DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Stk38

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006256201.2	Gene:	Stk38 / 361813	RGDID:	1309455	Length:	465	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	168/453 - (37%)
Similarity:	247/453 - (54%)	Gaps:	73/453 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RETVTKQRSMDVERRRRANTLEREMRDP--TSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYA 67
            |.|:||....:......|...|||||..  ..:...:.|.|         :.:.|||..:
  Rat    19 RVTMTKVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKD---------EEKRLRRSAH----- 69

  Fly    68 AKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFF 132
            |:.:...:::.:.|:.:|||..:|:||.||||||:||:.|.:..|||||.|.|.:|:::......
  Rat    70 ARKETEFLRLKRTRLGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHI 134

  Fly   133 WEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD-IPEKWAIFYTMEVVLA 196
            ..||.|:..|:|.|:|::.::|||...||::|:|:||||:::|:...| :.|:...||..|.|||
  Rat   135 RAERDILVEADSLWVVRMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLA 199

  Fly   197 LDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC-------------------------MRMGA 236
            :|:||.:||:|||:||||:||||.||:||:|||.|                         ..|.:
  Rat   200 IDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 264

  Fly   237 ---------NGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYAD 292
                     |.:.::.:.|||||||:|||....|    |.:.|||||:|:.:||||.|..||.::
  Rat   265 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTG----YNKLCDWWSLGVIMYEMLIGYPPFCSE 325

  Fly   293 SLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFD 357
            :...||.|:|:.|.:|:|||||.:||:||.||..|..:...|:|..|:|:||::|||....|  :
  Rat   326 TPQETYKKVMNWKETLTFPPEVPVSEKAKGLILRFCCEWEHRIGAPGVEEIKSNPFFEGVDW--E 388

  Fly   358 NIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLP----------FIGFTY 410
            :|||....:..|:.|.|||.||     ||.||.....|.....|| |          ||.:||
  Rat   389 HIRERPAAISIEIKSIDDTSNF-----DEFPESDILKPTVTTSNH-PETDYKSKDWVFINYTY 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	153/395 (39%)
		S_TKc	87..349	CDD:214567	124/296 (42%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Stk38	XP_006256201.2	STKc_NDR1	87..462	CDD:270777	151/371 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920