Protein Alignment Gk1 and GK5

DIOPT Version :9

• Sequence 1: NP_524655.1
• Gene: Gk1 / 43913
• FlyBaseID: FBgn0025592
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_001034636.1
• Gene: GK5 / 256356
• HGNCID: 28635
• Length: 529
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 160/541 - (29%)
• Similarity: 271/541 - (50%)
• Gaps: 40/541 - (7%)

  Fly     9 TPPPPTLSGP----FVGAIDEGTTSARFIIF-RAGTDEIVCFHQIE-VESIFQKEGWCEQDP--- 64
            |.|......|    ||..:|.|::..|..:: ||..   ||...:: ||:::.:.||.|.||
Human     6 TDPEQRAQEPRYPGFVLGLDVGSSVIRCHVYDRAAR---VCGSSVQKVENLYPQIGWVEIDPDVL 67

  Fly    65 -MAIVNTVNECITGACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTS 128
             :..|..:.|.:.       |.|.::.:|:.:||:.||.:.:.|::.:|....|.|.|.|.|...
Human    68 WIQFVAVIKEAVK-------AAGIQMNQIVGLGISTQRATFITWNKKTGNHFHNFISWQDLRAVE 125

  Fly   129 TVEE-----LLETIPNNARNINYLRPLCGLPLSPYF------SGVKLRWLRDNVPVVSQAMEKGT 182
            .|:.     |::...::.|.:::......|..:..|      :.::|.|:..|:..|.:|:|:..
Human   126 LVKSWNNSLLMKIFHSSCRVLHFFTRSKRLFTASLFTFTTQQTSLRLVWILQNLTEVQKAVEEEN 190

  Fly   183 AMFGTIDTWLMYNLTGGKDCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSS 247
            ..||||||||:|.||.|   .|:.||.:|||.|.|.:...:.|...:.....:|.::||.:..:|
Human   191 CCFGTIDTWLLYKLTKG---SVYATDFSNASTTGLFDPYKMCWSGMITSLISIPLSLLPPVRDTS 252

  Fly   248 EFYGSIAQGVL-QGIGITSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLL 311
            ..:||:.:.:. ..|.|.:::.|||:|:.|:.|...|..|.|.|||.||..|||.|:..:|.|..
Human   253 HNFGSVDEEIFGVPIPIVALVADQQSAMFGECCFQTGDVKLTMGTGTFLDINTGNSLQQTTGGFY 317

  Fly   312 TTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNG 376
            ..:|:::|::.|  ...|.:....|.|..|.: .::|..::.:.|.||.::::|..|.|||:|:|
Human   318 PLIGWKIGQEVV--CLAESNAGDTGTAIKWAQ-QLDLFTDAAETEKMAKSLEDSEGVCFVPSFSG 379

  Fly   377 LYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVN 441
            |.||..:..|.....||...|:..|:|||.||::.|:.:.:.:.|.|:..||:.|:..|||:..|
Human   380 LQAPLNDPWACASFMGLKPSTSKYHLVRAILESIAFRNKQLYEMMKKEIHIPVRKIRADGGVCKN 444

  Fly   442 NLFLQLQSDLVGIQVLRAKIAETTALGAAMAAYKAVENRYQMEAPLSKSGPREAI-KPSISATDR 505
            ...:|:.|||:...:.|....:.:.||||..|..|| ..:..:..|.|....|.: ||.....:.
Human   445 GFVMQMTSDLINENIDRPADIDMSCLGAASLAGLAV-GFWTDKEELKKLRQSEVVFKPQKKCQEY 508

  Fly   506 NLRYQKWKMAIDRSLNWETST 526
            .:..:.|..|:.||:||...|
Human   509 EMSLENWAKAVKRSMNWYNKT 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	155/526 (29%)
		FGGY_GK1-3_metazoa	18..522	CDD:212664	155/526 (29%)
GK5	NP_001034636.1	GlpK	19..525	CDD:223628	154/522 (30%)
		FGGY_GK5_metazoa	20..522	CDD:212665	152/518 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820