DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SF1 and KHDRBS1

DIOPT Version :9

Sequence 1:NP_524654.2 Gene:SF1 / 43912 FlyBaseID:FBgn0025571 Length:787 Species:Drosophila melanogaster
Sequence 2:NP_006550.1 Gene:KHDRBS1 / 10657 HGNCID:18116 Length:443 Species:Homo sapiens


Alignment Length:584 Identity:119/584 - (20%)
Similarity:179/584 - (30%) Gaps:251/584 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 QRDQHSQRSSRERTHVNPFDTSNSRNSLNQDHDQSRIPSLFDRQQGLETIREEGREQRFDLTQTI 229
            :||..:.|.||........|.|.:..|:.|  ..||.|.|..|.:                    
Human     3 RRDDPAARMSRSSGRSGSMDPSGAHPSVRQ--TPSRQPPLPHRSR-------------------- 45

  Fly   230 QELMGNAGGNKGFAS----------FFNSQNSNDSTSNGAFDNSADSAAERKRKRKSRWGGSEND 284
                |..||::|.|.          ...|....|:|..|                          
Human    46 ----GGGGGSRGGARASPATQPPPLLPPSATGPDATVGG-------------------------- 80

  Fly   285 KTFIPGMPTILPST------LDPAQQEAYLVQFQIEEISRKLRTGDLGITQNPEERSPSPEPIYS 343
                |....:||.:      ::|  :..||.:...|:.|.     |...|...:..:...|.|..
Human    81 ----PAPTPLLPPSATASVKMEP--ENKYLPELMAEKDSL-----DPSFTHAMQLLTAEIEKIQK 134

  Fly   344 SDGKRLNTREFRYRKRLEEQRHQLIVKMQTVNPEFKPPADYKPPVTRVSDKVLIPQEQHPDINFV 408
            .|.|:.:...:     |:...|:.:                     ::.::||||.:|:|..|||
Human   135 GDSKKDDEENY-----LDLFSHKNM---------------------KLKERVLIPVKQYPKFNFV 173

  Fly   409 GLLIGPRGNTLKAMEKDTGAKIIIRGKGSV----KEGKVGRKDGQPLPGE-DEPLHAFITAPNP- 467
            |.::||:|||:|.::::|||||.:.||||:    ||.:: ||.|.|.... :..||.||....| 
Human   174 GKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEEL-RKGGDPKYAHLNMDLHVFIEVFGPP 237

  Fly   468 -EA---VRKAVDKIKDVIRQGIEVPEGHNDLRRMQLRELAQLNGTLRENDIQRCTCGSTDHKSWQ 528
             ||   :..|::::|..:     ||:..:|:.:.|..||:.|||...                  
Human   238 CEAYALMAHAMEEVKKFL-----VPDMMDDICQEQFLELSYLNGVPE------------------ 279

  Fly   529 CPDKPIITNTIVCTSCGGTGHLTKDCRNKRPGSGVPGMACEDSQAKIDEEYMSLMAELGEGPPPP 593
             |.:                           |.|||                  :...|..||| 
Human   280 -PSR---------------------------GRGVP------------------VRGRGAAPPP- 297

  Fly   594 SASAKTDPPASNGPQLHRASYSIFDKKPSQMQAIQSPPSSSSRDHQRDLGGWGAAAHEHGMGMEH 658
                   ||...|                                             .|:|...
Human   298 -------PPVPRG---------------------------------------------RGVGPPR 310

  Fly   659 G---MGLDQHGHGLAAMDHGMSLGMEHAMAAYVPAPPGTQAPPPMPPPLMPWMSAPQPPPPATE 719
            |   .|....|    |:..|.:      :...||.||..:..|............|.|||||.|
Human   311 GALVRGTPVRG----AITRGAT------VTRGVPPPPTVRGAPAPRARTAGIQRIPLPPPPAPE 364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SF1NP_524654.2 MSL5 253..512 CDD:227503 68/274 (25%)
SF1-HH 274..385 CDD:292892 16/116 (14%)
SF1_like-KH 392..510 CDD:239088 49/127 (39%)
KHDRBS1NP_006550.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 26/148 (18%)
Involved in homodimerization. /evidence=ECO:0000305|PubMed:26758068 100..260 54/196 (28%)
Qua1 102..153 CDD:406639 12/60 (20%)
KH-I_KHDRBS1 152..257 CDD:411896 40/131 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..316 15/133 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 327..346 5/24 (21%)
Interaction with HNRNPA1. /evidence=ECO:0000269|PubMed:17371836 351..443 7/14 (50%)
Sam68-YY 366..415 CDD:406871
Interaction with ZBTB7A. /evidence=ECO:0000269|PubMed:24514149 400..420
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 411..443
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5176
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.