DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and Gykl1

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_599168.1	Gene:	Gykl1 / 291468	RGDID:	1305596	Length:	549	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	276/520 - (53%)
Similarity:	363/520 - (69%)	Gaps:	4/520 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTLSGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECIT 76
            |..:.||.|||:|:||:|.||::|...|.|::|.||:|:...|.:|||.||||..|:.:|.|||.
  Rat     5 PKAVLGPLVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPREGWVEQDPKVILQSVYECIE 69

  Fly    77 GACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNA 141
            ..|:||......:..|..||:|||||:|:|||:.:|:||.||::|||.||.||||.|.::|  :|
  Rat    70 KTCEKLGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLNKSI--SA 132

  Fly   142 RNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHK 206
            .| |:::...|||:|.|||.|||.||.:||..|.:|:|.|.|.|||:|:||::.:|||.:.|||.
  Rat   133 SN-NFIKIKTGLPISTYFSAVKLHWLIENVKNVQKAIEDGRAFFGTVDSWLIWCMTGGINGGVHC 196

  Fly   207 TDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQ 271
            |||:|||||||.||.:||||..|.:|||:|.||||.|.||||.||.:..|||:|:.|:..||||.
  Rat   197 TDVSNASRTMLFNIHSLQWDEELCEFFGIPMTILPRIRSSSEIYGLMKSGVLEGVPISGCLGDQS 261

  Fly   272 AALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAG 336
            ||||||.||..||||:|||||||||.|||...|:|.|||||||.|::||:...:|||||||:|||
  Rat   262 AALVGQLCLQDGQAKSTYGTGCFLLCNTGQKCVNSDHGLLTTVAYKMGREEPVYYALEGSVAIAG 326

  Fly   337 AAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEH 401
            |..:||::|:.:|::|..||.:|.....|...||||||:|||||||:..|||:||||::.|...|
  Rat   327 AVVSWLKNNLQIIKSSSDIEKLAEKAGTSYGCYFVPAFSGLYAPYWDPSARGIICGLTQFTNKFH 391

  Fly   402 IVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTA 466
            |..|.|||||||.|:|||:|:.||.|||..|.||||||.|.:.:|||:|::.|.|::..:.||||
  Rat   392 IAFAALEAVCFQTREILDAMNSDCGIPLTHLQVDGGMTANKILMQLQADILCIPVMKPFMPETTA 456

  Fly   467 LGAAMAAYKAVENRYQMEAPLSKSGPR-EAIKPSISATDRNLRYQKWKMAIDRSLNWETSTLPQG 530
            |||||||..|...|.....|...:|.: |..:|.|:..:...||..||.|:.:|:.|..:..|.|
  Rat   457 LGAAMAAGAAEGIRVWSLDPKDLTGVQMEKFEPQINVEESEGRYSTWKRAVMKSMGWVLTQSPDG 521

Fly 531 530
Rat 522 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	271/504 (54%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	271/504 (54%)
Gykl1	NP_599168.1	glycerol_kin	11..513	CDD:273549	271/504 (54%)
Gykl1	NP_599168.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	271/504 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337239
Domainoid	1	1.000	292	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	559	1.000	Inparanoid score	I1059
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm44909
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770