.1	Gene:	lats1 / 553164	ZFINID:	ZDB-GENE-050523-2	Length:	1068	Species:	Danio rerio

Alignment Length:	446	Identity:	152/446 - (34%)
Similarity:	227/446 - (50%)	Gaps:	85/446 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKY 70
            |.:.|...   :|.||...||.||:.              ..|..|. .|.:|.:  :.|..:.|
Zfish   588 ENILKNHQ---QRMRRKKQLESEMQR--------------VGLSGDA-QEQMRMM--LSQKESNY 632

  Fly    71 KPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEE 135
                :::.:.:|:...|..||.:|.||||||.|.|...:..:||||.|.|.:::.|...|....|
Zfish   633 ----IRLKRAKMDKCMFEKIKTLGIGAFGEVCLARKVDTGALYAMKTLRKKDVLLRNQVAHVKAE 693

  Fly   136 RHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSL---MGDYDIPEKWAIFYTMEVVLAL 197
            |.|:|.|::||:|:|:::|||...||.|||::||||::||   ||.:.  |..|.||..|::.|:
Zfish   694 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFQ--EDLAQFYIAELICAV 756

  Fly   198 DTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC------------------------------- 231
            :::|.|||:|||:||||:|:|..||:||.|||.|
Zfish   757 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHVRQDSMDFSMEWED 821

  Fly   232 ---MRMG------------ANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYE 281
               .|.|            .:.:.::.:.||||:||:||||...|    |.:.|||||||:.|||
Zfish   822 SANCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----YTQLCDWWSVGVILYE 882

  Fly   282 MLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAH 346
            |:.|:.||.|.:.:.|..|::..:.||..|.:.::|.:|..||.........||||.|.::|||.
Zfish   883 MVVGQPPFLATTPLETQMKVIRWQTSLHIPLQAKLSPEATDLILKLCRGPDDRLGRNGADEIKAQ 947

  Fly   347 PFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNH 402
            ||||....|.|..::...|.:|:::...||.||:.::.|:...|      ..||||
Zfish   948 PFFRTIDLSKDLRQQHQAPYIPKITHSTDTSNFDPVDPDKLWSE------DADGNH 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	139/391 (36%)
		S_TKc	87..349	CDD:214567	119/310 (38%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
lats1	NP_001018346.1	PKc_like	644..1024	CDD:304357	136/366 (37%)
lats1	NP_001018346.1	S_TKc	645..950	CDD:214567	119/310 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920