DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Lats2

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_001100737.1	Gene:	Lats2 / 305922	RGDID:	1305906	Length:	1042	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	165/504 - (32%)
Similarity:	244/504 - (48%)	Gaps:	111/504 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKY 70
            |.|.|.....|.||.:   ||:||               ..|.:.:.:.|.:|::  :.|..:.|
  Rat   569 ENVIKTYQQKVSRRLQ---LEQEM---------------AKAGLCETEQEQMRKI--LYQKESNY 613

  Fly    71 KPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEE 135
            .    ::.:.:|:...|..||.:|.||||||.|.....:..:||||.|.|.:::.|...|....|
  Rat   614 N----RLKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAE 674

  Fly   136 RHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDI-PEKWAIFYTMEVVLALDT 199
            |.|:|.|::||:|:|:::|||...||.|||::||||::||:...:: ||..|.||..|:.||:::
  Rat   675 RDILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIES 739

  Fly   200 IHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC--------------------------------- 231
            :|.|||:|||:||||:|:|..||:||.|||.|
  Rat   740 VHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGNHIRQDSMEPGDLWDDVS 804

  Fly   232 -MRMGANGQVVSSNA------------VGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEML 283
             .|.|...:.:...|            ||||:||:||||..:|    |.:.|||||||:.|:|||
  Rat   805 NCRCGDRLKTLEQRAQKQHQRCLAHSLVGTPNYIAPEVLLRKG----YTQLCDWWSVGVILFEML 865

  Fly   284 FGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPF 348
            .|:.||.|.:...|..|:::.:|:|..|.:|::|.:|:.||.........||||.|.:|:|||||
  Rat   866 VGQPPFLAPTPTETQLKVINWENTLHIPTQVKLSAEARDLITKLCCAADCRLGRDGADDLKAHPF 930

  Fly   349 FRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD----------------------EKPEEV 391
            |....:|.| ||:...|.||.:|...||.||:.::.:                      :.||..
  Rat   931 FSTIDFSRD-IRKQPAPYVPTISHPMDTSNFDPVDEESPWHEASGESAKAWDTLASPNSKHPEHA 994

  Fly   392 ---FPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAA 437
               |...:.||.|..||          .....:..|||.:...|..|.|
  Rat   995 FYEFTFRRFFDDNGYPF----------RCPKPSEPAESADPGDAELGGA 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	146/421 (35%)
		S_TKc	87..349	CDD:214567	121/308 (39%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Lats2	NP_001100737.1	UBA_LATS2	101..141	CDD:270581
		PHA03247	<143..490	CDD:223021
		PKc_like	624..1004	CDD:419665	138/384 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920