DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SF1 and sfa-1

DIOPT Version :9

Sequence 1:	NP_524654.2	Gene:	SF1 / 43912	FlyBaseID:	FBgn0025571	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_503033.1	Gene:	sfa-1 / 178486	WormBaseID:	WBGene00013808	Length:	699	Species:	Caenorhabditis elegans

Alignment Length:	839	Identity:	311/839 - (37%)
Similarity:	404/839 - (48%)	Gaps:	225/839 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SATPPDLLSLAASREVSAAVAVAASANGGSGRSADKERS---RSRDRGRDKDKDRDKDRKKRDKD 63
            :|.||..|          .|...:|.:.|..:|..:..|   |.|||.|.:|:||.|||||
Worm    32 TAAPPPAL----------VVPTISSMSSGDNKSPSRSESVSDRKRDRSRSRDRDRKKDRKK---- 82

  Fly    64 SRDRDSRRRDDRGDRDRDRERDRDSRSHRSKSRNYDDGDRRRKRSRSRDRDRDRKRDRDRDSRSR 128
                          :||.|||||:.||.||:||:            .|||||:|:|.|.|....|
Worm    83 --------------KDRSRERDRERRSSRSRSRS------------PRDRDRERRRRRSRSPPPR 121

  Fly   129 RSSSRGGRDDYDRSRRRRSRSRSYERRRNDRGSQRDQRDQHSQRSSRERTHVNPFDTSNSRNSLN 193
            |.|..||    ||.||.||.....               .:|.:..:|.. :||.
Worm   122 RRSRSGG----DRRRRERSPPSMV---------------PNSPQRVKEPV-INPL---------- 156

  Fly   194 QDHDQSRIPSLFDRQQGLETIREEGREQRFDLTQTIQELMGNAGGNKGFASFFNSQNSNDSTSNG 258
                                |||       ||...::                          :|
Worm   157 --------------------IRE-------DLAAAVE--------------------------SG 168

  Fly   259 AFDNSADSAA------ERKRKRKSRWGGSENDKTFIPGMPTILPSTLDPAQQEAYLVQFQIEEIS 317
            |....|..|.      ..|::|:|||   ...|:|:||||||||:.|...|:.|||:|.:||:.:
Worm   169 AVPVEAVQAGAVVALNPAKKERRSRW---STTKSFVPGMPTILPADLTEDQRNAYLLQLEIEDAT 230

  Fly   318 RKLRTGDLGITQNPEERSPSPEPIYSSDGKRLNTREFRYRKRLEEQRHQLIVKMQTVNPEFKPPA 382
            ||||..|.|:.:. .||||||||:|.::||||||||.|.|:.||:.||:.|..:..:||.|||||
Worm   231 RKLRLADFGVAEG-RERSPSPEPVYDANGKRLNTREVRKRQELEQLRHEKIQALLKINPNFKPPA 294

  Fly   383 DYKPPVTRVSDKVLIPQEQHPDINFVGLLIGPRGNTLKAMEKDTGAKIIIRGKGSVKEGKVGRKD 447
            ||:.|..|:.|||.|||||.||:|||||||||||||||::|.:||||||||||||:||||:..:.
Worm   295 DYRAPNIRLHDKVWIPQEQFPDLNFVGLLIGPRGNTLKSLEAETGAKIIIRGKGSIKEGKLTNRL 359

  Fly   448 GQPLPGEDEPLHAFITAPNPEAVRKAVDKIKDVIRQGIEVPEGHNDLRRMQLRELAQLNGTLREN 512
            | |:|||:|||||::|..:...::||.:|||.||.:...:|: :|:||::||||||.||||.|..
Worm   360 G-PMPGENEPLHAYVTGTDMNVIKKACEKIKQVIAEATALPD-NNELRKLQLRELALLNGTFRPE 422

  Fly   513 DI---QRCT-CGSTDHKSWQCPDKPIITNTIVCTSCGGTGHLTKDCRNKRPGSGVPGMACEDSQA 573
            |:   .||: |||.:||||:|||.|.:||.|.||:||..||::|||:|.:      ||..  |:|
Worm   423 DLANGARCSNCGSDEHKSWECPDAPNVTNQIKCTNCGAFGHISKDCKNPK------GMYA--SEA 479

  Fly   574 KIDEEYMSLMAELGEGPPPPSASAKTDPPASNGPQLHRASYSIFDKKPSQMQAIQSPPSSSSRDH 638
            .:|:||.:|||||||   .|:|.|    .|..|...|.||..         ..|.:...:.....
Worm   480 GMDDEYSALMAELGE---TPAAGA----GAGGGGGGHVASAG---------GGISAMTGAGGEAP 528

  Fly   639 QRDLGGWGAAAH---EHGMGMEHGMG------------------LDQHGHGLAAMDHGMSLGMEH 682
            ....||.|..||   ..|.|.:.|.|                  .:|.....|:|.||.   .:|
Worm   529 GGGAGGRGGGAHGGAGRGGGYQGGRGGGRGFQNPRDLFGPPKGEEEQQQQANASMQHGY---YDH 590

  Fly   683 -AMAAY---------VPAPPG-------TQAPPPMPPPLMPWMSAPQPPPPATEPLNPPIPGTLP 730
             ...||         .|||||       .|...........:.::|.....|....|....|:
Worm   591 YQQYAYPNQYQQPYGAPAPPGGSAYGHQQQQQQQQQQDYSDFYTSPGARGGAGAKANKGWYGS-- 653

  Fly   731 PLIPPPPGTSAP-PMPPWGGGAYSGWGGGYAPPPPPPCAPPPPA--LSLSQPPPPPPPS 786
                 ..|:|.| |:||.||      .||:.||||||  ||.|.  .||....||||||
Worm   654 -----GGGSSMPMPVPPPGG------LGGFMPPPPPP--PPMPGDLSSLLAAAPPPPPS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF1	NP_524654.2	MSL5	253..512	CDD:227503	143/264 (54%)
		SF1-HH	274..385	CDD:292892	60/110 (55%)
		SF1_like-KH	392..510	CDD:239088	74/117 (63%)
sfa-1	NP_503033.1	MSL5	185..422	CDD:227503	139/242 (57%)
sfa-1	NP_503033.1	PTZ00368	<427..>471	CDD:173561	25/43 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167532
Domainoid	1	1.000	129	1.000	Domainoid score	I3287
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1089
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52021
OrthoDB	1	1.010	-	-		D367566at33208
OrthoFinder	1	1.000	-	-		FOG0003999
OrthoInspector	1	1.000	-	-		oto17586
orthoMCL	1	0.900	-	-		OOG6_102013
Panther	1	1.100	-	-	LDO	PTHR11208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R128
SonicParanoid	1	1.000	-	-		X2762
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.840