DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SF1 and Qk

DIOPT Version :9

Sequence 1:	NP_524654.2	Gene:	SF1 / 43912	FlyBaseID:	FBgn0025571	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_001152989.1	Gene:	Qk / 19317	MGIID:	97837	Length:	341	Species:	Mus musculus

Alignment Length:	421	Identity:	97/421 - (23%)
Similarity:	162/421 - (38%)	Gaps:	151/421 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 ERSPSPEPIY----SSDGKRLNTRE-----FRYRKRLEEQRHQLIVK---MQTVNPEFKPPADYK 385
            :..|.|.|.|    .:|.|.:::..     |.:.:||.::....:.|   ..|:|...:..:...
Mouse     8 KEKPKPTPDYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRVRKDMYNDTLNGSTEKRSAEL 72

  Fly   386 P----PVTRVSDKVLIPQEQHPDINFVGLLIGPRGNTLKAMEKDTGAKIIIRGKGSVKEGKV--- 443
            |    |:.::.:|:.:|.:::||.||||.::||||.|.|.:|.:||.||::|||||:::.|.
Mouse    73 PDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGCKIMVRGKGSMRDKKKEEQ 137

  Fly   444 --GRKDGQPLPGEDEPLHAFITAPNPE-----AVRKAVDKIKDVIRQGIEVPEGHNDLRRMQLRE 501
              |:.:.:.|   :|.||..||..:.:     .:::||:::|.::   :...||.:.|::|||.|
Mouse   138 NRGKPNWEHL---NEDLHVLITVEDAQNRAEIKLKRAVEEVKKLL---VPAAEGEDSLKKMQLME 196

  Fly   502 LAQLNGTLRENDIQRCTCGSTDHKSWQCPDKPIITNTIVCTSCGGTGHLTKDCRNKRPGSGVPGM 566
            ||.||||.|:.:|:                .|.:..::..|:......:|
Mouse   197 LAILNGTYRDANIK----------------SPALAFSLAATAQAAPRIIT--------------- 230

  Fly   567 ACEDSQAKIDEEYMSLMAELGEGPPP--PSASAKTDPPASNGPQLHRASYSIFDKKPSQMQAIQS 629
                                  ||.|  |.|:.:|..||.                |:.|..|:.
Mouse   231 ----------------------GPAPVLPPAALRTPTPAG----------------PTIMPLIRQ 257

  Fly   630 PPSSSSRDHQRDLGGWGAAAHEHGMGMEHGMGLDQHGHGLAAMDHGMSLGMEHAMAAYVPAPPGT 694
            ..::.                                         |..|..|..||.|  |||.
Mouse   258 IQTAV-----------------------------------------MPNGTPHPTAAIV--PPGP 279

  Fly   695 QAPPPMPPPLMPWMSAPQPPPPATEPLNPPI 725
            :|.....|...|:..|     |||..|..||
Mouse   280 EAGLIYTPYEYPYTLA-----PATSILEYPI 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF1	NP_524654.2	MSL5	253..512	CDD:227503	63/204 (31%)
		SF1-HH	274..385	CDD:292892	12/63 (19%)
		SF1_like-KH	392..510	CDD:239088	48/127 (38%)
Qk	NP_001152989.1	STAR_dimer	10..66	CDD:406848	12/55 (22%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q17339	11..82		14/70 (20%)
		KH-I_Hqk	81..183	CDD:411893	35/107 (33%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000250\|UniProtKB:Q96PU8	182..213		15/46 (33%)
		PHA03247	<211..314	CDD:223021	33/196 (17%)
		SH3-binding	276..279		2/2 (100%)
		Quaking_NLS	312..341	CDD:406855
		Nuclear localization signal	324..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910