Protein Alignment Rok and sti

DIOPT Version :9

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_001261768.1
• Gene: sti / 39429
• FlyBaseID: FBgn0002466
• Length: 1858
• Species: Drosophila melanogaster
• Alignment Length: 1516
• Identity: 386/1516 - (25%)
• Similarity: 681/1516 - (44%)
• Gaps: 352/1516 - (23%)

  Fly    34 SICNVDCLLDTVSALVSDCDHESL-RRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGA 97
            :||. :.|||....|.::||.::| :|.:||.::..|::|:..:..:||:|.:||....|||.|.
  Fly    60 AICR-EGLLDAFCLLYNECDKDTLKKRDRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGY 123

  Fly    98 FGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYM 162
            ||.|.||..:.::.:||||::.|..:    .::...|||.||:..||||::.|.:||||...||:
  Fly   124 FGNVHLVVERQTNDIYAMKKIKKSVV----TTSQVKEERDIMSIRNSEWLINLQYAFQDNDNLYL 184

  Fly   163 VMDFMPGGDIVSLM---GDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLK 224
            ||::|||||::|||   |.:|  |..|.||..|:.:||.|:|.||:||||:||:|:|:|.:||:|
  Fly   185 VMEYMPGGDLLSLMSRHGPFD--EDLARFYLAELTVALHTLHEMGYVHRDIKPENILIDRFGHIK 247

  Fly   225 LADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQ-------SQGVDNEYGR--ECDWWSVGIFLY 280
            |||||....:..:|.|:|.:.|||||||:||:||       |:.: ::..|  .||:||:||..|
  Fly   248 LADFGNAAALDRDGHVLSLSPVGTPDYIAPELLQTISTYKLSKSM-HDVSRIVSCDYWSMGIIGY 311

  Fly   281 EMLFGETPFYADSLVGTYGKIMDH------KNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYG 339
            |::...|||:.|::..||.||:.|      |..:|||.::::|...:.||.:.:|:.::||   .
  Fly   312 ELICETTPFHEDNVHETYSKILSHCEESHLKELISFPADLKVSVNYRNLIESLVTNPSKRL---S 373

  Fly   340 IEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKG------- 397
            .|.||.||||....|.  :||..|||::|.:.|||||.||||..|.:...|.....|.
  Fly   374 YERIKNHPFFSEIPWG--SIRSQVPPIIPTVRSDDDTSNFEDGIRHKTRREQGVAKKSLTTNMKS 436

  Fly   398 --FDGNHLPFIGFTYT------------------------------GDYQLLSSDTVDA------ 424
              |.|..|||||:::.                              .:..:|..|.:.|
  Fly   437 NDFSGKDLPFIGYSFVHMEKSAISATTDEKLQEKLKELLQKLKTRENEISMLKQDLLRAQQSLRK 501

  Fly   425 -ESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQI--- 485
             ::|...||::                   ..|:|:|:.:::.:.......:.|...|:...
  Fly   502 TDNKSQVVADA-------------------KMEIKKLQQIIKEKTMELTTCKTQIKTLQSSAKID 547

  Fly   486 -ELITKREA-------------ELQRIASE--YEKDLALRQHNYKVAMQKVE-QEIELRKKTEA- 532
             |:.:|:||             |..:||||  |||.||.::......:||:: :|:|...|.|.
  Fly   548 EEMWSKKEATITDLLRLNRQKYEEAKIASEQRYEKQLADKKQELASTLQKLDARELEFNAKFEEC 612

  Fly   533 --LLVETQ-----------RNLEN-----EQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENT 579
              |.::.|           :||::     ||:.:..:| ...|:..|.|   ::..|..|....|
  Fly   613 KHLSMKLQNYKDMLQQIKEQNLKSETNHEEQRRQMAEL-YEQKLTDLRK---KVRDSQDTNRRMT 673

  Fly   580 QKLKKHNAELDFTVKS----QEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKE 640
            .::|:...|||.::.|    ||.|.....::.:.|::..||:...| ||.|..|:.:. :.||||
  Fly   674 MEIKEIRTELDESISSSKSTQEAKNATERNIEEILRRLNEEIASNN-ELHAEKVKLET-KLQLKE 736

  Fly   641 MH-KEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKA 704
            .. :|...:...|..:::...||.|.|:.   :|..::|..|.|...|. ||.|.:.:.:.::.|
  Fly   737 NETQEVRAECHRLERELQLAECRCQLAES---SLATQVSPYETAPGSLT-ELNAIEDQLRADLLA 797

  Fly   705 HQETEKSRLVSREEANLQEVKALQSKL-------NEEKSARIKADQHS---QEKERQLSMLSVDY 759
            .:|:|     :.::....:::.|.:||       ||:..:..|:  ||   ||.|....||....
  Fly   798 AKESE-----NHQKGRADQLQTLVTKLEQMLERFNEQSLSPTKS--HSSRKQEGETVGDMLERQN 855

  Fly   760 RQIQLRLQKLEGE--CRQESEKVAAL-----QSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQ 817
            .:::.:|..:..:  ..:::.:.|.|     :.||::..|::..|...:.|....:..:::..::
  Fly   856 EKLEDKLAAVREQMIVERQAARTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDE 920

  Fly   818 LQKELSTQREAKR----RFEEDLTQLKSTHHEALANNRELQ-AQLEAEQCFSRLYKTQANENREE 877
            .|:.|.|.:|..|    |.||...:|.:...:.|..:|:.: |:.|..:|            :.|
  Fly   921 AQRMLKTSQEETRQRESRIEELKQELAAAKRDVLKEHRQWEKAEQERMKC------------KSE 973

  Fly   878 SAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADL--EKEKTIK--------EL 932
            ..|.|:.:..||::...|:.:::...:|.|...|.:   :.|:.:|  |:||:.|        :.
  Fly   974 IIEHLANVHRLEQQETELRQKLRQIQSRFDGVTLEQ---KNTIRELQEEREKSRKANDSCLVLQK 1035

  Fly   933 ELKDFV-----MKHRNEI-NAKEAALATLKEAENE-----------LHKKLGQKAAEYEDL---- 976
            |||...     :|:...| :::...:.|:.::|.|           ||:||.::..:..||
  Fly  1036 ELKQLTDNFQRLKYACSITDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQLTDLRKQL 1100

  Fly   977 --VQQHKKQQEELALMRSSKDEEITKLLDKCKNEVLLKQ----------VAVNKLAEVMNRRDSD 1029
              |:..|:..|:.|.:.:|:.:|:...|.:.:.:::.:|          .|..:.||:::.::::
  Fly  1101 TTVESEKRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFATQERAELLDGQNAN 1165

  Fly  1030 LPKQ------------KNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQDLQQLCAEEQ 1082
            ...|            :..||..:||..|::|:..||.|:.........|..:...||...||::
  Fly  1166 YEAQTADSNREMVSLKEENARILSELFHKKEEVGNLQAEIRGLESAQANLHAEIDSLQDTLAEKE 1230

  Fly  1083 Q------LKQKMVME-----IDCKATEIENLQSKLNET-------ASLSSADN-DPEDSQHSSLL 1128
            |      :|....:.     ||....::|:|.:|..:|       :|.::.:| .|.|.:.|.|.
  Fly  1231 QFYVQRDIKSNATLAQHKKLIDYLQLKVEDLSAKKKKTLADKLFGSSHTNKENVSPNDVESSILY 1295

  Fly  1129 SLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHV 1193
            ...::.:                   ||:                .|.|:.....:..|:....:
  Fly  1296 RALKEEL-------------------KRE----------------QKMNSLLKEQLAQLNGTATL 1325

  Fly  1194 RSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQ------SQLDVSVLHGNCNEERPG--TIV 1250
            ||..:...:..|: :.|:...:..|....|.:..:|      ||:::..     ..|:|.  ||.
  Fly  1326 RSPRKSAAVNGDS-DAPKQRPVSIAALPRSPQKQQQPLKRTTSQVELKT-----TAEKPTKVTIE 1384

  Fly  1251 HKGHEFVHITYHMPTA----CEVCPK------PLWHMFKPPAAYECKRCRNKIHKE-------HV 1298
            ::.|....:.......    |.||.|      |.|         :||.|::..|::       |.
  Fly  1385 NQAHHRFELALQESKVDAVNCVVCEKAVVAGSPFW---------KCKECKDVTHRKCRSNVQSHC 1440

  Fly  1299 DKHDPLAPCKLNHDPRSARDM 1319
            ....|.||        ||.|:
  Fly  1441 GSTKPTAP--------SADDL 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	155/376 (41%)
		S_TKc	87..349	CDD:214567	119/279 (43%)
		SbcC	484..1088	CDD:223496	162/730 (22%)
		Rho_Binding	963..1027	CDD:286056	16/79 (20%)
		PH_ROCK	1134..1250	CDD:269948	17/123 (14%)
		C1	1254..1307	CDD:197519	14/69 (20%)
sti	NP_001261768.1	PKc_like	111..452	CDD:304357	148/352 (42%)
		S_TKc	113..383	CDD:214567	119/279 (43%)
		Smc	487..1222	CDD:224117	167/785 (21%)
		CNH	1503..1774	CDD:279162

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442198
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D6806at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22988
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850