DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF1 and Khdrbs3

DIOPT Version :9

Sequence 1:	NP_524654.2	Gene:	SF1 / 43912	FlyBaseID:	FBgn0025571	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_071585.2	Gene:	Khdrbs3 / 64015	RGDID:	620921	Length:	346	Species:	Rattus norvegicus

Alignment Length:	399	Identity:	104/399 - (26%)
Similarity:	158/399 - (39%)	Gaps:	119/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 QEAYLVQFQIEEISRKLRTGDLGITQNPEERSPSPEPIYSSDGKRLNTRE---FRYRKRLEEQRH 365
            :|.||.:...|:                    .|.:|.: :...||..||   |:..:..:|:::
  Rat     2 EEKYLPELMAEK--------------------DSLDPSF-THALRLVNREIEKFQKGEAKDEEKY 45

  Fly   366 QLIVKMQTVNPEFKPPADYKPPVTRVSDKVLIPQEQHPDINFVGLLIGPRGNTLKAMEKDTGAKI 430
            ..:|    :|...|           :..|||||.:|.|..||||.|:|||||:||.::::|..|:
  Rat    46 IDVV----INKNMK-----------LGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKM 95

  Fly   431 IIRGKGSV----KEGKVGRKDGQPLPGE-DEPLHAFIT--APNPEAVRK---AVDKIKDVIRQGI 485
            .|.||||:    ||.:: ||.|:..... ::.||..|.  ||..||..:   |:::||..:
  Rat    96 SILGKGSMRDKAKEEEL-RKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFL---- 155

  Fly   486 EVPEGHNDLRRMQLRELAQLNGTLRENDIQRC-------TCGSTDHKSWQCPDKPIITNTIVCTS 543
             :|:.::::|:.||:||..|||.....|:...       |.|.|         .|.||.
  Rat   156 -IPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKSTLRTRGVT---------TPAITR------ 204

  Fly   544 CGGTGHLTKDCRNKRP-GSGVP-------GMACEDSQAKIDEEYMSLMAE----LGEGPPPPSAS 596
              |.|.:|     .|| ..|||       |:.............::..|.    .|..||||..:
  Rat   205 --GRGGVT-----ARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPT 262

  Fly   597 AKT----DPPASNGPQLHRASYSIFDKKPSQMQAIQSPPSSSSRDHQRDLGGWGAAAHEHGMGME 657
            .:|    |............||..:|..       .|.|:.|..|:. |.|        ||:|.|
  Rat   263 QETYGEYDYDDGYSTAYDDQSYDSYDNS-------YSTPAQSGADYY-DYG--------HGLGEE 311

  Fly   658 HGMGLDQHG 666
               ..|.:|
  Rat   312 ---AYDSYG 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF1	NP_524654.2	MSL5	253..512	CDD:227503	65/220 (30%)
		SF1-HH	274..385	CDD:292892	15/83 (18%)
		SF1_like-KH	392..510	CDD:239088	50/127 (39%)
Khdrbs3	NP_071585.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		57/199 (29%)
		Qua1	4..53	CDD:406639	13/73 (18%)
		KH-I_KHDRBS3	48..160	CDD:411898	45/132 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..268		13/55 (24%)
		Sam68-YY	266..320	CDD:406871	16/71 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810