DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rok and rock1

DIOPT Version :9

Sequence 1:	NP_536796.2	Gene:	Rok / 43916	FlyBaseID:	FBgn0026181	Length:	1390	Species:	Drosophila melanogaster
Sequence 2:	XP_021334267.1	Gene:	rock1 / 100329779	ZFINID:	ZDB-GENE-100712-2	Length:	1375	Species:	Danio rerio

Alignment Length:	1418	Identity:	602/1418 - (42%)
Similarity:	847/1418 - (59%)	Gaps:	129/1418 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RANTLEREMRDPTSICNVDCLLDTVSALVSDCDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVE 85
            |...::..::||.|..|.|||||::.|||.|.|..:||:.|:|:.:..:||....:|.:|||..|
Zfish    12 RFEKIDAMLKDPKSEVNTDCLLDSLDALVYDLDFPALRKNKSIDDFLKRYKDTISKIRELRMKAE 76

  Fly    86 DFHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQL 150
            |:..:|:||.||||||||||||::.:|||||.||||||:||.|||||||||.|||.|||.|:|||
Zfish    77 DYEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQL 141

  Fly   151 HFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNM 215
            .:||||.:||||||::|||||:|:||.:||:|||||.|||.|||||||.||:|||:|||||||||
Zfish   142 FYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNM 206

  Fly   216 LLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLY 280
            |||..||||||||||||:|..:|.|....|||||||||||||:|||.|..|||||||||||:|||
Zfish   207 LLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLY 271

  Fly   281 EMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKA 345
            |||.|:||||||||||||.|||:|||:|:||.:.:||:.||:||.||||||..||||.|:::||.
Zfish   272 EMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKR 336

  Fly   346 HPFFRNDTWSFDNIRESVPPVVPELSSDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLPFIGFTY 410
            |.||:||.|:::||||:..|||||||.|.||.||:|||.|...||.||:||.|.||.|||:||||
Zfish   337 HGFFKNDQWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTY 401

  Fly   411 TGDYQLLSSDTVDAESKEANVANSGAASNNHGHGHNHRHRPSNSNELKRLEALLERERGRSEALE 475
            ..:.......|:....|.::.....:...|            ....:.:||..:..|....:.:|
Zfish   402 YSNNLFSQESTIKTSDKRSSTKEDKSLLEN------------LQKRIYQLEEQVHSEMQLRDEME 454

  Fly   476 QQDAGLRQQIELITK---REAELQRIA----SEYEKDLALRQHNYKVAMQKVEQEIELRKKTEAL 533
            |:......:::.|.|   .|:.|::..    |..|||..:.||......:|.:||.|.|
Zfish   455 QKCRASNTKLDKIMKELDEESNLRKSVEANMSILEKDKIMIQHRATEYQRKADQEAEKR------ 513

  Fly   534 LVETQRNLENEQKTRARDL-------NINDKVVSLEKQLLEMEQSYKTETENTQKLKKHNAELDF 591
                 ||||||..|....|       ..|||:..|:.||.|.....:.|::...:|:|.:.|:..
Zfish   514 -----RNLENEVSTLKEQLEDLRKISQNNDKIAQLQNQLGEANDLLRAESDTVMRLRKSHTEMGK 573

  Fly   592 TVKSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQEKNLRSQLKEMHKEAENKMQTLINDI 656
            |:...|...|::.:.|...:..|::|.:|..:||..:..|:...||..|..:|.:.::..|..|.
Zfish   574 TMSQLESINRELQEKIRAAESVKQQLEKELLQLQTTLDTERRSCSQGSEEIRELQVRIMGLQEDN 638

  Fly   657 ERTMCREQKAQEDNRALLEKISDLEK----AHAGLDFELKAAQGRYQQEVKAHQETEKSRLVSR- 716
            :.......|.:.:.:.:.|:.:.|||    ....|:::||..|.|..||:..|:.| |::|..:
Zfish   639 KNLKQSLTKVETERKHVQERCNILEKEKNSLEIDLNYKLKTLQQRLDQELTEHRIT-KAQLTDKY 702

  Fly   717 ---EEANLQEVKALQSKLNEEKSARIKADQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESE 778
               ||:....:.|::.|::||.:.|::|:....|.|:|.|||..|.:|...::::|..:..:..:
Zfish   703 ESIEESKSAAMHAVEQKVSEETTLRMRAESRVVEVEKQCSMLEFDLKQSVQKMEQLMKQKERLED 767

  Fly   779 KVAALQSQLDQEHSKRNALLSELSLHSSEVAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTH 843
            :|..|:.||:||..||....:||.....:...|:..|.||::|::...|.||..|..|.||...:
Zfish   768 EVKDLRVQLEQETGKRVMSQNELKNWKMDSERLKGTEKQLKQEINAALENKRSVEFQLAQLTKQY 832

  Fly   844 HEALANNRELQAQLEAEQCFSRLYKTQANENREE-------SAERLSKIEDLEEERVSLKHQVQV 901
            .......||||.||||||.||.|||||..|.::|       :.|.|.:::||..|:.||..|:.:
Zfish   833 RGNEGQMRELQDQLEAEQYFSTLYKTQVKELKDEIEEKNRQTQEALKRVQDLNSEKESLSAQLDL 897

  Fly   902 AVARADSEALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKK- 965
            .:.:|:||.|||::.||...:|.:       |.|..|.:::.||:.|::.::.|:::...|.|.
Zfish   898 TMTKAESEQLARALQEEQYVELSQ-------EYKKAVSRYKQEISEKDSTISQLEDSNKTLTKDV 955

  Fly   966 --LGQKAAEYEDLVQQHKKQQEELALMRSSKDEEITKLLDKCKN-EVLLKQVAVNKLAEVMNRRD 1027
              |.::..|:.:.:|   .|::|.|..|......|....:|..| |..||..|||||||:|||:|
Zfish   956 EILSKEKTEFNERIQ---AQEQEFAAEREELTNSIKANYEKALNIERTLKTQAVNKLAEIMNRKD 1017

  Fly  1028 SDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQQLCAEEQQLKQKM 1088
            .   |.:.|..||.:|||||||.|:||.||:||::|||.:..|:|    ::|...|||...:.::
Zfish  1018 M---KDQKKRGSTTDLRKKEKENRKLQLELNQEKEKFNHMAFKYQKELNEMQAQWAEECTYRNEL 1079

  Fly  1089 VMEIDCKATEIENLQSKLN------ETASLSSADNDPEDSQHSSLLSLTQDSVFEGWLSVPNKQN 1147
            .|::|.|.::||.|:.|||      :.:|::|...|..||.       ..:|..||||::||:.|
Zfish  1080 QMQLDSKESDIEQLREKLNDLQLRVDNSSVTSLQPDELDSN-------IAESRLEGWLAIPNRAN 1137

  Fly  1148 RRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRI 1212
            .:| :|||:|||:|||:||:|||.:.||..:..: ::||:.|::|||.||||||.||:..|||||
Zfish  1138 IKR-YGWKKQYVVVSSKKILFYNDEQDKEQSNPS-MVLDIDKLFHVRPVTQGDVYRAETDEIPRI 1200

  Fly  1213 FQLLYAGEGASHRPDEQSQLDV-SVLHG---NCNEERPGTIVHKGHEFVHITYHMPTACEVCPKP 1273
            ||:|||.||...:     :.|| ||..|   ||       :.||||||:...||.||.||.|.||
Zfish  1201 FQILYANEGECRK-----ETDVESVPQGDKANC-------LPHKGHEFIPTLYHFPTNCEACSKP 1253

  Fly  1274 LWHMFKPPAAYECKRCRNKIHKEHVD-KHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWVARLL 1337
            |||:||||.|.||:||..|.||:|:| |.|.:.|||:|:|..|||||||||.:.::|..|:..|.
Zfish  1254 LWHVFKPPPALECRRCHVKCHKDHLDKKEDMITPCKVNYDVTSARDMLLLALSQDEQKKWIGHLG 1318

  Fly  1338 KRIQKSGYKAASYNNNSTDGSKISPSQSTRSSYKPYAVNVQRSATLPANSSLK 1390
            |:|.|:                 .||...|.|  |.:::|:..    ||.|.:
Zfish  1319 KKIPKT-----------------PPSTFARQS--PRSMSVRSG----ANQSFR 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rok	NP_536796.2	STKc_ROCK	61..411	CDD:270747	240/349 (69%)
		S_TKc	87..349	CDD:214567	190/261 (73%)
		SbcC	484..1088	CDD:223496	201/640 (31%)
		Rho_Binding	963..1027	CDD:286056	24/67 (36%)
		PH_ROCK	1134..1250	CDD:269948	58/119 (49%)
		C1	1254..1307	CDD:197519	31/53 (58%)
rock1	XP_021334267.1	STKc_ROCK1	4..408	CDD:270772	258/395 (65%)
		SMC_N	<426..1105	CDD:330553	216/715 (30%)
		PH_ROCK	1124..1230	CDD:269948	58/119 (49%)
		C1	1234..1288	CDD:237996	31/53 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575973
Domainoid	1	1.000	410	1.000	Domainoid score	I657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1085	1.000	Inparanoid score	I236
OMA	1	1.010	-	-		QHG46537
OrthoDB	1	1.010	-	-		D36370at33208
OrthoFinder	1	1.000	-	-		FOG0001986
OrthoInspector	1	1.000	-	-		otm24453
orthoMCL	1	0.900	-	-		OOG6_104177
Panther	1	1.100	-	-	LDO	PTHR22988
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2768
SonicParanoid	1	1.000	-	-		X1475
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940