DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Cit

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_006530193.1	Gene:	Cit / 12704	MGIID:	105313	Length:	2123	Species:	Mus musculus

Alignment Length:	1719	Identity:	414/1719 - (24%)
Similarity:	685/1719 - (39%)	Gaps:	518/1719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVR 105
            :||.:.||..:|...:|.::|::..:..||.....::.:|:.:..||....|:|.|.|.|||:||
Mouse    51 MLDALFALFEECSQPALMKMKHVSSFVQKYSDTIAELRELQPSARDFEVRSLVGCGHFAEVQVVR 115

  Fly   106 HKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGG 170
            .|::..|||||.:.|..::.:...:||.|||:|::.:.|.||.||.:||||...||:||::.|||
Mouse   116 EKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGG 180

  Fly   171 DIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMR 233
            |::||:..|:  :.|....||..|::||:.::|.||:||||:||:|:|:|..||:||.|||:..:
Mouse   181 DLLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAK 245

  Fly   234 MGANGQVVSSNAVGTPDYISPEVLQSQGVDNE--YGRECDWWSVGIFLYEMLFGETPFYADSLVG 296
            |.:| :|.:...:|||||::||||.....|..  ||.:|||||||:..|||::|:|||...:...
Mouse   246 MNSN-KVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEGTSAR 309

  Fly   297 TYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRE 361
            |:..||:.:..|.||.:.::|.:...|:::.|..:.:||   ..|.:..||||....|  :|||.
Mouse   310 TFNNIMNFQRFLKFPDDPKVSSELLDLLQSLLCVQKERL---KFEGLCCHPFFARTDW--NNIRN 369

  Fly   362 SVPPVVPELSSDDDTRNFEDIERDE-KPEEVFPV-PKGFDGNHLPFIGFTYTG--DYQLLSSDTV 422
            |.||.||.|.|||||.||::.|::. ....|..: |.||.|..|||:||:|:.  .|...|...|
Mouse   370 SPPPFVPTLKSDDDTSNFDEPEKNSWVSSSVCQLSPSGFSGEELPFVGFSYSKALGYLGRSESVV 434

  Fly   423 DAESKEANVAN--------SGAASNNHGHGH------NHRHRPSNSNELKRLEALLERERGRSEA 473
            .:....|.|::        |....::....|      ...||     .:..:||:|.::....:|
Mouse   435 SSLDSPAKVSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHR-----RVSEVEAVLSQKEVELKA 494

  Fly   474 LEQQDAGLRQQI-ELIT-----KREAELQRIASEYEKDLALR-QHNYKVAMQKV----EQEIE-- 525
            .|.|.:.|.|.: ..||     ||..|..|:....|.|.||: .|:.:...:|:    |||.:
Mouse   495 SETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQAQ 559

  Fly   526 ------LRKKTEALLVETQRNLE------NEQKTRARDL--NIND------KVVS---------- 560
                  :..:.|..||..:|..:      .|.:..|.:.  ..|:      ||||
Mouse   560 VEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKANECQHKLMKVVSHPPRGDSGGT 624

  Fly   561 ----LEKQ-----LLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEK----VRDMVDMIDTLQK 612
                |.|.     |...:...|.|.....||:|.|||....::..:||    |:...:..:.||.
Mouse   625 ALDDLHKMQGHAGLTSAKDQGKPEVGEYSKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQN 689

  Fly   613 HKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDIER--TMCREQKAQEDN----- 670
            .::...:...||:.|..:|.:... :|:...|||.:..:|.|.::|  ||.|.:...:|:
Mouse   690 IRQAKERAERELEKLHNREDSSEG-IKKKLVEAEERRHSLENKVKRLETMERRENRLKDDIQTKS 753

  Fly   671 ---RALLEKISDLEKAH-------AGLDFELKAAQGRYQQEVKA--------------------- 704
               :.:.:||.:||:.|       ..|:..||..:..|::::|.
Mouse   754 EQIQQMADKILELEEKHREAQVSAQHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKESLENMMQR 818

  Fly   705 HQET--EKSRLVSREEANL----QEVKALQSKLNEEKSARIKADQHSQEKER----QLSMLSVDY 759
            |:|.  ||.:::|.::|.:    .::::|:.::.|...|...|...|...:|    |..|:| :.
Mouse   819 HEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS-EL 882

  Fly   760 RQIQLRLQKLEGECRQESEKVAALQSQLD----QEHSKRNALLS------ELSLHSSE------- 807
            ||.:..|:...|:...::.|   |:.||:    |:||.::.||.      |:||...|
Mouse   883 RQQKFYLETQAGKLEAQNRK---LEEQLEKISHQDHSDKSRLLELETRLREVSLEHEEQKLELKR 944

  Fly   808 -----VAHLRSRENQL------QKELSTQ-REAKRRFEEDLTQLKSTHHEALANNRELQAQLEA- 859
                 ...|:.||:||      :..|.:| |:||...||...:.:.......|:..|:|.:.:|
Mouse   945 QLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDAL 1009

  Fly   860 ----------EQCFSRLYKTQA---NEN-------------REESAERLSKIE----DLEEERVS 894
                      |:..::|.:..|   |:|             .:|..:..|:::    ::.|..:.
Mouse  1010 RNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQ 1074

  Fly   895 LKHQVQVAVARAD---SEALAR--SIAEETVAD--------LEKEK------------------T 928
            |..|.|..::..|   .|||..  ::.||.|.|        ||||:                  .
Mouse  1075 LTSQKQAQLSAPDLQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEKSQFECR 1139

  Fly   929 IKELE-----------------------LKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKA 970
            ::||:                       ::..|.:|:.||.|.:.||...|.....|..||....
Mouse  1140 VRELQRMLDTEKQSRARADQRITESRQVVELAVKEHKAEILALQQALKEQKLKAESLSDKLNDLE 1204

  Fly   971 AEYEDLVQQHKKQQEELALMRSSKD---EEITKL---LDKCKNEVL-LKQVAVNKLAEVMNRRD- 1027
            .::..|....:..|::|...|..|.   ||..||   :|..||.:. |.|    .|.|.::|.|
Mouse  1205 KKHAMLEMNARSLQQKLETERELKQRLLEEQAKLQQQMDLQKNHIFRLTQ----GLQEALDRADL 1265

  Fly  1028 -----SDLPKQ---------KNKARSTAELRKKEKEMRRLQQELSQERDK--------------- 1063
                 |||..|         ..|.:....:.::.|.:..||.::.|...|
Mouse  1266 LKTERSDLEYQLENIQVLYSHEKVKMEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALP 1330

  Fly  1064 ------FNQLLLKHQDLQQLCAEEQQLKQKMVMEIDC--------KATEIEN------LQSKLNE 1108
                  :|:|.|..:..:..|||.::..||..:|:..        |||:..:      .:.::..
Mouse  1331 TQVPLQYNELKLALEKEKARCAELEEALQKTRIELRSAREEAAHRKATDHPHPSTPATARQQIAM 1395

  Fly  1109 TASLSSADNDPE----------------------------------------------------D 1121
            :|.:.|.::.|.                                                    |
Mouse  1396 SAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEFSRRLKERMHHNIPHRFNVGLNMRATKCAVCLD 1460

  Fly  1122 SQH-------------------SSLLSLT----------------QDSV---------------F 1136
            :.|                   |:.|..|                :|.:               .
Mouse  1461 TVHFGRQASKCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFCRDKMNSPGLQSKEPGSSLHL 1525

  Fly  1137 EGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDV 1201
            |||:.|| :.|:|...||.|:|:::...|::.|::
Mouse  1526 EGWMKVP-RNNKRGQQGWDRKYIVLEGSKVLIYDN------------------------------ 1559

  Fly  1202 IRADAKEIPRIFQLLYAGEGASHRPDEQSQL-----DVSVLHGNCN------------------E 1243
               :|:|             |..||.|:.:|     |||: ||...                  |
Mouse  1560 ---EARE-------------AGQRPVEEFELCLPDGDVSI-HGAVGASELANTAKADVPYILKME 1607

  Fly  1244 ERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCK 1308
            ..|.|....|.....:....|      .|..|     ..|.|......::.:|..:..
Mouse  1608 SHPHTTCWPGRTLYLLAPSFP------DKQRW-----VTALESVVAGGRVSREKAEAD------- 1654

  Fly  1309 LNHDPRSARDMLLLAATPEDQSLWVARLL 1337
                  :|||    ..:.|.|.:||.:||
Mouse  1655 ------AARD----HTSSEHQPVWVEKLL 1673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	146/355 (41%)
		S_TKc	87..349	CDD:214567	111/265 (42%)
		SbcC	484..1088	CDD:223496	186/864 (22%)
		Rho_Binding	963..1027	CDD:286056	19/70 (27%)
		PH_ROCK	1134..1250	CDD:269948	28/153 (18%)
		C1	1254..1307	CDD:197519	6/52 (12%)
Cit	XP_006530193.1	STKc_CRIK	96..421	CDD:270752	142/330 (43%)
		Smc	473..1372	CDD:224117	198/912 (22%)
		C1	1442..1490	CDD:237996	4/47 (9%)
		PH	1523..1642	CDD:214574	34/177 (19%)
		CNH	1687..1983	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820