DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and CG11594

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	130/569 - (22%)
Similarity:	216/569 - (37%)	Gaps:	118/569 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACK 80
            ||||...:|.||.|||..:       :.|..::..:::...:.| ..:|.....:.:......|:
  Fly     3 SGPFFVGVDVGTGSARAAL-------VACDGRVLEQAVQTIQTW-NPEPGYYNQSSDNIWQSICQ 59

  Fly    81 KLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLV---------NAIIWLDNRTTSTVEELLET 136
            .:..|.|.|::....||......::|.....|.||.         |.|:|:|:|.....:|:
  Fly    60 VVKKVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEI--- 121

  Fly   137 IPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNL----- 196
               ||...:.|:.:.| .:|......||.||:.|   :||.       ||.|  |.:::|
  Fly   122 ---NAFKHSLLKYVGG-QVSLEMEVPKLLWLKRN---LSQT-------FGNI--WRVFDLPDFLT 170

  Fly   197 --TGGKD----CGV---HKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSS-EFYG 251
              ..|.|    |.|   ...|..|.|           |:...||     :..|.|:..:: |..|
  Fly   171 WRATGVDTRSLCSVVCKWNYDAANGS-----------WNKEFLK-----QADLEELTQNNFEKLG 219

  Fly   252 SIAQ--GVLQGIGITSVLGDQ---QAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLL 311
            |..|  |...|.|:|:....:   .|..|....|....|.|....||....:.|...|.....|:
  Fly   220 SDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGCRSKESKGADDVQGKMALI 284

  Fly   312 ---TTVGYQLGRKA--------------VPFYAL-EGSVSIAGAAFN------------------ 340
               :|....:.|||              :|.|.| ||..||||...:
  Fly   285 AGTSTCHMSITRKACFAQGVWGPYQDAIIPGYFLNEGGQSIAGHLLDHVLKSHESYAELKSQLGE 349

  Fly   341 --WLRDNMN-LIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHI 402
              ::..::| |:........::.....:.||:..|..:|..:|..:...||||.||.....:|.:
  Fly   350 DKFIYQHLNKLLPELAAARGLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESL 414

  Fly   403 V---RATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAET 464
            .   .|.::|:.:..|.|::::::..:.|...|:..||:..|.|::|..:|:..:..|.....|.
  Fly   415 AIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEM 479

  Fly   465 TALGAAMAAYKAVENRYQMEAPLSKS--GPREAIKPSISATD-RNLRYQ 510
            ..:||| |...|....:......|||  |..:.:||:....: .|.:|:
  Fly   480 VLVGAA-ALGAAASGHFDSLESASKSMGGTGQLVKPNAETLEFHNRKYK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	128/567 (23%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	128/567 (23%)
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	128/567 (23%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	127/566 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443084
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740