DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and Gk

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_008771496.1	Gene:	Gk / 79223	RGDID:	70893	Length:	587	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	281/556 - (50%)
Similarity:	368/556 - (66%)	Gaps:	41/556 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKK 81
            ||.|||:|:||:|.||::|.:.|.|::..||:|::..|.:|||.||||..|:.:|.|||...|:|
  Rat    10 GPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEK 74

  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAI--------------------------- 119
            |..:...:..|..||::||||:|||||:.:|:||.||:
  Rat    75 LGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVAAPVSPGSSVPVAVVPSGSPVPAAGAS 139

  Fly   120 -IWLDNRTTSTVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTA 183
             :|||.||.||||:|.:.||.|.   |:::...|||||.|||.||||||.|||..|.:|:|:..|
  Rat   140 SVWLDLRTQSTVEKLSKRIPGNN---NFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRA 201

  Fly   184 MFGTIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSE 248
            :|||||:||:::||||.:.|||.|||||||||||.||.:|:||..|.:|||:|..|||.:.||||
  Rat   202 LFGTIDSWLIWSLTGGINGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSE 266

  Fly   249 FYG------SIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHST 307
            .||      |:..|.|:|:.|:..||||.||||||.|...||||.|||||||||.|||...|.|.
  Rat   267 IYGLMKISHSLKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSE 331

  Fly   308 HGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVP 372
            |||||||.|:|||....:|||||||:||||...|||||:.:|::|.:||.:|..|..|...||||
  Rat   332 HGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVP 396

  Fly   373 AFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGG 437
            ||:|||||||...|||:||||::.|...||..|.|||||||.|:|||:|::||.|||:.|.||||
  Rat   397 AFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGG 461

  Fly   438 MTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAVE--NRYQMEAPLSKSGPREAIKPSI 500
            ||.|.:.:|||:|::.|.|::..:.||||||||||| .|.|  ..:.:|.....:...|..:|.|
  Rat   462 MTSNKILMQLQADILYIPVVKPSMPETTALGAAMAA-GAAEGVGVWSLEPEDLSAVTMERFEPQI 525

  Fly   501 SATDRNLRYQKWKMAIDRSLNWETSTLPQ-GEREAF 535
            :|.:..:||..||.|:.:|:.|.|:..|: |:...|
  Rat   526 NAEESEIRYSTWKKAVMKSIGWVTTQSPESGDPSIF 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	275/539 (51%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	275/539 (51%)
Gk	XP_008771496.1	glycerol_kin	11..547	CDD:273549	275/539 (51%)
Gk	XP_008771496.1	FGGY_GK1-3_metazoa	11..547	CDD:212664	275/539 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337238
Domainoid	1	1.000	292	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134743
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm44909
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810