DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and Cdc42bpa

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_038946162.1	Gene:	Cdc42bpa / 114116	RGDID:	621406	Length:	1849	Species:	Rattus norvegicus

Alignment Length:	1336	Identity:	390/1336 - (29%)
Similarity:	630/1336 - (47%)	Gaps:	262/1336 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RANTLEREMRDPTSICNVDC-----LLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQL 80
            |...||:.:.|..:..|..|     |||.:..|..:|::..|||.|||.:|....||...::.|:
  Rat     6 RLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQM 70

  Fly    81 RMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSE 145
            |::.|||..:|:||.||||||.:|:.|::.:|:|||.|:|:||:||.::|.|.|||.::.:.:|:
  Rat    71 RLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDSK 135

  Fly   146 WIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHR 208
            ||..||:||||...||:|||:..|||:::|:..::  :||:.|.||..|:|:|:|::|.:.:|||
  Rat   136 WITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHR 200

  Fly   209 DVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS-QGVDNEYGRECDW 272
            |:||||:|:|..||::|||||:|:::..:|.|.||.|||||||||||:||: :.....||.||||
  Rat   201 DIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDW 265

  Fly   273 WSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEV-EISEQAKALIRAFLTDRTQRLG 336
            ||:|:.:||||:|||||||:|||.||||||:||....||.:| ::||.||.|||..:..|..|||
  Rat   266 WSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPTQVTDVSENAKDLIRRLICSREHRLG 330

  Fly   337 RYGIEDIKAHPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERD-EKPEEVFPVP--KGF 398
            :.||||.|.||||....|  ||||....|.:||:||..||.|| |::.| .|..|..|.|  ..|
  Rat   331 QNGIEDFKKHPFFSGIDW--DNIRNCEAPYIPEVSSPTDTSNF-DVDDDCLKNSETMPPPTHTAF 392

  Fly   399 DGNHLPFIGFTYTGDYQLLSSD------TVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNEL 457
            .|:||||:|||||....|  ||      |....|.:.:|.......||..       ..:....:
  Rat   393 SGHHLPFVGFTYTSSCVL--SDRSCLRVTAGPTSLDLDVNVQRTLDNNLA-------TEAYERRI 448

  Fly   458 KRLE-ALLERERGRSEALEQQDA-------------------GLRQQIELITKREAELQRIASEY 502
            |||| ..||..|...|:.:...|                   .|:::||.:.|:.||:..:..:.
  Rat   449 KRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNHLEQQL 513

  Fly   503 EK--------DLALRQHNYKVAMQKVEQEIE-LRKKTEAL---LVETQRNLENEQKTRARDLNIN 555
            |:        |.|.||      ::..|::|: |:::.|.|   ||:....|:|:.| ..:|.:..
  Rat   514 EEANSVRRELDDAFRQ------IKAFEKQIKTLQQEREELNKELVQASERLKNQSK-ELKDAHCQ 571

  Fly   556 DKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDFTVKSQEEKVRDMVDMIDTL-------QKH 613
            .|:..  ::.:|:.:.........|||.:|       |:.:||:|..::...::|       ::.
  Rat   572 RKLAM--QEFMEINERLTELHTQKQKLARH-------VRDKEEEVDLVMQKAESLRQELRRAERA 627

  Fly   614 KEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLIN---DIERTMCREQKAQEDNRALLE 675
            |:||......|.|...:::.||.|.:...|:.||:::.|..   .....:|..:..||     :.
  Rat   628 KKELEVHTEALIAEASKDRKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEHQQE-----IT 687

  Fly   676 KI-SDLEKAHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSREEANL---QEVKALQSKLNEEKS 736
            |: :||||.....:.|:...:|.:..|:|    ..|..|...|...|   :|:..|:.||
  Rat   688 KLKTDLEKKSIFYEEEISKREGIHASEIK----NLKKELHDSEGQQLALNKEIMVLKDKL----- 743

  Fly   737 ARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALLSEL 801
                      ||.|         |:.|...::.|.|.:|:.|:...|   |.:|:.|   |.|||
  Rat   744 ----------EKTR---------RESQSEREEFENEFKQQYEREKVL---LTEENKK---LTSEL 783

  Fly   802 SLHSSEVAHLRSRENQLQ---KELSTQREAKRRFEEDLTQL---------KSTHHEALANNRELQ 854
            ...:|....|..|...|:   |:|:.::|:...:|..:|::         ...:.:|||:  ::.
  Rat   784 DKLTSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALAS--KMT 846

  Fly   855 AQLEAEQCFSRLYKTQANENREESAERLSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEET 919
            .:|||.:..|  ..|:|.: ......|.:|::      :|.:.::|.|:   |:|..|:...:|.
  Rat   847 EELEALRNSS--LGTRATD-MPWKMRRFAKLD------MSARLELQSAL---DAEIRAKQAIQEE 899

  Fly   920 VADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQ 984
            :..::....|.|.:|||...|:...::..|..:...:|..:|       |..|:.|      .|.
  Rat   900 LNKVKASNIITECKLKDSEKKNLELLSEIEQLIKDTEELRSE-------KGVEHRD------SQH 951

  Fly   985 EELALMRSSKDEEITKLLDKCKNEVLLKQVAVNKLAE--VMNRRDSDLPKQKNK----------- 1036
            ..||.:.:..|     .||:.::.......::....:  .::|..|..|..|.:
  Rat   952 SFLAFLNTPTD-----ALDQFEDSFSSSSSSLIDFLDDLFLDRSPSCTPAGKGRRTEPVDNTYIR 1011

  Fly  1037 ---------ARSTAELRKKEKEMRRLQQELS-------------------QERDKFNQLLLK--- 1070
                     .|.|:.....|.|..::.....                   ..:.|.:|..:|
  Rat  1012 NPSVKLYIQQRPTSPSTPSEAEPVKIADSAPLPVHTPTLRKKGCPASAGFPPKRKTHQFFVKSFT 1076

  Fly  1071 -----HQD-------LQQLCAEEQQLKQKMVMEIDCKATEIENLQSKLNETASLSSADN------ 1117
                 ||.       ::|.|:.|       |....|..|.:    :|...|..:.....
  Rat  1077 APTKCHQCTSLMVGLIRQGCSCE-------VCGFSCHITCV----NKAPTTCPVPPEQTKGPLGI 1130

  Fly  1118 DPEDSQHSSLLSLTQDSVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAV 1182
            ||:..         ..:.:||.:.:|.....::  ||:|...:|...|:..|:....|.:...:|
  Rat  1131 DPQKG---------VGTAYEGHVRIPKPAGVKK--GWQRALAVVCDFKLFLYDIAEGKASQPSSV 1184

  Fly  1183 L--ILDL-SKVYHVRSVTQGDVIRADAKEIPRIFQL 1215
            :  ::|: .:.:.|.||...|||.|..|:||.||::
  Rat  1185 ISQVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRV 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	183/356 (51%)
		S_TKc	87..349	CDD:214567	142/265 (54%)
		SbcC	484..1088	CDD:223496	142/697 (20%)
		Rho_Binding	963..1027	CDD:286056	10/65 (15%)
		PH_ROCK	1134..1250	CDD:269948	24/85 (28%)
		C1	1254..1307	CDD:197519
Cdc42bpa	XP_038946162.1	STKc_MRCK_alpha	4..412	CDD:270773	200/410 (49%)
		SbcC	<442..958	CDD:223496	133/597 (22%)
		KELK	530..608	CDD:406277	20/87 (23%)
		C1	1066..1125	CDD:412127	13/69 (19%)
		PH_MRCK	1127..1261	CDD:269949	26/105 (25%)
		CNH	1287..1551	CDD:395630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820