DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Lats1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	NP_034820.1	Gene:	Lats1 / 16798	MGIID:	1333883	Length:	1129	Species:	Mus musculus

Alignment Length:	509	Identity:	157/509 - (30%)
Similarity:	250/509 - (49%)	Gaps:	107/509 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ETVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKY 70
            |.|.|.....:.|:::   ||.||               :...:|....:.:|::  :.|..:.|
Mouse   647 ENVLKSHQQRLHRKKQ---LENEM---------------MRVGLSQDAQDQMRKM--LCQKESNY 691

  Fly    71 KPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEE 135
                :::.:.:|:...|..||.:|.||||||.|.|...:..:||.|.|.|.:::.|...|....|
Mouse   692 ----IRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 752

  Fly   136 RHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSL---MGDYDIPEKWAIFYTMEVVLAL 197
            |.|:|.|::||:|:|:::|||...||.|||::||||::||   ||.:  ||..|.||..|:..|:
Mouse   753 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIF--PENLARFYIAELTCAV 815

  Fly   198 DTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC------------------------------- 231
            :::|.|||:|||:||||:|:|..||:||.|||.|
Mouse   816 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGD 880

  Fly   232 ---MRMG------------ANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYE 281
               .|.|            .:.:.::.:.||||:||:||||...|    |.:.|||||||:.|:|
Mouse   881 PSNCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----YTQLCDWWSVGVILFE 941

  Fly   282 MLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAH 346
            ||.|:.||.|.:.:.|..|:::.:.||..||:.::|.:|..||.........|||:.|.::||||
Mouse   942 MLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAH 1006

  Fly   347 PFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD-----------------------EKP 388
            |||:...:|.| :|:.....:|:::...||.||:.::.|                       :.|
Mouse  1007 PFFKTIDFSSD-LRQQSASYIPKITHPTDTSNFDPVDPDKLWSDGSEEENISDTLNGWYKNGKHP 1070

  Fly   389 EEV---FPVPKGFDGNHLPFIGFTYTGDYQLLSSDTVDAESKEANVANSGAASN 439
            |..   |...:.||.|..|: .:....:|:.:.|...:.:|.|.:...|...:|
Mouse  1071 EHAFYEFTFRRFFDDNGYPY-NYPKPIEYEYIHSQGSEQQSDEDDQHTSSDGNN 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	141/424 (33%)
		S_TKc	87..349	CDD:214567	120/310 (39%)
		SbcC	484..1088	CDD:223496
		Rho_Binding	963..1027	CDD:286056
		PH_ROCK	1134..1250	CDD:269948
		C1	1254..1307	CDD:197519
Lats1	NP_034820.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		UBA_like_SF	103..143	CDD:304366
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	148..216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	228..276
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..317
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..407
		PPxY motif 1	372..375
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	432..492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..630
		Interaction with YAP1. /evidence=ECO:0000250	525..654		3/6 (50%)
		PPxY motif 2	555..558
		STKc_LATS1	702..1083	CDD:270775	134/387 (35%)
		S_TKc	704..1009	CDD:214567	120/310 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1104..1129		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920