Protein Alignment Rok and mrck-1

DIOPT Version :10

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_504599.2
• Gene: mrck-1 / 179013
• WormBaseID: WBGene00006437
• Length: 1592
• Species: Caenorhabditis elegans
• Alignment Length: 1295
• Identity: 363/1295 - (28%)
• Similarity: 611/1295 - (47%)
• Gaps: 295/1295 - (22%)

  Fly    21 RANTLEREMRDPTS----ICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLR 81
            |..|||....|..|    ..:.:.|:|::..|..:|.:.:||:.|.|.::....|.:..:..:||
 Worm    13 RLKTLENIYMDGPSKKPEALSFETLIDSLICLYDECCNSTLRKEKCIAEFVESVKTVISKAKKLR 77

  Fly    82 MNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEW 146
            ::.:||..:|:||.||||||.:||.:...::||||.|:|:||:||.::|.|.|||.::.:.:..|
 Worm    78 LSRDDFEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRW 142

  Fly   147 IVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY--DIPEKWAIFYTMEVVLALDTIHNMGFVHRD 209
            |..||:||||.|.||.|||:..|||:::|:..:  .|||..|.||..|:|||:|::|.:|:||||
 Worm   143 ITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRD 207

  Fly   210 VKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS-QGVDNEYGRECDWW 273
            |||||:|||..||::|||||:|:|:.|:|.|.|:.|||||||||||:|:: :.....||:|||||
 Worm   208 VKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGRGRYGKECDWW 272

  Fly   274 SVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFP-PEVE--ISEQAKALIRAFLTDRTQRL 335
            |:||.:||||:|.||||::.||.||||||.|::.|.|| .|::  :||:||.|||..:.....|.
 Worm   273 SLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEIDWVVSEEAKDLIRQLICSSDVRF 337

  Fly   336 GRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFE-DI-ERDEKP--EEVFP--V 394
            ||.|:.|.:.||||....|  :.||:|.||.|||:||.:||.||: |: |.|..|  :|..|  |
 Worm   338 GRNGLSDFQLHPFFEGIDW--NTIRDSNPPYVPEVSSPEDTSNFDVDVCEDDFTPCLQETQPPRV 400

  Fly   395 PKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKR 459
            ...|.||||||:||:||                               ||.......|.::|::
 Worm   401 LAAFTGNHLPFVGFSYT-------------------------------HGSLLSDARSLTDEIR- 433

  Fly   460 LEALLERERGRSEALEQQDAGL-----RQQIELITKREAELQRIASEY--EKDLALRQHNYKVAM 517
              |:.:|.:|.:|.:|:...|.     .::.||:.|.: |.|.|.:::  |...:....||:..:
 Worm   434 --AIAQRCQGDAELMEKSVDGFMVELENEKAELVQKLK-EAQTIIAQHVAENPRSEEDRNYESTI 495

  Fly   518 QKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKL 582
            .:::.||::..|.    :|.:...:.:||.:       |::|:      |.|:..|...|..::|
 Worm   496 AQLKDEIQILNKR----LEDEALAQQQQKPK-------DEIVA------ESEKKLKELKERNKQL 543

  Fly   583 KKHNAELDFTVKSQEEKVRDMVDMI----DTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHK 643
            ....:|    ::.:.:.:.|.:|.:    .|:.:.::::..|.|::...::.||:   .:|.:..
 Worm   544 VMEKSE----IQRELDNINDHLDQVLVEKATVVQQRDDMQAELADVGDSLLTEKD---SVKRLQD 601

  Fly   644 EAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLE-KAHAGLDFELKAAQGRYQQEVKAHQE 707
            ||| |.:..:.|.|..:   ::.:.:..||::|..::. :|...::     ......:||.|.:.
 Worm   602 EAE-KAKKQVADFEEKL---KEIETEKIALIKKQEEVTIEARKSVE-----TDDHLSEEVVAAKN 657

  Fly   708 TEKSRLVSREEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGE 772
            |..|...:.||.. .|:|.|:.:::||:::      |:.:.|:::..|...|.    |.||:
 Worm   658 TIASLQATNEERE-TEIKKLKQRMDEERAS------HTAQSEQEMKQLEAHYE----RAQKM--- 708

  Fly   773 CRQESEKVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRS---RENQLQKELS--TQREAKRRF 832
                      ||..::|.:.:...|..|:...|.::|.|..   .|.||.:..:  ::.:|.|..
 Worm   709 ----------LQDNVEQMNVENRGLRDEIEKLSQQMAALPRGGLNEQQLHEIFNWVSEEKATREE 763

  Fly   833 EEDLTQLKSTHHEALANNR-----------------------------ELQAQLEAEQCFSRLYK 868
            .|:||:..:...|:|.||.                             :||.||:||.......|
 Worm   764 MENLTRKITGEVESLKNNSPLTTSNYIQNTPSGWGSRRMNNVARKDGLDLQRQLQAEIDAKLKLK 828

  Fly   869 TQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIKELE 933
            .:...::|:.....::::|.|:...||..:                     ||.|:::|.|:
 Worm   829 AELKNSQEQYLTSAARLDDTEKRMASLMRE---------------------VAMLKQQKNIE--- 869

  Fly   934 LKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKDEEI 998
                        |:.::|.::.. ...:|...:..   :||  :......::|:...:|:...|
 Worm   870 ------------NSSDSAFSSTM-GRGDLMISMNN---DYE--MSNSSLMRQEMISRQSTPSYE- 915

  Fly   999 TKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELS----- 1058
                    |.:||              .|..:||:.:      :||.|:|.|:......|
 Worm   916 --------NAILL--------------HDHQVPKRVD------DLRYKQKPMKTASGIFSPVSIS 952

  Fly  1059 -QER-DKFNQLLLKHQ-------------DLQQL------------CAEEQQLKQKMVMEIDCKA 1096
             .|| ..|.::.:|..             |.|.|            |||.        :...|..
 Worm   953 AMERGHNFERMKIKTPTKCGHCTSILIGLDRQGLFCQSCQYACHVSCAER--------VSQSCPV 1009

  Fly  1097 TEIENLQSKLNETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIV 1161
            .|.|.....::.|..:.:|                    :||.:..|.....|:  ||:..||:|
 Worm  1010 PEEERRPLGIDPTRGVGTA--------------------YEGLVKTPRAGGVRK--GWQTAYVVV 1052

  Fly  1162 SSRKIIFYNSDIDKHNTTDAV-----LILDL-SKVYHVRSVTQGDVIRADAKEIPRIFQL 1215
            ...|:..|:..:|:.|....|     |:||: ...:.|..|::.|||.|...:||:||::
 Worm  1053 CDFKLYLYDCTVDRQNKMQDVKNEIRLVLDMRDPDFTVCGVSEADVIHAQKGDIPKIFRV 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	180/361 (50%)
		Smc	527..>1121	CDD:440809	121/664 (18%)
		ROCK_SBD	849..920	CDD:409019	14/99 (14%)
		PH_ROCK	1134..1250	CDD:269948	27/88 (31%)
		C1_ROCK	1247..1310	CDD:410363
mrck-1	NP_504599.2	STKc_DMPK_like	81..417	CDD:270748	175/337 (52%)
		SMC_prok_B	454..>758	CDD:274008	71/361 (20%)
		C1_MRCK	958..1010	CDD:410359	9/59 (15%)
		PH_MRCK	1016..1159	CDD:269949	29/119 (24%)
		CNH	1182..1494	CDD:214481
		PBD	1544..1582	CDD:197628