DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk1 and ATAD2

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_054828.2	Gene:	ATAD2 / 29028	HGNCID:	30123	Length:	1390	Species:	Homo sapiens

Alignment Length:	343	Identity:	67/343 - (19%)
Similarity:	118/343 - (34%)	Gaps:	98/343 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 LMNIETLQWDANL--------------LKFFGLPKTILPEICSSSE--------FYGSIAQG--- 256
            |.:::.:|.|:::              ||...:...:.||:....:        |||....|
Human   411 LADVDPMQLDSSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTL 475

  Fly   257 VLQGIGITSVLGDQQAALV---GQQCLAK--GQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGY 316
            |.:.:......||::.|..   |..||:|  |:::...                   .||....|
Human   476 VARALANECSQGDKRVAFFMRKGADCLSKWVGESERQL-------------------RLLFDQAY 521

  Fly   317 QLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPY 381
            |:....:.|..::|...:..:.    :|.:    :|..:.|:.:.:|            ||
Human   522 QMRPSIIFFDEIDGLAPVRSSR----QDQI----HSSIVSTLLALMD------------GL---- 562

  Fly   382 WNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSM-HKDCKIPLAKLMV-DGGMTVNNLF 444
               |:||.|..:......:.|..|......|. |:.|.|: .|:.:..:.|:.. |......:.|
Human   563 ---DSRGEIVVIGATNRLDSIDPALRRPGRFD-REFLFSLPDKEARKEILKIHTRDWNPKPLDTF 623

  Fly   445 L-QLQSDLVGIQVLRAKIAETTALGA------AMAAYKAVENRYQMEAPLSKSGPREAIKPSISA 502
            | :|..:.||.            .||      |.||..|:..||......|:....:....:|||
Human   624 LEELAENCVGY------------CGADIKSICAEAALCALRRRYPQIYTTSEKLQLDLSSINISA 676

  Fly   503 TDRNLRYQKWKMAIDRSL 520
            .|..:..||...|..|::
Human   677 KDFEVAMQKMIPASQRAV 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	67/343 (20%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	67/343 (20%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..380
		AAA	459..600	CDD:214640	35/187 (19%)
		AAA	464..598	CDD:278434	34/180 (19%)
		COG5076	<915..1153	CDD:227408
		Bromo_AAA	987..1097	CDD:99957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900