Protein Alignment Rok and Rock2

DIOPT Version :9

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: XP_008762796.1
• Gene: Rock2 / 25537
• RGDID: 3590
• Length: 1473
• Species: Rattus norvegicus
• Alignment Length: 1468
• Identity: 631/1468 - (42%)
• Similarity: 878/1468 - (59%)
• Gaps: 157/1468 - (10%)

  Fly    21 RANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVE 85
            |...||..:|||.|..||:.|||.:::||.|.|..:||:.|||:.:..:|:.:..:|..|:|..|
  Rat    26 RQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAE 90

  Fly    86 DFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQL 150
            |:..:|:||.||||||||||||:|.:|||||.||||||:||.|||||||||.|||.|||.|:|||
  Rat    91 DYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQL 155

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNM 215
            ..||||.:||||||::|||||:|:||.:||:|||||.|||.|||||||.||:||.:|||||||||
  Rat   156 FCAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNM 220

  Fly   216 LLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLY 280
            |||.:||||||||||||:|...|.|....|||||||||||||:|||.|..|||||||||||:||:
  Rat   221 LLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLF 285

  Fly   281 EMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKA 345
            |||.|:||||||||||||.|||||||||.||.:.|||:.||.||.||||||..||||.|:|:||.
  Rat   286 EMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQ 350

  Fly   346 HPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTY 410
            ||||:||.|::|||||:..|||||||||.|:.||:|||.|:...|.||:||.|.||.||||||||
  Rat   351 HPFFKNDQWNWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTY 415

  Fly   411 TGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNEL-KRLEALLERERGRSEAL 474
            ..: .||.||:......:|                ....:...|.|: |:|.||.|......:|.
  Rat   416 FRE-NLLLSDSPPCRENDA----------------IQTRKSEESQEIQKKLYALEEHLSSEVQAK 463

  Fly   475 EQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQE--------IELRKKT- 530
            |:    |.|:.:.|..|   |::.|.|.|:::..|: |.:..::::|:|        .|.::|.
  Rat   464 EE----LEQKCKSINTR---LEKTAKELEEEITFRK-NVESTLRQLEREKALLQHKNAEYQRKAD 520

  Fly   531 -EALLVETQRNLENE---QKTRARDLN--------INDKVVSLEKQLLEMEQSYKTETENTQKLK 583
             ||   :.:|||||:   .|.:..||.        ..:||..|:|||.|.....:||::...:|:
  Rat   521 HEA---DKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRTESDTAARLR 582

  Fly   584 KHNAELDFTVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENK 648
            |..||....::..|...||:.|....|:..|.:|.:|...||:.:..|:..|:...|:..:.:.:
  Rat   583 KTQAESSKQIQQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGR 647

  Fly   649 MQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLD----FELKAAQGRYQQEVKAHQETE 709
            :..|..|::.......|.:.:.|.|.||::||||..:.::    ::||..|...:|| :|..:|.
  Rat   648 ISGLEEDLKTGKTLLAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQLKVIQQSLEQE-EAEHKTT 711

  Fly   710 KSRLVSR-------EEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQ 767
            |:||..:       |||..:.:|.::.||.||:|.:.|.:....|.|::.|:|..|.:|.|.:|.
  Rat   712 KARLADKNKIYESIEEAKSEAMKEMEKKLLEERSLKQKVENLLLEAEKRCSILDCDLKQSQQKLN 776

  Fly   768 KLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRF 832
            :|..:....:|.|..|..:::||..||..:.::|.:.:.:|..|:..|.|:::|.:...|.|...
  Rat   777 ELLKQKDVLNEDVRNLTLKIEQETQKRCLMQNDLKMQTQQVNTLKMSEKQIKQENNHLMEMKMNL 841

  Fly   833 EEDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERL-------SKIEDLEE 890
            |:...:|:....:|....:|||.||||||.||.|||||..|.:||:.|:.       .|.:||::
  Rat   842 EKQNAELRKERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQD 906

  Fly   891 ERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATL 955
            ||.||..|:::.:.:||||.||||||||..:||||||.:||||:|:.:.:|:.|:..|:|.:|:|
  Rat   907 ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASL 971

  Fly   956 KEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCK------NEVLLKQV 1014
            :|....|...:...|.|.|:|..:.|..||:|:.:   |||||:....|.:      .|..||..
  Rat   972 EETNRTLTSDVANLANEKEELNNKLKDTQEQLSKL---KDEEISAAAIKAQFEKQLLTERTLKTQ 1033

  Fly  1015 AVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQ 1075
            |||||||:|||      |:..|..|..::|:||||.|:|..||..||:|..|.::|:|    ::|
  Rat  1034 AVNKLAEIMNR------KEPVKRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQ 1092

  Fly  1076 QLCAEEQQLKQKMVMEIDCKATEIENLQSKLN------ETASLSSADNDPE-------------- 1120
            ...|||.|::.::.|.:|.|.::||.|:|:|.      :::|:.|...|.|
  Rat  1093 AQIAEESQIRIELQMTLDSKDSDIEQLRSQLQALHIGMDSSSIGSGPGDAEPDDGFPVHITQSHT 1157

  Fly  1121 ------------------------------DSQHSSLLSL-------TQDSVFEGWLSVPNKQNR 1148
                                          ||:..||..|       :.:|..|||||:|.:.|.
  Rat  1158 MESMSFTYQRSSTSLNIATKPSSSHMLLDSDSEEDSLPYLPSSSEPISTESRLEGWLSLPVRNNT 1222

  Fly  1149 RRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIF 1213
            :: .||.::||||||:||:||:|:.||.. ::..::||:.|::|||.|||.||.|||||||||||
  Rat  1223 KK-FGWVKKYVIVSSKKILFYDSEQDKEQ-SNPYMVLDIDKLFHVRPVTQTDVYRADAKEIPRIF 1285

  Fly  1214 QLLYAGEGASHRPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMF 1278
            |:|||.||.|.:..|.....|.        |:...|.||||||:...||.||.||.|.|||||||
  Rat  1286 QILYANEGESKKEPEFPVEPVG--------EKSNYICHKGHEFIPTLYHFPTNCEACMKPLWHMF 1342

  Fly  1279 KPPAAYECKRCRNKIHKEHVDKHDP-LAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQK 1342
            |||.|.||:||..|.||:|:||.:. :||||:.:|..||:::||||.:.|:|..||:||:|:|.|
  Rat  1343 KPPPALECRRCHIKCHKDHMDKKEEIIAPCKVYYDISSAKNLLLLANSTEEQQKWVSRLVKKIPK 1407

  Fly  1343 SGYKAASYNNNSTDGS-KISPSQSTRSSYKPYAVNVQR 1379
            .......:..:|...| ||..:||.|...:..|.|..|
  Rat  1408 KPPAPDPFARSSPRTSMKIQQNQSIRRPSRQLAPNKPR 1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	244/349 (70%)
		S_TKc	87..349	CDD:214567	194/261 (74%)
		SbcC	484..1088	CDD:223496	215/652 (33%)
		Rho_Binding	963..1027	CDD:286056	27/69 (39%)
		PH_ROCK	1134..1250	CDD:269948	55/115 (48%)
		C1	1254..1307	CDD:197519	32/53 (60%)
Rock2	XP_008762796.1	STKc_ROCK2	39..417	CDD:270771	257/377 (68%)
		S_TKc	92..354	CDD:214567	194/261 (74%)
		Smc	<437..1101	CDD:224117	225/684 (33%)
		HR1_ROCK2	505..571	CDD:212028	19/68 (28%)
		Rho_Binding	979..1046	CDD:286056	27/75 (36%)
		PH_ROCK	1208..1314	CDD:269948	55/115 (48%)
		C1	1318..1364	CDD:237996	29/45 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336832
Domainoid	1	1.000	412	1.000	Domainoid score	I658
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21010
Inparanoid	1	1.050	1074	1.000	Inparanoid score	I232
OMA	1	1.010	-	-		QHG46537
OrthoDB	1	1.010	-	-		D36370at33208
OrthoFinder	1	1.000	-	-		FOG0001986
OrthoInspector	1	1.000	-	-		otm46140
orthoMCL	1	0.900	-	-		OOG6_104177
Panther	1	1.100	-	-	O	PTHR22988
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1475
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910