DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and Gk2

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_034424.1	Gene:	Gk2 / 14626	MGIID:	1329027	Length:	554	Species:	Mus musculus

Alignment Length:	525	Identity:	280/525 - (53%)
Similarity:	368/525 - (70%)	Gaps:	7/525 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TLSGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGA 78
            |.:||.|||:.:||.|.||::|.:.|.|:||.||:|:...:.||||.||||..|:.:|.|||..|
Mouse     7 TSAGPLVGAVVQGTNSTRFLVFNSKTAELVCSHQVELTQEYPKEGWVEQDPKEILKSVYECIAKA 71

  Fly    79 CKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARN 143
            |:||..|...:..|..||::||||:|||||:.:|.||.||::|||.||.||||.|.:.||.|:
Mouse    72 CEKLAEVNIDISNIKAIGVSNQRETTVVWDKFTGDPLYNAVVWLDLRTQSTVETLTKKIPGNS-- 134

  Fly   144 INYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTD 208
             |:::...|||||.|||.|||||:.||:..:.:|:|:|.|||||||:||::.:|||.:.|:|.||
Mouse   135 -NFVKSKTGLPLSTYFSAVKLRWMLDNLRPIQKAVEEGRAMFGTIDSWLIWCMTGGVNGGIHCTD 198

  Fly   209 VTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQAA 273
            ||||.||||.||.:|:||.:|..||.:|.:|||.:|||||.||.:..|.|:|:.|:..||||.||
Mouse   199 VTNACRTMLFNIHSLEWDKDLCDFFEIPMSILPNVCSSSEIYGLMTSGALEGVPISGCLGDQSAA 263

  Fly   274 LVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAGAA 338
            ||||.|..:||||.|||||||||.|||...|.|.||||||:.|:||:....||||||||:||||.
Mouse   264 LVGQMCFHEGQAKNTYGTGCFLLCNTGQKCVFSEHGLLTTLAYKLGKNKPVFYALEGSVAIAGAV 328

  Fly   339 FNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIV 403
            ..|||||..:|..||::|.:|..|..|...||||||:|||||||...|||:||||::.|...||.
Mouse   329 IRWLRDNFEIITTSGEVENLAREVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIA 393

  Fly   404 RATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTALG 468
            .|.|||||||.|:|||:|::||.|||:.|.||||||.|.:.:|||:|::.|.|:::.:.||||||
Mouse   394 FAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNRILMQLQADILHIPVVKSVMPETTALG 458

  Fly   469 AAMAAYKAVE--NRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNWETSTLPQ-G 530
            ||||| .|.|  |.:.:|.....:...|..:|.|.||:..:|:..||.|:.:|:.|.|:..|: |
Mouse   459 AAMAA-GAAEGVNVWSLEPEDLSTILMERYEPQIQATESEIRFSTWKRAVMKSMGWVTAKDPENG 522

  Fly   531 EREAF 535
            :...|
Mouse   523 DNPVF 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	273/505 (54%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	273/505 (54%)
Gk2	NP_034424.1	glycerol_kin	11..513	CDD:273549	273/505 (54%)
Gk2	NP_034424.1	FGGY_GK1-3_metazoa	11..513	CDD:212664	273/505 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833653
Domainoid	1	1.000	292	1.000	Domainoid score	I1512
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1070
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm42844
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760