DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gk1 and shpk

DIOPT Version :9

Sequence 1:	NP_524655.1	Gene:	Gk1 / 43913	FlyBaseID:	FBgn0025592	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_001341627.4	Gene:	shpk / 100001676	ZFINID:	ZDB-GENE-060526-357	Length:	469	Species:	Danio rerio

Alignment Length:	506	Identity:	103/506 - (20%)
Similarity:	185/506 - (36%)	Gaps:	106/506 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 FVGAIDEGTTSARFIIFRAGTDEIVCFHQIEVESIFQKEGWC---EQDPMAIVNTVNECITGACK 80
            ||..:|.||||.:.::..|.:..:.........:........   ||||..|:..:::|:....|
Zfish    11 FVLGMDLGTTSVKVVLLEAQSKTVTESRSFTTNADISSSTHTHAKEQDPALIIAALDQCMAALPK 75

  Fly    81 KLVAVGGKVEEIITIGITNQRESTVVWDRNSG--------------QPLVNAIIWLDNRTTSTVE 131
                  .|::::..||:..|....|:|..|||              :.:...|.|.|.|...
Zfish    76 ------DKLKKVKFIGVCGQMHGIVLWKSNSGCEWQSKDGITRFSPKDVSQLITWQDGRCDF--- 131

  Fly   132 ELLETIPNNARNINYLRPLCGLPLSPYFSGVKLRWLRDNVPVVSQAMEKGTAMFGTIDTWLMYNL 196
            :.|..:|         :|...|.::..|....:.|...:.|    ....|.:..|||..:::..|
Zfish   132 DFLSALP---------KPDSHLSVATGFGCATVFWYMKHRP----EFLSGFSDAGTIQDYVVSML 183

  Fly   197 TGGKDCGVHKTDVT--NASRTMLMNIETLQWDANLLKFFGLPKTILPEICSSSEFYGSIA---QG 256
                 |.:.|..:|  ||:.....|..|.||:.::||..|.|..:||.:..|....|..:   .|
Zfish   184 -----CSLDKCVMTGQNAASWGYFNTATNQWNTHILKDAGFPVHLLPVLVDSGRVAGHTSCEWYG 243

  Fly   257 VLQGIGITSVLGDQQAALVGQQCLA-KGQAKATYGTGCFLLYNTGPSIV-HSTHGLLTTVGYQLG 319
            :.....:.:.|||.|.::  ..|:. :|.|.....|...|.:....... .|:...|:.:.|
Zfish   244 IPAHTAVGAALGDFQCSV--YSCITDRGHAVLNMSTSAQLTFRMPAEFTPTSSPDPLSPIAY--- 303

  Fly   320 RKAVPFYALEGSVSIAGAAFN--------------WLRD-NMNLIQNSGQIETMASTVDNSLDVY 369
               .|::  |||.....|:.|              |::: .:.:.::|               :|
Zfish   304 ---FPYF--EGSYLAVAASLNGGNVMATFVRMLDSWMKEFGLEVSESS---------------IY 348

  Fly   370 FVPAFNGLYAPYWNQDARGVICG----LSEETTSEHIVRATL------EAVCFQVRDILDSMHKD 424
            .....:.|..|..:......:.|    .|...:..||..:.|      .|||..:.:.|.:|...
Zfish   349 SQLIHSALAQPNTDLTVTSTLLGERHAPSSSASVSHISSSNLSLGHVTRAVCRGIIENLATMMPP 413

  Fly   425 CKIPLA--KLMVDGGMTVN-NLFLQLQSDLV-GIQVLRAKIAETTALGAAM 471
            ..:..|  :.::..|..:: |..||.:.:.| ...|:..|..: :|:|.||
Zfish   414 QSLRAAGVRCIIGSGSALSCNAVLQQEVERVFPFPVVYGKDVD-SAVGVAM 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gk1	NP_524655.1	glycerol_kin	18..522	CDD:273549	103/506 (20%)
Gk1	NP_524655.1	FGGY_GK1-3_metazoa	18..522	CDD:212664	103/506 (20%)
shpk	XP_001341627.4	FGGY_SHK_like	11..464	CDD:212661	103/506 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810