DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and Shpk

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001028854.1	Gene:	Shpk / 287479	RGDID:	1308004	Length:	472	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	111/529 - (20%)
Similarity:	191/529 - (36%)	Gaps:	142/529 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQI---------EVESIFQKEGWCEQDPMAIVNTV 71
            |.|....||.||||.:..:..|.......|..:         |.||........|||...|:..:
  Rat     3 SRPVTLGIDLGTTSVKAALLEAAPGHPSGFVVLASCARAAGAETESAAAGPQGREQDVTRIIQAL 67

  Fly    72 NECITGACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSG--------------QPLVNAIIWL 122
            |||:.....:      :::.:..||::.|....:.|....|              :.:.:.:.|.
  Rat    68 NECLDALPPR------QLQRVGAIGVSGQMHGILFWKTGQGCEWTERGSAPVFEPRAVSHLVTWQ 126

  Fly   123 DNRTTSTVEELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGT 187
            |||..|   ..|.::|         :|...|.::..|....:.||..|.|...::.:    :.||
  Rat   127 DNRCNS---GFLASLP---------KPASHLSVATGFGCATIFWLLKNSPEFLKSYD----VAGT 175

  Fly   188 IDTWLMYNLTGGKDCGVHKTDVT--NASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFY 250
            |..:::..|     ||:.:..::  ||:.....|.::..|::::|:..|.|..:||:|.......
  Rat   176 IQDYVVAML-----CGLPRPLMSDQNAASWGYFNTQSQSWNSDILQMAGFPTHLLPDIAEPGSLA 235

  Fly   251 G-------SIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTH 308
            |       .|..|...|:    .|||.||::  ..|:  ||.     |...|..:|...:..|
  Rat   236 GRTSHTWFEIPAGTEVGV----ALGDLQASV--YSCM--GQR-----TDAVLNISTSVQLAAS-- 285

  Fly   309 GLLTTVGYQLGRKAVP-----FYA------LEGSVSIAG----AAF-----NWLRD-NMNLIQN- 351
               ..||:|..:...|     |:.      |..:.|:.|    |.|     .|:.| .:.:.::
  Rat   286 ---MPVGFQPPQTPDPAAPVAFFPYFDRTYLGVAASLNGGNVLATFVHMLVQWMTDLGLEVEEST 347

  Fly   352 --SGQIETMASTVDNSLDVYFVPAFNG-LYAPYWNQDARGVICGLSEETTS-EHIVRATLEAVCF 412
              |..|:..|...|..|.:  .|...| .:.|    |....:..:|....| .|:.|    |:|
  Rat   348 VYSRMIQAAAQQKDTHLTI--TPTVLGERHLP----DQLASVTRISSSDLSLGHVTR----ALC- 401

  Fly   413 QVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAV 477
              |.|:.::|.  .:|               |.|||.  .|::       .....|:|::..:.:
  Rat   402 --RGIVQNLHS--MLP---------------FQQLQE--WGVE-------RVVGSGSALSRNEVL 438

  Fly   478 ENRYQMEAP 486
            :...|...|
  Rat   439 KQEVQRAFP 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	110/527 (21%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	110/527 (21%)
Shpk	NP_001028854.1	FGGY_SHK_like	5..466	CDD:212661	110/527 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810