DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Cdc42bpb

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006515826.1	Gene:	Cdc42bpb / 217866	MGIID:	2136459	Length:	1730	Species:	Mus musculus

Alignment Length:	1355	Identity:	385/1355 - (28%)
Similarity:	655/1355 - (48%)	Gaps:	230/1355 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RANTLEREMRD----PTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLR 81
            |...||:.:.|    ..|..:|:.|||.:..|.::|.|.:|||.|.:.::....||....:..::
Mouse     6 RLKKLEQLLLDGPWRNDSALSVETLLDVLVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKDMQ 70

  Fly    82 MNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEW 146
            ::.|||..||:||.||||||.:|:.|::.::||||.|:|:||:||.::|.|.|||.::.:.:.:|
Mouse    71 LHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW 135

  Fly   147 IVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRD 209
            |..||:||||..|||:|||:..|||:::|:..::  :||..|.||..|:|||:|:||.:.:||||
Mouse   136 ITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRD 200

  Fly   210 VKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS--QGVDNEYGRECDW 272
            :||||:|||..||::|||||:|::|..:|.|.||.|||||||||||:||:  .|: .:||.||||
Mouse   201 IKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM-GKYGPECDW 264

  Fly   273 WSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLG 336
            ||:|:.:||||:|||||||:|||.||||||:|:....||..| ::||:||.||:..:..|.:|||
Mouse   265 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLICSRERRLG 329

  Fly   337 RYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDE-KPEEVFPVPK--GF 398
            :.||||.|.|.||....|  :|||....|.:|::||..||.|| |::.|. :..|:.|...  ||
Mouse   330 QNGIEDFKKHAFFEGLNW--ENIRNLEAPYIPDVSSPSDTSNF-DVDDDMLRNIEILPPGSHTGF 391

  Fly   399 DGNHLPFIGFTYTGDYQLLSSDTVDAES--KEANVANSGAASNNHGHGHNHRHRPSNSNELKRLE 461
            .|.||||||||:|            .||  .:.....|...||......:.:....||.:::..|
Mouse   392 SGLHLPFIGFTFT------------TESCFSDRGSLKSMTQSNTLTKDEDVQRDLENSLQIEAYE 444

  Fly   462 ALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIEL 526
            ..:.|       |||      :::||..|.:...|.:.|.:....||...|....::::.:|:|.
Mouse   445 RRIRR-------LEQ------EKLELSRKLQESTQTVQSLHGSTRALGNSNRDKEIKRLNEELER 496

  Fly   527 RKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDF 591
            .|...|.....:|.||:....|....:...::..||||       |:...:..::|.|...|...
Mouse   497 MKSKMADSNRLERQLEDTVTLRQEHEDSTHRLKGLEKQ-------YRLARQEKEELHKQLVEASE 554

  Fly   592 TVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDI 656
            .:|||.::::|.........:...||.:..:||::|   ::.:..||::..:|.|..||. |:.:
Mouse   555 RLKSQTKELKDAHQQRKRALQEFSELNERMSELRSL---KQKVSRQLRDKEEEMEVAMQK-IDSM 615

  Fly   657 ERTMCREQKAQEDNRALLE----------KISDLEKAHA-GLDFELKA-----------AQGRYQ 699
            .:.:.:.:|::::..|.||          |:.:..::.. .::.||:|           |...:|
Mouse   616 RQDLRKSEKSRKELEARLEDAAAEASKERKLREHSESFCKQMERELEALKVKQGGRGPGAASEHQ 680

  Fly   700 QEV-KAHQETEK------SRLVSREEANLQEVKALQSKLNEEKSARI----------------KA 741
            ||: |...|.||      ..||.||.:::.|||.::.::::.:|.::                |.
Mouse   681 QEISKIRSELEKKVLFYEEELVRREASHVLEVKNVKKEVHDSESHQLALQKEVLMLKDKLEKSKR 745

  Fly   742 DQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSELSLHSS 806
            ::|| |.|..:..:...|.:.:..|.....:...|:||:.:...:|..::.:....|.:|:....
Mouse   746 ERHS-EMEEAIGTVKDKYERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLASKKE 809

  Fly   807 EVAHLRSRENQLQKELSTQREAK-------RRFEEDLTQLKSTHHEALANNRELQAQLEAEQCFS 864
            .|||..::..::.:.:|.:::|:       .:..|:|..|:|:.    ..:|.|..
Mouse   810 SVAHWEAQIAEIIQWVSDEKDARGYLQALASKMTEELETLRSSS----LGSRTLDP--------- 861

  Fly   865 RLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTI 929
             |:|.:.::..:.|| ||               ::|.|:   ::|..|:.:.:|.:..::.....
Mouse   862 -LWKVRRSQKLDMSA-RL---------------ELQSAL---EAEIRAKQLVQEELRKVKDSSLA 906

  Fly   930 KELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQH---KKQQEELALMR 991
            .|.:||:...|:|..:   |...:..|..|.:.....|.|..:::|.:.::   .....:|....
Mouse   907 FESKLKESEAKNRELL---EEMQSLRKRMEEKFRADTGLKLPDFQDSIFEYFNTAPLAHDLTFRD 968

  Fly   992 SSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQE 1056
            |......:.||      .|.:..:.....|....: .||....:.|.||    :::::|.|.||.
Mouse   969 SLSSSSASSLL------ALWEDTSSASDQETQASK-MDLSPSVSVATST----EQQEDMARPQQR 1022

  Fly  1057 -------------LSQERDKFNQLLLKHQDLQQLCAEEQQLKQKMVME------------IDCKA 1096
                         ::..:.|.:|..:|.......|:....|...::.:            :.||
Mouse  1023 PSPVPLPSTQALAMAGPKPKAHQFSIKSFPSPTQCSHCTSLMVGLIRQGYACEVCAFSCHVSCK- 1086

  Fly  1097 TEIENLQSKLNETASLSSADN----DPEDSQHSSLLSLTQ--DSVFEGWLSVPNKQNRRRGHGWK 1155
                            .||..    .||.|:....:.:.:  .:.::|::.||.....::  ||:
Mouse  1087 ----------------DSAPQVCPIPPEQSKRPLGVDVQRGIGTAYKGYVKVPKPTGVKK--GWQ 1133

  Fly  1156 RQYVIVSSRKIIFYNSDIDKHNTTD----AVLILDL-SKVYHVRSVTQGDVIRADAKEIPRIFQL 1215
            |.|.:|...|:..|  |:.:..:|.    |..:||| .:.:.|.||...|||.|..::||.||::
Mouse  1134 RAYAVVCDCKLFLY--DLPEGKSTQPGVVASQVLDLRDEEFAVSSVLASDVIHATRRDIPCIFRV 1196

  Fly  1216 LYAGEGASHRPDEQSQLDVSVLHGNCNEERP--------GTIVHKGH---EFVHI 1259
            ..:..|:   |.:.|.|  .:|..|.||:|.        ..|:||..   :.||:
Mouse  1197 TASLLGS---PSKTSSL--LILTENENEKRKWVGILEGLQAILHKNRLKSQVVHV 1246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	179/357 (50%)
		S_TKc	87..349	CDD:214567	145/266 (55%)
		SbcC	484..1088	CDD:223496	130/671 (19%)
		Rho_Binding	963..1027	CDD:286056	9/66 (14%)
		PH_ROCK	1134..1250	CDD:269948	36/128 (28%)
		C1	1254..1307	CDD:197519	2/9 (22%)
Cdc42bpb	XP_006515826.1	STKc_MRCK_beta	3..411	CDD:270774	197/420 (47%)
		SbcC	429..>933	CDD:223496	113/564 (20%)
		KELK	527..606	CDD:374120	20/88 (23%)
		C1	1044..1093	CDD:237996	8/65 (12%)
		PH_MRCK	1103..1237	CDD:269949	38/142 (27%)
		CNH	1263..1529	CDD:366300
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820