Protein Alignment Rok and DMPK

DIOPT Version :9

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_001275693.1
• Gene: DMPK / 1760
• HGNCID: 2933
• Length: 655
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 190/511 - (37%)
• Similarity: 294/511 - (57%)
• Gaps: 44/511 - (8%)

  Fly    68 AKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFF 132
            ::.:|:.:::.::|:..:||..:|:||.|||.||.:|:.|.:.||||||.::|::|:||.:.:.|
Human    78 SRAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCF 142

  Fly   133 WEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVL 195
            .|||.::.:.:..||.||||||||..|||:||::..|||:::|:..:.  ||.:.|.||..|:|:
Human   143 REERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVM 207

  Fly   196 ALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQ 260
            |:|::|.:|:||||:||||:|||..||::|||||:|:::.|:|.|.|..|||||||:|||:||:.
Human   208 AIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAV 272

  Fly   261 G---VDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVE-ISEQAK 321
            |   ....||.|||||::|:|.|||.:|:|||||||...|||||:.:|..||.|...| :.|:|:
Human   273 GGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEAR 337

  Fly   322 ALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIER-- 384
            ..|:..|.....||||.|..|.:.||||....|  |.:|:||||..|:.....||.||:.:|.
Human   338 DFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDW--DGLRDSVPPFTPDFEGATDTCNFDLVEDGL 400

  Fly   385 ----DEKPEEVFPVPKGFD-GNHLPFIGFTYT----GDYQLLSSDTVDAESKEANVANSGAASNN 440
                ....|.:..:.:|.. |.||||:|::|:    .|.::.....::.|:::....:..|.|
Human   401 TAMVSGGGETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEAEQLLEPHVQAPS-- 463

  Fly   441 HGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQDAGLRQQIELITKREAELQRIASEYEKD 505
                    ..||.|.:.:..|..:......:||  :.:..||:..|.:.:.....|.::.|.|
Human   464 --------LEPSVSPQDETAEVAVPAAVPAAEA--EAEVTLRELQEALEEEVLTRQSLSREME-- 516

  Fly   506 LALRQHNYKVAMQKVEQEI----------ELRKKTEALLVETQRNLENEQKTRARD 551
             |:|..|...|.|..|.|.          :|:::.|.|..|....:......||.|
Human   517 -AIRTDNQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATD 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	159/355 (45%)
		S_TKc	87..349	CDD:214567	133/267 (50%)
		SbcC	484..1088	CDD:223496	18/78 (23%)
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
DMPK	NP_001275693.1	STKc_DMPK_like	95..432	CDD:270748	157/338 (46%)
		S_TKc	97..365	CDD:214567	133/267 (50%)
		DMPK_coil	496..556	CDD:117396	14/62 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920