DRSC/TRiP Functional Genomics Resources

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Protein Alignment SF1 and Khdrbs1

DIOPT Version :10

Sequence 1:NP_524654.2 Gene:SF1 / 43912 FlyBaseID:FBgn0025571 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_035447.3 Gene:Khdrbs1 / 20218 MGIID:893579 Length:443 Species:Mus musculus


Alignment Length:447 Identity:107/447 - (23%)
Similarity:170/447 - (38%) Gaps:120/447 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 DKTFIPGMPT-ILPSTLDPA----QQEAYLVQFQIEEISRKLRTGDLGITQNPEERSPSPEPIYS 343
            |.|.:...|| :||.:...|    .:..||.:...|:.|.     |...|...:..|...|.|..
Mouse    75 DATVVGSAPTPLLPPSATAAVKMEPENKYLPELMAEKDSL-----DPSFTHAMQLLSVEIEKIQK 134

  Fly   344 SDGKRLNTREFRYRKRLEEQRHQLIVKMQTVNPEFKPPADYKPPVTRVSDKVLIPQEQHPDINFV 408
            .:.|:.:...:     |:...|:.:                     ::.::||||.:|:|..|||
Mouse   135 GESKKDDEENY-----LDLFSHKNM---------------------KLKERVLIPVKQYPKFNFV 173

  Fly   409 GLLIGPRGNTLKAMEKDTGAKIIIRGKGSV----KEGKVGRKDGQPLPGE-DEPLHAFITAPNP- 467
            |.::||:|||:|.::::|||||.:.||||:    ||.:: ||.|.|.... :..||.||....| 
Mouse   174 GKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEEL-RKGGDPKYAHLNMDLHVFIEVFGPP 237

  Fly   468 -EA---VRKAVDKIKDVIRQGIEVPEGHNDLRRMQLRELAQLNGTLRENDIQRCTCGSTDHKSWQ 528
             ||   :..|::::|..:     ||:..:|:.:.|..||:.|||.   .:..|....|...:...
Mouse   238 CEAYALMAHAMEEVKKFL-----VPDMMDDICQEQFLELSYLNGV---PEPSRGRGVSVRGRGAA 294

  Fly   529 CPDKPIITNTIVCTSCG----GT---GHLTKDCRNKRPGSGVPGMACEDSQAKIDEEYMSLMAEL 586
            .|..|:.....|....|    ||   |.:|:.....|   ||                       
Mouse   295 PPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTR---GV----------------------- 333

  Fly   587 GEGPPPPSASAKTDPPASNGPQLHRASYSIFDKKPSQMQAIQSPPSSSSRDHQRDLGGWGAAAHE 651
               ||||:......|.|                :.:.:|.|..||:.:...:: |.|.....|.:
Mouse   334 ---PPPPTVRGAPTPRA----------------RTAGIQRIPLPPTPAPETYE-DYGYDDTYAEQ 378

  Fly   652 HGMGMEHGMGLDQ-------HGHGLAAMDHGMSLGMEHAMAAYVPAPPGTQAPPPMP 701
            ...|.|......|       :||| ...|...:.|.:.    :....|..:|||..|
Mouse   379 SYEGYEGYYSQSQGESEYYDYGHG-ELQDSYEAYGQDD----WNGTRPSLKAPPARP 430

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SF1NP_524654.2 MSL5 253..512 CDD:227503 68/242 (28%)
PTZ00368 <519..>568 CDD:173561 12/55 (22%)
Khdrbs1NP_035447.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..94 6/18 (33%)
Involved in homodimerization. /evidence=ECO:0000250|UniProtKB:Q07666 100..260 54/196 (28%)
Qua1 102..153 CDD:465079 12/60 (20%)
KH-I_KHDRBS1 152..257 CDD:411896 40/131 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..317 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 326..345 7/47 (15%)
Interaction with HNRNPA1. /evidence=ECO:0000250|UniProtKB:Q07666 351..443 20/86 (23%)
Sam68-YY 366..415 CDD:465182 11/50 (22%)
Interaction with ZBTB7A. /evidence=ECO:0000250|UniProtKB:Q07666 400..420 5/24 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..443 6/24 (25%)

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