DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SF1 and Khdrbs3

DIOPT Version :9

Sequence 1:	NP_524654.2	Gene:	SF1 / 43912	FlyBaseID:	FBgn0025571	Length:	787	Species:	Drosophila melanogaster
Sequence 2:	NP_034288.2	Gene:	Khdrbs3 / 13992	MGIID:	1313312	Length:	346	Species:	Mus musculus

Alignment Length:	432	Identity:	108/432 - (25%)
Similarity:	166/432 - (38%)	Gaps:	138/432 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 QEAYLVQFQIEEISRKLRTGDLGITQNPEERSPSPEPIYSSDGKRLNTRE---FRYRKRLEEQRH 365
            :|.||.:...|:                    .|.:|.: :...||..||   |:..:..||:::
Mouse     2 EEKYLPELMAEK--------------------DSLDPSF-THALRLVNREIEKFQKGEGKEEEKY 45

  Fly   366 QLIVKMQTVNPEFKPPADYKPPVTRVSDKVLIPQEQHPDINFVGLLIGPRGNTLKAMEKDTGAKI 430
            ..:|    :|...|           :..|||||.:|.|..||||.|:|||||:||.::::|..|:
Mouse    46 IDVV----INKNMK-----------LGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKM 95

  Fly   431 IIRGKGSV----KEGKVGRKDGQPLPGE-DEPLHAFIT--APNPEAVRK---AVDKIKDVIRQGI 485
            .|.||||:    ||.:: ||.|:..... ::.||..|.  ||..||..:   |:::||..:
Mouse    96 SILGKGSMRDKAKEEEL-RKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFL---- 155

  Fly   486 EVPEGHNDLRRMQLRELAQLNGTLRENDIQRCTCGSTDHKSWQCPDKPIITNTIVCTSCG----- 545
             :|:.::::|:.||:||..|||            ||.:      .|.|::.......:.|
Mouse   156 -IPDYNDEIRQAQLQELTYLNG------------GSEN------ADVPVVRGKSTLRTRGVTTPA 201

  Fly   546 ---GTGHLTKDCRNKRP-GSGVP-------GMACEDSQAKIDEEYMSLMAE----LGEGPPPPSA 595
               |.|.:|     .|| ..|||       |:.............::..|.    .|..||||..
Mouse   202 ITRGRGGVT-----ARPVAVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPP 261

  Fly   596 SAKT----DPPASNGPQLHRASYSIFDKKPSQMQAIQSPPSSSSRDHQRDLGGWGAAAHEHGMGM 656
            :.:|    |.....|......||..:|..       .|.|:.|:.|:.
Mouse   262 TQETYGEYDYDDGYGTAYDEQSYDSYDNS-------YSTPAQSAADYY----------------- 302

  Fly   657 EHGMGLDQHGHGLA--AMDHGMSLGMEHAMAAYVPAPPGTQA 696
                   .:||||:  |.|   |.|.|....:...||....|
Mouse   303 -------DYGHGLSEDAYD---SYGQEEWTNSRHKAPSARTA 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SF1	NP_524654.2	MSL5	253..512	CDD:227503	66/220 (30%)
		SF1-HH	274..385	CDD:292892	16/83 (19%)
		SF1_like-KH	392..510	CDD:239088	50/127 (39%)
Khdrbs3	NP_034288.2	Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:O75525	1..160		58/199 (29%)
		Qua1	5..53	CDD:292891	14/72 (19%)
		SF1_like-KH	58..177	CDD:239088	50/136 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..266		12/53 (23%)
		Sam68-YY	266..320	CDD:293176	17/87 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..346		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810