DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk1 and Atad2b

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001349278.1	Gene:	Atad2b / 320817	MGIID:	2444798	Length:	1457	Species:	Mus musculus

Alignment Length:	446	Identity:	85/446 - (19%)
Similarity:	147/446 - (32%)	Gaps:	156/446 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TTSTVEELLETIPNNARNINYLRPLCGLPLS----PYFSGVKLRWLRDNVPVVSQAMEKGTAMFG 186
            |||:.||..|.  ..::::...|..| ||::    ...||:    ||:.|.|.:...:....
Mouse   336 TTSSDEERFER--RKSKSMARARNRC-LPMNFRAEDLASGI----LRERVKVGASLADVDPM--- 390

  Fly   187 TIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSE--- 248
            .||..:.::..||....:|      |.:.|::              |.|   :.|||....:
Mouse   391 NIDKSVRFDSIGGLSHHIH------ALKEMVV--------------FPL---LYPEIFEKFKIQP 432

  Fly   249 -----FYGSIAQG---VLQGIGITSVLGDQQAALV---GQQCLAK--GQAKATYGTGCFLLYNTG 300
                 |||....|   |.:.:......||::.|..   |..||:|  |:::..........|...
Mouse   433 PRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWVGESERQLRLLFDQAYLMR 497

  Fly   301 PSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDN--------MNLIQNSGQIET 357
            |||:.                   |..::|...:..:..:.:..:        |:.:.|.|:|..
Mouse   498 PSIIF-------------------FDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDNRGEIVV 543

  Fly   358 MASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVR------------------ 404
            :.:|  |.|| ...||   |..|  .:..|..:..|.::...:||::
Mouse   544 IGAT--NRLD-SIDPA---LRRP--GRFDREFLFNLPDQRARKHILQIHTRDWNPKLSDAFLGEL 600

  Fly   405 ---------ATLEAVCFQVR---------DILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDL 451
                     |.::|:|.:..         .|..|.||                       ||.|:
Mouse   601 AEKCVGYCGADIKALCTEAALTALRRRYPQIYASSHK-----------------------LQLDV 642

  Fly   452 VGIQVLRAKIAETTALGAAMAAYKAVENRYQMEAPLSKSGPREAIKPSISATDRNL 507
            ..| ||.|............|:.:||.:..|..:|:        |:|.:..:..|:
Mouse   643 TSI-VLSAHDFYHAMQNIVPASQRAVMSSGQALSPI--------IRPLLERSFNNI 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	85/446 (19%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	85/446 (19%)
Atad2b	NP_001349278.1	TIP49	<396..>668	CDD:332389	61/345 (18%)
Atad2b	NP_001349278.1	Bromo_AAA	959..1070	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900