DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and zgc:172295

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_009289955.1	Gene:	zgc:172295 / 100136866	ZFINID:	ZDB-GENE-080204-72	Length:	570	Species:	Danio rerio

Alignment Length:	544	Identity:	275/544 - (50%)
Similarity:	358/544 - (65%)	Gaps:	40/544 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKK 81
            ||.|.|||:||:|.||::|.|.|.|::..||:|::..|.||||.|:||..|:.:|.||:...|:|
Zfish    15 GPLVAAIDQGTSSTRFLVFNAKTAELLSHHQVEIKQSFPKEGWVEEDPKEILQSVYECMDRTCEK 79

  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINY 146
            |..:...|..|..:|:|||||:|:|||:.:|:||.|||:|||.||.||||.|:...|  .:|.|:
Zfish    80 LTQLNIDVSNIKAVGVTNQRETTLVWDKQTGEPLYNAIVWLDLRTQSTVERLINKTP--GKNKNH 142

  Fly   147 LRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTN 211
            |:...|||:|.|||.||||||.|||..|.:|:....|||||:|:||::.|||||:.|||.|||||
Zfish   143 LKDKTGLPISTYFSAVKLRWLMDNVEKVHEAVLSHRAMFGTVDSWLIWCLTGGKNGGVHCTDVTN 207

  Fly   212 ASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYG------SIAQGVLQGIGITSVLGDQ 270
            ||||||.||.|:.||..|..:|.:|..|||::.||||.||      .:..|.|.|:.|:..||||
Zfish   208 ASRTMLFNIHTMDWDPELCIYFDIPMGILPKVRSSSEIYGLMKISSKLKSGPLTGVPISGCLGDQ 272

  Fly   271 QAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIA 335
            .||||||.|...||||.|||||||||.|.|...|.|.|||||||.|:|||.....|||||||:||
Zfish   273 SAALVGQMCFKDGQAKNTYGTGCFLLKNVGTKPVMSDHGLLTTVAYKLGRDKPACYALEGSVAIA 337

  Fly   336 GAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSE 400
            ||...||:||:.:||.|.::|.:|:.|..|...||||||:|||||||...|||:||||::.|...
Zfish   338 GAVVRWLKDNLGIIQTSTELEKLAADVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNRS 402

  Fly   401 HIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETT 465
            |:..|.|||||||.|:|||:|::|..|.|::|.||||||.|.|.:|||:|::.|.|::..:.|||
Zfish   403 HLAFAALEAVCFQTREILDAMNQDSGINLSQLQVDGGMTSNRLLMQLQADILCIPVVKPSMPETT 467

  Fly   466 ALGAAMAAYKA---------VENRYQMEAPLSKSGPREAIKPSIS-ATDRNLRYQKWKMAIDRSL 520
            ||||||||..|         .|:..::.:        |..:|.|: ..:..|||.:||.|:.|::
Zfish   468 ALGAAMAAGAAEGVSVWSLNPEDLTEVTS--------EKFEPQINPEAESELRYARWKKAVQRAM 524

  Fly   521 NWET--------------STLPQG 530
            ||||              |::|.|
Zfish   525 NWETIEPVNSGNEDTSIFSSVPLG 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	267/519 (51%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	267/519 (51%)
zgc:172295	XP_009289955.1	glycerol_kin	16..526	CDD:273549	267/519 (51%)
zgc:172295	XP_009289955.1	FGGY_GK1-3_metazoa	16..526	CDD:212664	267/519 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576366
Domainoid	1	1.000	284	1.000	Domainoid score	I1602
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	543	1.000	Inparanoid score	I1135
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		oto39301
orthoMCL	1	0.900	-	-		OOG6_100613
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2135
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800