DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Rok and rock2a

DIOPT Version :9

Sequence 1:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_777288.1 Gene:rock2a / 317747 ZFINID:ZDB-GENE-030115-3 Length:1375 Species:Danio rerio


Alignment Length:1410 Identity:620/1410 - (43%)
Similarity:880/1410 - (62%) Gaps:103/1410 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SMDVERR--RRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAM 75
            |:..|||  .|...||..::||.|..|::.|||:::|||.|.|..:||:.||||.:..:|:.:..
Zfish     2 SLGAERRMENRLRQLEAMIKDPRSAINLESLLDSMNALVLDLDFPALRKNKNIENFLNRYEKVMN 66

  Fly    76 QINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMA 140
            .|.:|:|..|||..:|:||.||||||||||||:|.:|||||.||||||:||.|||||||||.|||
Zfish    67 HIRELQMRPEDFDRVKVIGRGAFGEVQLVRHKASQKVYAMKVLSKFEMIKRSDSAFFWEERDIMA 131

  Fly   141 HANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGF 205
            .|:|.|:|||..||||.:.|||||::|||||:|:|...||:|||||.|||.|||||||.||:|||
Zfish   132 FADSPWVVQLCCAFQDDRSLYMVMEYMPGGDLVNLTSTYDVPEKWAKFYTAEVVLALDAIHSMGF 196

  Fly   206 VHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGREC 270
            :||||||||||||.|||||||||||||:|...|.|....|||||||||||||:|||.|..|||||
Zfish   197 IHRDVKPDNMLLDRYGHLKLADFGTCMKMDGTGMVHCDTAVGTPDYISPEVLKSQGGDGYYGREC 261

  Fly   271 DWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRL 335
            ||||||:|:||||.|:||||||||||||.|||||||||:||.:||||::.|.:|.||||||..||
Zfish   262 DWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDHKNSLNFPDDVEISQEGKNIICAFLTDREVRL 326

  Fly   336 GRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDG 400
            ||.|:|:||.|||||||.|:|..|||:..|||||||||.||.||::||.|:...|.||.||.|.|
Zfish   327 GRSGVEEIKRHPFFRNDQWTFSTIRETAAPVVPELSSDIDTSNFDEIEEDKGEVETFPTPKAFVG 391

  Fly   401 NHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLE 465
            |.|||:||||..:.|||            |..||.|..|:|... |.....:...:|..||..|.
Zfish   392 NQLPFVGFTYFKENQLL------------NAVNSSAMKNDHPVS-NREDNLALQKKLHCLEEQLN 443

  Fly   466 RERGRSEALEQQDAGLRQQIELITKREAE-------LQRIASEYEKDLALRQHNYKVAMQKVEQE 523
            .|....:.|||:......::|.|||...|       |:....:.|::.||.||....:.::.|.|
Zfish   444 NEMQAKDELEQKYRSNSNRLEKITKELDEEMNSRKGLESTLRQLEREKALLQHKSVESHRRAESE 508

  Fly   524 IELRKKTEALLVETQRNLENEQKTRARDLNI-NDKVVSLEKQLLEMEQSYKTETENTQKLKKHNA 587
            .: ||:.....|.:.|:..:|.|.:.::.:| |:|.:.|:|||.|.....:.|:|...:::|...
Zfish   509 AD-RKRCLENEVNSLRDQLDEMKKKNQNSHISNEKNIHLQKQLDEANALLRAESEVATRMRKTQT 572

  Fly   588 ELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTL 652
            |....::..|..||::.|....|:..|..|.:||..|||.:..||..::|..|...:.:.::..:
Zfish   573 ESSKQLQQLEAHVRELQDKCCMLENSKLTLERENISLQAALDTEKREQTQGSETISDLQARITGM 637

  Fly   653 INDIERTMCREQKAQEDNRALLEKISDLEKAHAG----LDFELKAAQGRYQQEVKAHQETEKSRL 713
            .:::.:......||:.:.|.|.||::|:||..:.    :.::||..|...:||..||:.| |:||
Zfish   638 EDEVRQMRQALSKAETEKRQLQEKLTDMEKEKSNNQIDMTYKLKMLQQGLEQEEAAHKAT-KARL 701

  Fly   714 VSR-------EEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEG 771
            ..:       |.|..:.||.|:.||.||:|::.:.:....|.|::.|||..||:|...:|::|..
Zfish   702 ADKNMISESIEGAKSEAVKELEQKLQEERSSKQRVENRVLELEKKNSMLDCDYKQSLQKLEELRR 766

  Fly   772 ECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDL 836
            ...:.:|:|..|..:::||..||....::|.:.:.:::.||:.|.||::|::...|.||..|:..
Zfish   767 HKERLTEEVKNLNLKIEQEVQKRTLTQNDLKVQNQQLSTLRTSEKQLKQEINHILEIKRSLEKQN 831

  Fly   837 TQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAER-------LSKIEDLEEERVS 894
            .:|:....::....:|||.||||||.||.|||||..|.:||..|:       ...:::|:|||.|
Zfish   832 MELRKERQDSDGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKNKLYKDVQQNLQELQEERDS 896

  Fly   895 LKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAE 959
            |..|:::.:.:||||.||||||||..:||||||.:||||:|:.:.:||.|:..|:..:::|:||.
Zfish   897 LAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHRQELAEKDTTISSLEEAN 961

  Fly   960 NEL----------HKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKNEVLLKQV 1014
            ..|          .::...|..|.||.:|..|.:::.:..::.:.::::       ::|..||..
Zfish   962 RTLTSDVANLANEKEEFNNKLKEAEDYLQNLKNEEQSITQVKLALEKQL-------QSERTLKTQ 1019

  Fly  1015 AVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQ 1075
            |||||||:|||:  ::....::..:..::|:||||.|:||.||..||:|.|..::|:|    |:|
Zfish  1020 AVNKLAEIMNRK--EVRGGGSRRGNDTDVRRKEKENRKLQLELRSEREKLNSTIIKYQREINDIQ 1082

  Fly  1076 QLCAEEQQLKQKMVMEIDCKATEIENLQSKLN-------ETASLSSADNDPEDSQHSSLLSLTQD 1133
            ....:|.|::.::.|.:|.|.::||.|:|.||       ::||:||.   |:.....|||.:.  
Zfish  1083 AQLLDESQVRIELQMALDSKDSDIEQLRSLLNSLNVQSLDSASMSSG---PDMDTDESLLEIR-- 1142

  Fly  1134 SVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQ 1198
              .|||||:|.:.|.:| .||:|:||:|||:||:||||:.||.: ::..::||:.|::|||||||
Zfish  1143 --LEGWLSLPVRNNTKR-FGWERKYVVVSSKKILFYNSEQDKEH-SNPYMVLDIDKLFHVRSVTQ 1203

  Fly  1199 GDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGT----IVHKGHEFVHI 1259
            .||.||||||||||||:|||.||.|.:..|...|             ||.    |.||||||:..
Zfish  1204 TDVYRADAKEIPRIFQILYANEGESKKEQELEPL-------------PGDKSSYICHKGHEFIPT 1255

  Fly  1260 TYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVD-KHDPLAPCKLNHDPRSARDMLLLA 1323
            .||.||.||.|.||||:|||||.|.||:||..|.||:|:| |.:.:|||::  |..:|:::||||
Zfish  1256 LYHFPTNCEACTKPLWNMFKPPPALECRRCHIKCHKDHMDKKEEVIAPCRV--DMSTAKNLLLLA 1318

  Fly  1324 ATPEDQSLWVARLLKRI-QKSGYKAASYNNNSTDGSKISPSQSTR 1367
            ::.|||..||:||:|:| :|.....|.:.::.....|:..|||.|
Zfish  1319 SSQEDQQKWVSRLMKKIPKKPPAPDAPHRSSPRVPVKVQSSQSMR 1363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 243/349 (70%)
S_TKc 87..349 CDD:214567 193/261 (74%)
SbcC 484..1088 CDD:223496 203/643 (32%)
Rho_Binding 963..1027 CDD:286056 19/63 (30%)
PH_ROCK 1134..1250 CDD:269948 58/119 (49%)
C1 1254..1307 CDD:197519 31/53 (58%)
rock2aNP_777288.1 STKc_ROCK2 25..403 CDD:270771 256/377 (68%)
S_TKc 78..340 CDD:214567 193/261 (74%)
DUF4631 431..1028 CDD:292090 188/605 (31%)
HR1_ROCK2 491..557 CDD:212028 20/66 (30%)
Rho_Binding 965..1032 CDD:286056 19/75 (25%)
PH_ROCK 1141..1246 CDD:269948 58/123 (47%)
C1 1250..1304 CDD:237996 31/53 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170575975
Domainoid 1 1.000 410 1.000 Domainoid score I657
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21010
Inparanoid 1 1.050 1085 1.000 Inparanoid score I236
OMA 1 1.010 - - QHG46537
OrthoDB 1 1.010 - - D36370at33208
OrthoFinder 1 1.000 - - FOG0001986
OrthoInspector 1 1.000 - - otm24453
orthoMCL 1 0.900 - - OOG6_104177
Panther 1 1.100 - - O PTHR22988
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2768
SonicParanoid 1 1.000 - - X1475
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1615.800

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