Protein Alignment Rok and let-502

DIOPT Version :10

• Sequence 1: NP_536796.2
• Gene: Rok / 43916
• FlyBaseID: FBgn0026181
• Length: 1390
• Species: Drosophila melanogaster
• Sequence 2: NP_491440.1
• Gene: let-502 / 172088
• WormBaseID: WBGene00002694
• Length: 1173
• Species: Caenorhabditis elegans
• Alignment Length: 1380
• Identity: 445/1380 - (32%)
• Similarity: 693/1380 - (50%)
• Gaps: 250/1380 - (18%)

  Fly    25 LEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHF 89
            |..::.||.|..|::.||||::|||:||....|.|:|:::.:.::|:.:...:..|||...||..
 Worm     6 LRDQLVDPKSPINIESLLDTITALVNDCKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQ 70

  Fly    90 IKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAF 154
            :|:||.||||||.||||..::.|||||.|:|.:|:||.|||||||||.|||||||||||:|.:||
 Worm    71 LKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAF 135

  Fly   155 QDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDS 219
            ||.::|||||::|||||:|:||..|::.|||..|||.|:|.||..:|:||::||||||||||:..
 Worm   136 QDPRHLYMVMEYMPGGDLVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISI 200

  Fly   220 YGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLF 284
            .||:||||||||::|.|||.|..|.|||||||||||||::||.|.|:|:|.||||||:|:||||.
 Worm   201 SGHIKLADFGTCVKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLV 265

  Fly   285 GETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFF 349
            |||||||::||.||..||:||.||.||.|..||.|||.:|:.||:....||||..::||:.|.||
 Worm   266 GETPFYAEALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFF 330

  Fly   350 RNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIE-RDEKPEEVFPVPKGFDGNHLPFIGFTYTGD 413
            .||.|:|..:||:.|||:|.|.|||||.:||:|| ||......|.:||.|:||.||||||||:.:
 Worm   331 VNDEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTYSNE 395

  Fly   414 YQLLSSDTVDAESKEANVANS-GAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALEQQ 477
            |           |...|:... ||.|..:|   ..:|:|         :.::|:......|
 Worm   396 Y-----------SPVKNLLKGHGAGSKQNG---IEQHKP---------QTVVEQPLTNGHA---- 433

  Fly   478 DAGLRQQIELITKREAELQRIASEYEKDLALRQHNYKVAMQKVEQEIELRKKTEALLVETQRNLE 542
             :|:.::.....|.|.:.:....|..||...|.              |:|.|    ::|.::|
 Worm   434 -SGVPEEKYEAVKMELDSKNREFELLKDSIARN--------------EIRAK----MIENEKN-- 477

  Fly   543 NEQKTRARDLNINDKVVSLEKQLLEMEQSYKTETENTQKL----------KKHNAELDFTVKSQE 597
                      :::.|:..||::|.:.:...:...::..|:          |::|:|::    |:.
 Worm   478 ----------SLSTKISDLERELKDNKDKLRHGADSDAKVNELAVELRMSKEYNSEME----SEL 528

  Fly   598 EKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIERTMCR 662
            .|.||..:.:      ||:|.:::.||    .||||...::.:..|:|:.....:..|.|....|
 Worm   529 SKFRDKCEQL------KEDLRKKSGEL----AQEKNETQRVFQQKKDADEAFAEIKRDYELLQTR 583

  Fly   663 EQKAQEDNRALLEKISDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANLQEVKAL 727
            |.          ||...|:||     .:.:...|.|||.|....:.|..|.:...|..|:..
 Worm   584 EN----------EKSVQLKKA-----LDERKENGAYQQSVAKATDAEWERKMQFYEKQLEHA--- 630

  Fly   728 QSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHS 792
                |:|:.                                     |:|.::.||   :.||...
 Worm   631 ----NDERK-------------------------------------REEQKRTAA---EFDQSRV 651

  Fly   793 KRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQL 857
            .|            ::|.:.:....||.:..:.:||::..|.||       .:.:...|.|:.::
 Worm   652 AR------------KLAGIEANYELLQNDYKSMKEARKDLERDL-------QDVITEKRRLEIRV 697

  Fly   858 E----AEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEE 918
            |    :.....|:.....:|..|...|...|.:.|..:....||::       ::|.:.....||
 Worm   698 EQLMDSRNTDERVLSLCQDELVESQEEAKYKEDGLRGKIDGFKHEL-------ENEKMKTQTLEE 755

  Fly   919 TVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQ 983
            .:...:||:.:.::|:::.:.:|:.||..|:   .|||..|.:|           :::.||.|.:
 Worm   756 NLLVADKERGMLKMEVQELMQRHKWEITNKD---QTLKHLETQL-----------DEIKQQSKIE 806

  Fly   984 QEELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAEVMNRRDSDLP-KQKNKARSTAELRKKE 1047
            ..|   ..|:..:.|..|..|...|...|:..:|||.|.|.:|.   | |:..|..:.:.|.|||
 Worm   807 SSE---QESNDKQTIADLRKKLDLEKAHKKAVINKLEEEMAKRQ---PLKKGEKGVTKSALIKKE 865

  Fly  1048 KEMRRLQQE----------LSQERDK----FNQLLLKHQDLQQLCAEEQQLKQKMVMEIDCKATE 1098
            :|:..|:||          |..|.||    ||..:...|..|....:|  ||       :|| .|
 Worm   866 REIMALEQERDTMSKRIAALFYENDKQAEHFNIAIQDMQTTQDALRDE--LK-------ECK-EE 920

  Fly  1099 I--ENLQSKLNETASLSSADNDPE--DSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYV 1159
            :  .|:.::..:..||.|.:..|.  .:||..:         |||||:.:...:.|...|...:|
 Worm   921 LANRNVNTRYEDKRSLDSREGIPSSLSNQHIQM---------EGWLSLRDNTKKSRKPKWTNCFV 976

  Fly  1160 IVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASH 1224
            .::......|   :|: .....:|:::...:.|||.||..|:...|..::|:||.::| .:.:.:
 Worm   977 ALNEYSFTIY---VDE-KAVSVILLIEAGAMAHVRHVTAADLRNVDDSQLPKIFHIMY-DDASCN 1036

  Fly  1225 RPDEQSQLDVSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRC 1289
            .....|..|:|::.....|.      .|.|:|..::||:.|.|:||.|.|..:.:|..|:|||.|
 Worm  1037 SSRHASNSDLSMIESFREES------WKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNC 1095

  Fly  1290 RNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQKSGYKAASYNNNS 1354
            ..|.||:|| ....|..|:.|  ...:|:::|:|...::.:.||::|.:.|:.|  ::|:.:.:.
 Worm  1096 HFKTHKDHV-AQGSLPMCRYN--TGLSRELVLMAPQTDNCNKWVSQLRRFIESS--RSAAVSVSR 1155

  Fly  1355 TDGSKISPSQSTRSS 1369
            ....:.:|..|..|:
 Worm  1156 VSSRRHAPGSSNSST 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	210/350 (60%)
		Smc	527..>1121	CDD:440809	134/626 (21%)
		ROCK_SBD	849..920	CDD:409019	14/74 (19%)
		PH_ROCK	1134..1250	CDD:269948	26/115 (23%)
		C1_ROCK	1247..1310	CDD:410363	24/62 (39%)
let-502	NP_491440.1	Protein Kinases, catalytic domain	41..393	CDD:473864	210/351 (60%)
		CCDC158	<438..>983	CDD:464943	151/715 (21%)
		PH-like	951..1056	CDD:473070	25/118 (21%)
		C1_ROCK	1053..1115	CDD:410363	25/68 (37%)