DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and Gk2

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001286904.1	Gene:	Gk2 / 38221	FlyBaseID:	FBgn0035266	Length:	576	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	237/514 - (46%)
Similarity:	341/514 - (66%)	Gaps:	24/514 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 VGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKKLVA 84
            ||.|||||.:..|.|:.....:.:..|::|:..|..::||.||||:.::.::|:|...|.|:|..
  Fly    33 VGVIDEGTKTIGFSIYTTPDFKEIAAHRVELSVITPQDGWYEQDPLEMMASINKCAEEAIKQLPE 97

  Fly    85 VGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINYLRP 149
            .|....:|:|:|||||||:|:|||..:|:||.||::|.|.||::|||:::..:    ::.|:.|.
  Fly    98 QGFSASDIVTVGITNQRETTIVWDAVTGKPLYNALLWKDIRTSTTVEQIVAKV----QDPNHFRS 158

  Fly   150 LCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTNASR 214
            ..|||:|.|||.:|:||||||||.|.||:.:.....||:|:|:::|||.|   .:|.||||||||
  Fly   159 STGLPISTYFSALKIRWLRDNVPEVRQAIRERRCKAGTVDSWIVWNLTNG---ALHITDVTNASR 220

  Fly   215 TMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIA--QGVLQGIGITSVLGDQQAALVGQ 277
            |:|||:||..||..|||.||:.:.:||.|.|.||.:|.|.  :..|:|:.::.::|:|||:|:||
  Fly   221 TLLMNLETQAWDPVLLKTFGIREEMLPTIHSCSEIFGKITSERSPLRGMTLSGIMGNQQASLLGQ 285

  Fly   278 QCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWL 342
            .|:..||.|.||.:|||||.|||...|.|.|||||||.|:||.:|...||:||:||:||.|.:||
  Fly   286 MCVKPGQTKNTYRSGCFLLCNTGDKPVFSRHGLLTTVAYKLGPQAPTIYAIEGAVSVAGHALSWL 350

  Fly   343 RDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRATL 407
            ::.:.::.:|...|..|..|..|.||||||||.|||||||.|:|||:|.||::.|...|||||.|
  Fly   351 QNKVRILPDSRDAEKYAEMVPTSGDVYFVPAFTGLYAPYWRQNARGIIIGLTQFTRKNHIVRAAL 415

  Fly   408 EAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMA 472
            |::|||.||||:.||::|...:.||..||.:|.|||.:|||:|.:|:.|.|:::.::||.||||.
  Fly   416 ESICFQTRDILECMHQECGYEINKLHADGKLTTNNLLMQLQADTIGMPVFRSQLMDSTAFGAAMC 480

  Fly   473 AYKA---------VENRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNW 522
            |.:|         .|.||.      ::...:....:.:..:|..||.|||.|::|||.|
  Fly   481 AAQADGVNLCQFEPEKRYY------ENVHYDTFLATTTDVERKERYGKWKRAVERSLGW 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	236/512 (46%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	236/512 (46%)
Gk2	NP_001286904.1	glycerol_kin	31..533	CDD:273549	236/512 (46%)
Gk2	NP_001286904.1	FGGY_GK1-3_metazoa	31..533	CDD:212664	236/512 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443069
Domainoid	1	1.000	163	1.000	Domainoid score	I2404
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	429	1.000	Inparanoid score	I967
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18729at7147
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm51314
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	P	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
	11	10.800