DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gk1 and atad2b

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_001352895.1	Gene:	atad2b / 100331225	ZFINID:	ZDB-GENE-110411-210	Length:	1402	Species:	Danio rerio

Alignment Length:	407	Identity:	87/407 - (21%)
Similarity:	151/407 - (37%)	Gaps:	100/407 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 TTSTVEELLETIPNNARNINYLRPLCGLPLS----PYFSGVKLRWLRDNVPVVSQAMEKGTAMFG 186
            |:|:.||..|.  ..:::::..|..| ||::    ...|||    |||.|.|.:...:....
Zfish   332 TSSSDEERFER--RKSKSMSRARNRC-LPMNLRAEDLASGV----LRDRVKVGASLADVDPM--- 386

  Fly   187 TIDTWLMYNLTGGKDCGVHKTDVTNASRTML-MNIETLQWDANLLKFFGLPKTILPEICSSSEFY 250
            .:||.:.::..||         :|:..:::. |.:..|.:.....||    |...|..|.   ||
Zfish   387 NLDTSVKFDSVGG---------LTHHIQSLKEMVVFPLLYPQVFEKF----KIQPPRGCL---FY 435

  Fly   251 GSIAQGVLQGIGITSVLGDQQAALVGQQCLAKGQAKATY----GTGCFLLYNTGPSIVHSTHGLL 311
            |.      .|.|.|.|     |..:..:| ::|..|.::    |..|...: .|.|  .....||
Zfish   436 GP------PGTGKTLV-----ARALANEC-SQGDRKVSFFMRKGADCLSKW-VGES--ERQLRLL 485

  Fly   312 TTVGYQLGRKAVPFYALEGSVSIAGAAFNWLRDN--------MNLIQNSGQIETMASTVDNSLDV 368
            ....|.:....:.|..::|...:..:..:.:..:        |:.:.:.|:|..:.:|  |.||
Zfish   486 FDQAYLMRPSIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGAT--NRLD- 547

  Fly   369 YFVPAFNGLYAPYWNQDARGVICGLSEETTSEHIVRATLEAVCFQVRDILDSMHKDCKIPLAKLM 433
            ...||   |..|  .:..|..:..|.::...:|               ||:...:|....||:..
Zfish   548 SIDPA---LRRP--GRFDREFLFNLPDKKARKH---------------ILEIHTRDWSPKLAEPF 592

  Fly   434 VDGGMTVNNLFLQLQSDLVGI--QVLRAKIAETTALGAAMAAYKAV---ENRYQMEAPLSKSGPR 493
            :|          :|....||.  ..::|...| .||.|....|..:   ..|||::......||:
Zfish   593 ID----------ELAERCVGYCGADIKALCTE-AALAALRRRYPQIYGSSQRYQLDVASIVLGPQ 646

  Fly   494 E---AIKPSISATDRNL 507
            :   |::..:.|..|.|
Zfish   647 DFGRALRSIVPAGQRAL 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	87/407 (21%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	87/407 (21%)
atad2b	NP_001352895.1	SpoVK	<341..657	CDD:223540	80/390 (21%)
		P-loop_NTPase	767..879	CDD:328724
		Bromo_AAA	957..1068	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900