DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk1 and Gykl1

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_034423.2	Gene:	Gykl1 / 14625	MGIID:	891990	Length:	549	Species:	Mus musculus

Alignment Length:	521	Identity:	278/521 - (53%)
Similarity:	365/521 - (70%)	Gaps:	6/521 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PPTLSGPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECIT 76
            |..:.||.|||:|:||:|.||::|...|.|::|.||:|:...|.||||.||||.||:.:|.|||.
Mouse     5 PKAVLGPLVGAVDQGTSSTRFLVFNPQTAELLCHHQVEIAQEFPKEGWVEQDPKAILQSVYECIE 69

  Fly    77 GACKKLVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNA 141
            .||:||......:..|..||:|||||:|:|||:.:|:||.||::|||.||.||||.|.::|  :.
Mouse    70 KACEKLGQQSIDISNIKAIGVTNQRETTIVWDKFTGEPLYNAVVWLDLRTQSTVENLSKSI--SV 132

  Fly   142 RNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHK 206
            .| |:::...|||:|.|||.|||.||.:||..|.:|:|.|.|:|||:|:||::.:|||.:.|||.
Mouse   133 SN-NFVKNKTGLPISTYFSAVKLHWLIENVRKVQKAIEDGRAIFGTVDSWLIWCMTGGINGGVHC 196

  Fly   207 TDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQGIGITSVLGDQQ 271
            |||:|||||||.||.:||||..|..|||:|.||||.|.||||.||.:..|||:|:.|:..||||.
Mouse   197 TDVSNASRTMLFNIHSLQWDEELCDFFGIPMTILPRIRSSSEIYGLVKSGVLEGVPISGCLGDQS 261

  Fly   272 AALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIAG 336
            ||||||.||..||||:|||||||||.|||...|:|.|||||||.|||||:...:|||||||:|||
Mouse   262 AALVGQLCLQDGQAKSTYGTGCFLLCNTGQKCVNSEHGLLTTVAYQLGRQEPVYYALEGSVAIAG 326

  Fly   337 AAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSEH 401
            |..:|:::|:.:||:|.:||.:|.....|...||||||:|||||||:..|||:||||::.|...|
Mouse   327 AVVSWIKNNLQIIQSSSEIEKLAEVAGTSYGCYFVPAFSGLYAPYWDPSARGIICGLTQFTNKFH 391

  Fly   402 IVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETTA 466
            |..|.|||||||.|:|||:|:.||.|||..|.||||||.|.:.:|||:|::.|.|::..:.||||
Mouse   392 IAFAALEAVCFQTREILDAMNSDCGIPLTHLQVDGGMTANRVLMQLQADILCIPVMKPFMPETTA 456

  Fly   467 LGAAMAAYKAVE--NRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNWETSTLPQ 529
            ||.|||| .|.|  :.:.::.....|...|..:|.|:..:...||..||.|:.:|:.|..:..|.
Mouse   457 LGVAMAA-GAAEGVSVWSLDPKDLSSVQMEKFEPQINVEESEGRYATWKKAVLKSMGWVLTQSPD 520

  Fly   530 G 530
            |
Mouse   521 G 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	273/505 (54%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	273/505 (54%)
Gykl1	NP_034423.2	glycerol_kin	11..513	CDD:273549	273/505 (54%)
Gykl1	NP_034423.2	FGGY_GK1-3_metazoa	11..513	CDD:212664	273/505 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833651
Domainoid	1	1.000	292	1.000	Domainoid score	I1512
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1070
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		otm42844
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770