DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and gk5

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_004917888.1	Gene:	gk5 / 101734558	XenbaseID:	XB-GENE-983229	Length:	561	Species:	Xenopus tropicalis

Alignment Length:	524	Identity:	157/524 - (29%)
Similarity:	266/524 - (50%)	Gaps:	36/524 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AIDEGTTSARFIIF-RAGTDEIVCFHQIEVESIFQKEGWCEQDPMAI----VNTVNECITGACKK 81
            |:|.|::..|..:: :||  :|....:.:::.::.:.|:.|.||.::    |..|.|.|..|
Frog    15 AVDVGSSVLRCHLYNQAG--QICGSAEDKLKVLYPQTGYVEIDPESLWDQFVGIVKEAIKDA--- 74

  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEE-----LLETIPNNA 141
                |.::.::..:||:.||.:.:.|::.:|:|..|.|.|.|.|....|..     ||:.:....
Frog    75 ----GIQMSQVAGLGISTQRATFITWNKTTGEPFHNFISWQDLRAADLVSSWNSSVLLKAVHGVC 135

  Fly   142 RNINYL----RPLCGLPLSPYFSGVKLR--WLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGK 200
            ..:::.    |.|....::.....|.||  |:..|:|.|.|..:.|...||||||||:|.||.|.
Frog   136 TALHFFTRRKRFLAASLINFTTQHVSLRLVWVLQNIPQVRQEAKIGNCCFGTIDTWLLYKLTSGT 200

  Fly   201 DCGVHKTDVTNASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIAQGVLQG--IGI 263
               |..||.:|||.|.:.:...:.|.:.|.....:|.:|.|.:..:|..:| :|..::.|  :.|
Frog   201 ---VFATDYSNASGTAIFDPYLMCWSSFLCSLLSIPMSIFPSVEDTSHNFG-LADPIIFGAAVPI 261

  Fly   264 TSVLGDQQAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYAL 328
            .:::.|||||:.||.|...|..|.|.|||.|:..|||..:..|..||...:|:::|::.|  ...
Frog   262 RALVADQQAAMFGQCCFDVGNVKLTMGTGSFISINTGERLHTSIAGLYPLIGWKIGKEVV--CLA 324

  Fly   329 EGSVSIAGAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGL 393
            ||:.|..|.|..| .:.:||..:....|.||.:|.:...:||||:|:||.||..:..|.....||
Frog   325 EGNASDTGTAIKW-AEELNLFTSVADTEAMARSVPDCGGIYFVPSFSGLQAPVNDPYACASFMGL 388

  Fly   394 SEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLR 458
            ...|:..|:|||.||:|.::.:.:.|::.::..||:..:..|||::.||..:|:.:||:|..:.:
Frog   389 KPSTSKNHLVRAILESVAYRNKQLYDTVLRETTIPITLIRADGGVSNNNFIMQMTADLLGQTIDK 453

  Fly   459 AKIAETTALGAAMAAYKAVENRYQMEAPLSKSGPREA-IKPSISATDRNLRYQKWKMAIDRSLNW 522
            .|..:.::||||..|..|| ..:..:..|.|....:. .:|.....:.......|::|:.|..||
Frog   454 PKHTDMSSLGAAFLAGLAV-GLWSTKDELKKLRTTQCEFEPQAKWKEYEQSMGSWEVALQRCSNW 517

  Fly   523 ETST 526
            ..:|
Frog   518 YNTT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	154/518 (30%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	154/518 (30%)
gk5	XP_004917888.1	FGGY_GK5_metazoa	13..514	CDD:212665	153/515 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010