DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rok and Cdc42bpg

DIOPT Version :9

Sequence 1:NP_536796.2 Gene:Rok / 43916 FlyBaseID:FBgn0026181 Length:1390 Species:Drosophila melanogaster
Sequence 2:NP_001028514.1 Gene:Cdc42bpg / 240505 MGIID:2652845 Length:1551 Species:Mus musculus


Alignment Length:1463 Identity:389/1463 - (26%)
Similarity:608/1463 - (41%) Gaps:451/1463 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 VERRRRANTLEREMR-DPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQ 79
            :|:|.||  ||:.:| :......:|.|||.:..:..:.....|||.:|:.|:.:...|...::.:
Mouse     1 MEQRLRA--LEQLVRGEAGGSPGLDGLLDLLLGVHQELSSAPLRRERNVAQFLSWASPFVTKVKE 63

  Fly    80 LRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANS 144
            ||:..:||..:|:||.||||||.:||.:.|.|::|||.|.|:||:||.::|.|.|||.::...:|
Mouse    64 LRLQRDDFEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDS 128

  Fly   145 EWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVH 207
            .|:..||:||||.:|||:|||:..|||:::|:..::  :|.:.|.||..|:|||:.::|.:|:||
Mouse   129 RWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVH 193

  Fly   208 RDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS--QGVDNEYGREC 270
            |||||||:|||..||::|||||:|:|:..||.|.||.|||||||||||:||:  :| ...||.:|
Mouse   194 RDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEG-KGHYGPQC 257

  Fly   271 DWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQR 334
            ||||:|:..||:|||||||||:|||.||||||:|::.|.||.:| ::...|:.|||..|..:.:|
Mouse   258 DWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEER 322

  Fly   335 LGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD--EKPEEVFPVPKG 397
            |||.|::|.:.||||....|  :.:..|..|.:|||....||.|| |::.|  .:||.:.|...|
Mouse   323 LGRGGLDDFRKHPFFEGVDW--ERLATSTAPYIPELRGPMDTSNF-DVDDDTLNRPETLPPSSHG 384

  Fly   398 -FDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLE 461
             |.|:||||:|||||      |....|.:|.|                                 
Mouse   385 AFSGHHLPFVGFTYT------SGSPFDVQSSE--------------------------------- 410

  Fly   462 ALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIEL 526
             |:....|....:||      .::||..|.:..|.......|             :.::::|:::
Mouse   411 -LMAAPEGTPHCVEQ------VKVELSHKCQEPLHGPLQPQE-------------LVRLQKEVQV 455

  Fly   527 RKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDF 591
                                              |:::|.|..:..|.....|..|.        
Mouse   456 ----------------------------------LQEKLAETLRDSKASLSQTDGLH-------- 478

  Fly   592 TVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDI 656
             .:|....::        ||:.|:.|.||..|.||.      ||.|      :||          
Mouse   479 -ARSPAPNIQ--------LQQEKDRLQQELTEAQAA------LRVQ------DAE---------- 512

  Fly   657 ERTMCREQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANL 721
               :|:.|..||:                            :.|.:...||        ||.|..
Mouse   513 ---LCQAQNRQEE----------------------------FLQRLWEAQE--------REAAAA 538

  Fly   722 QEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQ 786
            .:::||.|:|.|....|       :|.|.|::.||.:       :.:|:|:|:|||       ||
Mouse   539 SQIQALNSQLEEAWVVR-------RELEGQVTTLSQE-------VTRLQGQCKQES-------SQ 582

  Fly   787 LDQEHS--KRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKR----------------RFE 833
            ....|:  :.|.:.|...         :|:|.||:||::..||...                |.:
Mouse   583 AKTVHAAPETNGIGSPEG---------QSQEAQLRKEVAALREQLEHACSQGISVGKEEVLCRLQ 638

  Fly   834 EDLTQLKSTHHEALANNRELQAQLEAEQCFSRLYKTQANENREESAERLSKIEDL----EEERVS 894
            |: .|..|...|.||.  ||:.:|:::|   ||    ..|.||..:...::|.|:    .:|:||
Mouse   639 EE-NQRLSREQERLAG--ELELELQSKQ---RL----EGERRETESNWEAQIADILSWVNDEKVS 693

  Fly   895 LKHQVQVAVARADSEALARSIAEETVAD-----------LEKEKTIKELELKDFVMKHRNEINAK 948
            ..:...:|...|:.....|::..:|:..           |:|.:....|||:..:   ..||.||
Mouse   694 RGYLQALATKMAEELESLRNVGTQTLPTRPLDHQWKARRLQKMEASARLELQSAL---EAEIRAK 755

  Fly   949 EA---ALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLL-------- 1002
            ::   .|..::||:.:..::|.:...:.:.|.|:..:.:|||...........|.|:        
Mouse   756 QSLQEQLTQVQEAQRQAERRLQEAEKQSQALQQEVAELREELQARGPGDARPSTSLIPLLSFWNT 820

  Fly  1003 --DKCKN------------EVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRL 1053
              |..|:            |..|:......|     |..|..|:......:.||....:.....|
Mouse   821 EKDSAKDPGNSGEGPRSGAEAELRPEGRRSL-----RMGSVFPRVPAATTTPAEGPPAKPGSHTL 880

  Fly  1054 QQELSQERDKFNQ-----LLLKHQDL---------QQLCAEEQQLKQKMVMEIDCKATEIENLQS 1104
            :........|..:     |.|..|.|         ...||.:..         .|.... |.|::
Mouse   881 RPRSFPSPTKCLRCTSLMLGLGRQGLGCDTCGYFCHSACASQAP---------PCPVPP-ELLRT 935

  Fly  1105 KLN---ETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKI 1166
            .|.   ||.:                     .:.:||:||||.....||  ||:|.|..:|..::
Mouse   936 ALGVHPETGT---------------------GTAYEGFLSVPRPSGVRR--GWQRVYAALSDSRL 977

  Fly  1167 IFYNSDIDKHNTTDAVLI--LDL-SKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDE 1228
            :.:::...:.:....||:  ||| ...:....|...|||.|.:|::||||::            .
Mouse   978 LLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRV------------T 1030

  Fly  1229 QSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVC----------------------- 1270
            .|||.|.                            ||.|.|.                       
Mouse  1031 ASQLTVP----------------------------PTTCTVLLLAENEGERERWLQVLGELQRLL 1067

  Fly  1271 ------PKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAP---CKLNHDPRSARDMLLLAATP 1326
                  |:|::.:                 ||..|...||.|   |....|    ::.|.|..  
Mouse  1068 LDARPRPRPVYTL-----------------KEAYDNGLPLLPHALCAAVID----QERLALGT-- 1109

  Fly  1327 EDQSLWVARL----------LKRIQKSGYKAAS 1349
             ::.|:|..|          .:|:|:....:|:
Mouse  1110 -EEGLFVIHLHSNDIFQVGDCRRVQRLAVSSAA 1141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RokNP_536796.2 STKc_ROCK 61..411 CDD:270747 175/357 (49%)
S_TKc 87..349 CDD:214567 142/266 (53%)
SbcC 484..1088 CDD:223496 130/675 (19%)
Rho_Binding 963..1027 CDD:286056 14/85 (16%)
PH_ROCK 1134..1250 CDD:269948 32/118 (27%)
C1 1254..1307 CDD:197519 12/84 (14%)
Cdc42bpgNP_001028514.1 STKc_DMPK_like 69..399 CDD:270748 170/333 (51%)
S_TKc 71..337 CDD:214567 142/266 (53%)
Taxilin 452..774 CDD:286771 99/476 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 578..605 9/42 (21%)
DMPK_coil 743..798 CDD:117396 14/57 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 820..886 11/70 (16%)
C1_1 878..926 CDD:278556 8/56 (14%)
PH_MRCK 937..1069 CDD:269949 39/194 (20%)
CNH 1096..1359 CDD:279162 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1551
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0612
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D759391at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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