DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and gk

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_012811696.1	Gene:	gk / 100038285	XenbaseID:	XB-GENE-961541	Length:	562	Species:	Xenopus tropicalis

Alignment Length:	527	Identity:	276/527 - (52%)
Similarity:	360/527 - (68%)	Gaps:	21/527 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GPFVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWCEQDPMAIVNTVNECITGACKK 81
            ||.|||||:||:|.||::|.|.|.|::..||:|::..|.||||.||||..|:.:|.||:...|:|
Frog    10 GPLVGAIDQGTSSTRFLVFNAKTAELLSHHQVEIKQKFPKEGWVEQDPKEILQSVYECVEKTCEK 74

  Fly    82 LVAVGGKVEEIITIGITNQRESTVVWDRNSGQPLVNAIIWLDNRTTSTVEELLETIPNNARNINY 146
            |..:...:..|..||::||||:|||||:.:|:||.||::|||.||.||||.||:.||  .:|.|:
Frog    75 LTQLNIDITNIKAIGVSNQRETTVVWDKTTGEPLYNAVVWLDLRTQSTVERLLKRIP--GKNKNF 137

  Fly   147 LRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNLTGGKDCGVHKTDVTN 211
            .:...|||||.|||.||:|||.|||..:..|:.:|.|||||:|:|::::|||.|:.|||.|||||
Frog   138 FKSRTGLPLSTYFSAVKIRWLLDNVEEIRHAVSEGRAMFGTVDSWIIWSLTGAKNGGVHCTDVTN 202

  Fly   212 ASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYG------SIAQGVLQGIGITSVLGDQ 270
            ||||||.||.||:||..|.:||.:|..:||::.||||.||      |:..|.|.|:.|:..||||
Frog   203 ASRTMLFNIHTLEWDTELCQFFDIPMELLPKVRSSSEIYGLMKICPSLKSGALTGVPISGCLGDQ 267

  Fly   271 QAALVGQQCLAKGQAKATYGTGCFLLYNTGPSIVHSTHGLLTTVGYQLGRKAVPFYALEGSVSIA 335
            .||||||.|...||||.|||||||||.|||...|.|.|||||||.|:|||.....|||||||:||
Frog   268 SAALVGQMCFQDGQAKNTYGTGCFLLCNTGSKPVLSEHGLLTTVAYKLGRDKPACYALEGSVAIA 332

  Fly   336 GAAFNWLRDNMNLIQNSGQIETMASTVDNSLDVYFVPAFNGLYAPYWNQDARGVICGLSEETTSE 400
            ||...|||||:.:::.:.::|.:|:.|..|...||||||:|||||||...|||:||||::.|...
Frog   333 GAVVRWLRDNLGIVKTTEEVEKLAAEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNRN 397

  Fly   401 HIVRATLEAVCFQVRDILDSMHKDCKIPLAKLMVDGGMTVNNLFLQLQSDLVGIQVLRAKIAETT 465
            ||..|.|||||||.|:|||:|:|||.|||.:|.||||||.|.:.:|||:|::.|.|::..:.|||
Frog   398 HIAFAALEAVCFQTREILDAMNKDCGIPLNQLQVDGGMTSNKILMQLQADILCIPVVKPSMPETT 462

  Fly   466 ALGAAMAAYKAVE-------NRYQMEAPLSKSGPREAIKPSISATDRNLRYQKWKMAIDRSLNWE 523
            |||||||| .|.|       |...:.|...     |..:|.|:..:...||.:||.|:.:|:.||
Frog   463 ALGAAMAA-GAAEGVGVWSLNPGDLTAVTC-----ERFEPQINPEESEFRYARWKKAVMKSMGWE 521

  Fly   524 TSTLPQG 530
            ::....|
Frog   522 SAEPTNG 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	272/516 (53%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	272/516 (53%)
gk	XP_012811696.1	FGGY_GK1-3_metazoa	11..520	CDD:212664	272/516 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	291	1.000	Domainoid score	I1514
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1113
OMA	1	1.010	-	-		QHG60628
OrthoDB	1	1.010	-	-		D352321at33208
OrthoFinder	1	1.000	-	-		FOG0001035
OrthoInspector	1	1.000	-	-		oto102956
Panther	1	1.100	-	-	O	PTHR10196
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2135
SonicParanoid	1	1.000	-	-		X1107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110