DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Lats1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001128015.2	Gene:	Lats1 / 308265	RGDID:	1564085	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	159/510 - (31%)
Similarity:	254/510 - (49%)	Gaps:	108/510 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKY 70
            |.|.|.....:.|:::   ||.||               :...:|....:.:|::  :.|..:.|
  Rat   648 ENVLKSHQQRLHRKKQ---LENEM---------------MRVGLSQDAQDQMRKM--LCQKESNY 692

  Fly    71 KPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEE 135
                :::.:.:|:...|..||.:|.||||||.|.|...:..:||.|.|.|.:::.|...|....|
  Rat   693 ----IRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753

  Fly   136 RHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSL---MGDYDIPEKWAIFYTMEVVLAL 197
            |.|:|.|::||:|:|:::|||...||.|||::||||::||   ||.:  ||..|.||..|:..|:
  Rat   754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIF--PENLARFYIAELTCAV 816

  Fly   198 DTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC------------------------------- 231
            :::|.|||:|||:||||:|:|..||:||.|||.|
  Rat   817 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSSEWGD 881

  Fly   232 ---MRMG------------ANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYE 281
               .|.|            .:.:.::.:.||||:||:||||...|    |.:.|||||||:.|:|
  Rat   882 PSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----YTQLCDWWSVGVILFE 942

  Fly   282 MLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAH 346
            ||.|:.||.|.:.:.|..|:::.:.||..||:.::|.:|..||.........|||:.|.::||||
  Rat   943 MLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1007

  Fly   347 PFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD-----------------------EKP 388
            |||:...:|.| :|:.....:|:::...||.||:.::.|                       :.|
  Rat  1008 PFFKTIDFSSD-LRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGNEEENINDTLNGWYKNGKHP 1071

  Fly   389 EEV---FPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNN 440
            |..   |...:.||.|..|: .:....:|:.:||...:.:|.|.: .::|:..||
  Rat  1072 EHAFYEFTFRRFFDDNGYPY-NYPKPIEYEYVSSQGSEQQSDEDD-QHTGSDVNN 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	141/424 (33%)
		S_TKc	87..349	CDD:214567	120/310 (39%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Lats1	NP_001128015.2	UBA_like_SF	103..143	CDD:419673
		PHA03247	<183..590	CDD:223021
		STKc_LATS1	703..1084	CDD:270775	134/387 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920