DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and CIT

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_011536085.1	Gene:	CIT / 11113	HGNCID:	1985	Length:	2084	Species:	Homo sapiens

Alignment Length:	1686	Identity:	408/1686 - (24%)
Similarity:	686/1686 - (40%)	Gaps:	489/1686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVR 105
            :||.:..|..:|...:|.::|::..:..||.....::.:|:.:.:||....|:|.|.|.|||:||
Human    51 ILDALFVLFEECSQPALMKIKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGHFAEVQVVR 115

  Fly   106 HKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGG 170
            .|::..:||||.:.|..::.:...:||.|||:|::.:.|.||.||.:||||..:||:||::.|||
Human   116 EKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNHLYLVMEYQPGG 180

  Fly   171 DIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMR 233
            |::||:..|:  :.|....||..|::||:.::|.||:||||:||:|:|:|..||:||.|||:..:
Human   181 DLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKPENILVDRTGHIKLVDFGSAAK 245

  Fly   234 MGANGQVVSSNAVGTPDYISPEVLQSQGVDNE--YGRECDWWSVGIFLYEMLFGETPFYADSLVG 296
            |.:|..|.:...:|||||::||||.....|.:  ||.:|||||||:..|||::|.:||...:...
Human   246 MNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSAR 310

  Fly   297 TYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWSFDNIRE 361
            |:..||:.:..|.||.:.::|.....||::.|..:.:||   ..|.:..||||....|  :|||.
Human   311 TFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERL---KFEGLCCHPFFSKIDW--NNIRN 370

  Fly   362 SVPPVVPELSSDDDTRNFEDIERD----EKPEEVFPVPKGFDGNHLPFIGFTYTGDYQLLS-SDT 421
            |.||.||.|.|||||.||::.|::    ..|.::  .|.||.|..|||:||:|:....:|. |::
Human   371 SPPPFVPTLKSDDDTSNFDEPEKNSWVSSSPCQL--SPSGFSGEELPFVGFSYSKALGILGRSES 433

  Fly   422 V----DAESKEAN-----VANSGAASNNHGHGH------NHRHRPSNSNELKRLEALLERERGRS 471
            |    |:.:|.::     :..|....::....|      ...||     .:..:||:|.::....
Human   434 VVSGLDSPAKTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHR-----RVSEVEAVLSQKEVEL 493

  Fly   472 EALEQQDAGLRQQI-ELIT-----KREAELQRIASEYEKDLALR-QHNYKVAMQKV----EQEIE 525
            :|.|.|.:.|.|.: ..||     ||..|..|:....|.|.||: .|:.:...:|:    |||.:
Human   494 KASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLHDIREQSRKLQEIKEQEYQ 558

  Fly   526 --------LRKKTEALLVETQRN---LENE-QKTRARDLNINDKVVSLEKQLLEMEQSYKTETEN 578
                    :..:.|..||..:|.   .|:| :::|........|....:.:||:.:...|.|...
Human   559 AQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKATECQHKLLKAKDQGKPEVGE 623

  Fly   579 TQKLKKHNAELDFTVKSQEEKVRDMV-------DMIDTLQKHKEELGQENAELQALVVQEKNLRS 636
            ..||:|.|||....::..:||:...|       :::..:::.||...:|..:||......:.:|.
Human   624 YAKLEKINAEQQLKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDSSEGIRK 688

  Fly   637 QLKEMHKEAENKMQTLINDIER--TMCREQKAQEDN--------RALLEKISDLEKAH------- 684
            :|    .|||.:..:|.|.::|  ||.|.:...:|:        :.:.:||.:||:.|
Human   689 KL----VEAEERRHSLENKVKRLETMERRENRLKDDIQTKSQQIQQMADKILELEEKHREAQVSA 749

  Fly   685 AGLDFELKAAQGRYQQEVKA---------------------HQET--EKSRLVSREEANL----Q 722
            ..|:..||..:..|::::|.                     |:|.  ||.:::|.::|.:    .
Human   750 QHLEVHLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEEAHEKGKILSEQKAMINAMDS 814

  Fly   723 EVKALQSKLNEEKSARIKADQHSQEKER----QLSMLSVDYRQIQLRLQKLEGECRQESEKVAAL 783
            ::::|:.::.|...|...|...|...:|    |..|:| :.||.:..|:...|:...::.|   |
Human   815 KIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMIS-ELRQQKFYLETQAGKLEAQNRK---L 875

  Fly   784 QSQLD----QEHSKRNALLS------ELSL-HSSEVAHLRSRENQLQ-------KELSTQREAKR 830
            :.||:    |:||.:|.||.      |:|| |..:...|:.:..:||       .:|:..:.|:.
Human   876 EEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARA 940

  Fly   831 RFEEDLTQLKSTHHEALAN-NRELQA----QLEAEQCFSRL---------YKTQANENREESAE- 880
            ..|..|.|.|:...|..|. ..|:||    :.|.::.|..|         .:.|.|:..|::||
Human   941 ALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDALRNSCTVITDLEEQLNQLTEDNAEL 1005

  Fly   881 ---------RLSKIEDLEEERVSLKHQV------------QVAVARADSEALAR--SIAEETVAD 922
                     :|.:.....:|.|.|:.:|            |:...:...|||..  ::.||.|.|
Human  1006 NNQNFYLSKQLDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMD 1070

  Fly   923 --------LEKEK------------------TIKELE-----------------------LKDFV 938
                    ||||:                  .::||:                       ::..|
Human  1071 LEALNDELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAV 1135

  Fly   939 MKHRNEINAKEAALATLKEAENELHKKLGQKAAEYEDLVQQHKKQQEELALMRSSKD---EEITK 1000
            .:|:.||.|.:.||...|.....|..||.....::..|....:..|::|...|..|.   ||..|
Human  1136 KEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLLEEQAK 1200

  Fly  1001 L---LDKCKNEVL-LKQVAVNKLAEVMNRRD------SDLPKQ---------KNKARSTAELRKK 1046
            |   :|..||.:. |.|    .|.|.::|.|      |||..|         ..|.:....:.::
Human  1201 LQQQMDLQKNHIFRLTQ----GLQEALDRADLLKTERSDLEYQLENIQVLYSHEKVKMEGTISQQ 1261

  Fly  1047 EKEMRRLQQELSQERDK---------------------FNQLLLKHQDLQQLCAEEQQLKQKMVM 1090
            .|.:..||.::.|...|                     :|:|.|..:..:..|||.::..||..:
Human  1262 TKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYNELKLALEKEKARCAELEEALQKTRI 1326

  Fly  1091 EIDC--------KATEIEN------LQSKLNETASLSSADNDPE--------------------- 1120
            |:..        |||:..:      .:.::..:|.:.|.::.|.
Human  1327 ELRSAREEAAHRKATDHPHPSTPATARQQIAMSAIVRSPEHQPSAMSLLAPPSSRRKESSTPEEF 1391

  Fly  1121 -------------------------------DSQH-------------------SSLLSLT---- 1131
                                           |:.|                   |:.|..|
Human  1392 SRRLKERMHHNIPHRFNVGLNMRATKCAVCLDTVHFGRQASKCLECQVMCHPKCSTCLPATCGLP 1456

  Fly  1132 ------------QDSV---------------FEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFY 1169
                        :|.:               .|||:.|| :.|:|...||.|:|:::...|::.|
Human  1457 AEYATHFTEAFCRDKMNSPGLQTKEPSSSLHLEGWMKVP-RNNKRGQQGWDRKYIVLEGSKVLIY 1520

  Fly  1170 NSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQL-- 1232
            ::                                 :|:|             |..||.|:.:|
Human  1521 DN---------------------------------EARE-------------AGQRPVEEFELCL 1539

  Fly  1233 ---DVSVLHGNCN------------------EERPGTIVHKGHEFVHITYHMPTACEVCPKPLWH 1276
               |||: ||...                  |..|.|....|.....:....|      .|..|
Human  1540 PDGDVSI-HGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYLLAPSFP------DKQRW- 1596

  Fly  1277 MFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLL 1337
                ..|.|......::.:|..:..             :|||.:.....|    .||.:||
Human  1597 ----VTALESVVAGGRVSREKAEAD-------------AARDCVSYELLP----AWVQKLL 1636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	145/357 (41%)
		S_TKc	87..349	CDD:214567	110/265 (42%)
		SbcC	484..1088	CDD:223496	183/829 (22%)
		Rho_Binding	963..1027	CDD:286056	19/70 (27%)
		PH_ROCK	1134..1250	CDD:269948	28/153 (18%)
		C1	1254..1307	CDD:197519	6/52 (12%)
CIT	XP_011536085.1	STKc_CRIK	95..422	CDD:270752	141/333 (42%)
		S_TKc	97..360	CDD:214567	110/265 (42%)
		Smc	474..1335	CDD:224117	195/877 (22%)
		C1	1405..1453	CDD:237996	4/47 (9%)
		PH	1486..1605	CDD:278594	34/177 (19%)
		CNH	1650..1946	CDD:214481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0612
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D759391at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820