DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and NHO1

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_178161.1	Gene:	NHO1 / 844385	AraportID:	AT1G80460	Length:	522	Species:	Arabidopsis thaliana

Alignment Length:	517	Identity:	249/517 - (48%)
Similarity:	343/517 - (66%)	Gaps:	21/517 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKKLV 83
            |:|:||:||||.||||:.... ..|..||:|....:.:.||.|.|||.|:.:|..||..|..|..
plant     7 FIGSIDQGTTSTRFIIYDHDA-RPVASHQVEFTQFYPEAGWVEHDPMEILESVKVCIAKALDKAT 70

  Fly    84 AVGGKVE-EIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINYL 147
            |.|..|: .:..||:|:|||:||||.:::|.||..||:|:|.||:|....|.:.:....   ::.
plant    71 ADGHNVDGGLKAIGLTDQRETTVVWSKSTGLPLHKAIVWMDARTSSICRRLEKELSGGR---SHF 132

  Fly   148 RPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTNA 212
            ...||||:|.|||.:||.||.:||..|..|::||.|:||||||||::|:|||.:.|:|.||||||
plant   133 VESCGLPISTYFSAMKLLWLMENVDDVKDAIKKGDAIFGTIDTWLIWNMTGGINGGLHVTDVTNA 197

  Fly   213 SRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQG-VLQGIGITSVLGDQQAALVG 276
            |||||||::||.||.:.||..|:|..|||:|.|:||..|.|.:| .:.||.|...||||.||::|
plant   198 SRTMLMNLKTLSWDQDTLKTLGIPAEILPKIVSNSEVIGEICKGWPIPGIKIAGCLGDQHAAMLG 262

  Fly   277 QQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNW 341
            |.| .||:||:|||||.|:|.|||...:.|.||||||:.|:||.:|...||||||::|||||..|
plant   263 QAC-RKGEAKSTYGTGAFILLNTGEVPIKSGHGLLTTLAYKLGPQAQTNYALEGSIAIAGAAVQW 326

  Fly   342 LRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRAT 406
            |||::.:|:::.:||.:|:.||::..||||||||||:||:|.:|||||..|::..|...||.||.
plant   327 LRDSLGIIKSASEIEDLAAMVDSTGGVYFVPAFNGLFAPWWREDARGVCIGITRFTNKSHIARAV 391

  Fly   407 LEAVCFQVRDILDSMHKDC----KIPLAK----LMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAE 463
            ||::||||:|:||||:||.    .:...|    |.||||.|.|||.:|:|:||:|..|:|....|
plant   392 LESMCFQVKDVLDSMNKDAGEKGSLNNGKGEFLLRVDGGATANNLLMQIQADLMGSPVVRPVDIE 456

  Fly   464 TTALGAAMAAYKAVENRYQMEAPLSKSGPR----EAIKPSISATDRNLRYQKWKMAIDRSLN 521
            |||||||.||..||  .:..||.:.:||.:    :..:|::....|..:...|..|::|:.:
plant   457 TTALGAAYAAGLAV--GFWKEADIFESGEKAKNSKVFRPAMEEGIRKKKVASWCKAVERTFD 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	249/517 (48%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	249/517 (48%)
NHO1	NP_178161.1	PLN02295	7..522	CDD:215166	249/517 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	238	1.000	Domainoid score	I602
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134743
Inparanoid	1	1.050	462	1.000	Inparanoid score	I364
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D519426at2759
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm2554
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840