DRSC/TRiP Functional Genomics Resources

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Protein Alignment skd and MED13

DIOPT Version :9

Sequence 1:NP_730591.2 Gene:skd / 43906 FlyBaseID:FBgn0003415 Length:2768 Species:Drosophila melanogaster
Sequence 2:NP_005112.2 Gene:MED13 / 9969 HGNCID:22474 Length:2174 Species:Homo sapiens


Alignment Length:2939 Identity:787/2939 - (26%)
Similarity:1186/2939 - (40%) Gaps:965/2939 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPL------ADPILRSYSRCIQADMLCVW 67
            |||||||||.|.:.|.||.||||:|:| .:.|  :|.|:      .||||.|:|||::||:|.||
Human     8 NGASLEDCHCNLFCLADLTGIKWKKYV-WQGP--TSAPILFPVTEEDPILSSFSRCLKADVLGVW 69

  Fly    68 RRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQA 132
            ||.|.                           ...:||||||:||:|..::|:..:|....    
Human    70 RRDQR---------------------------PGRRELWIFWWGEDPSFADLIHHDLSEEE---- 103

  Fly   133 LWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFT 197
              :|.|:..|:||||:|||||:|||:||.::.::.||.|||||:|....::...: |:|||.|||
Human   104 --DGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINK-SEHLSCSFT 165

  Fly   198 FFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPNG 261
            ||:|||: ||.|:::.:|..|..|::||:|     .|..|:.|                      
Human   166 FFLHGDSNVCTSVEINQHQPVYLLSEEHIT-----LAQQSNSP---------------------- 203

  Fly   262 ASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL--CNK 324
                                 .:|:|.|||:.|.|||.::|.||...:|::.:|..|:|:  |.|
Human   204 ---------------------FQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLK 247

  Fly   325 D-----------NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAE 378
            :           ..|....|||:..|.:|.:|..:|||                           
Human   248 EMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLV--------------------------- 285

  Fly   379 SAVLASLSCPPGAASAPSSMGA---APSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAA 440
                     |......||.:|:   :.|...|...|||...||:  :.|..|..::.:|: :...
Human   286 ---------PQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAM--SSVTLTPPTSPEEV-QTVD 338

  Fly   441 PQAVSALERLAFQPYYDQRPTSGFTFNTNNTH---IPASAAVEMPERTWQDCVMNTLH------- 495
            ||:|.  :.:.|....|     ||..::.:.|   ||...|..:.:|.||:|.||...       
Human   339 PQSVQ--KWVKFSSVSD-----GFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSA 396

  Fly   496 ----VDAAAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDP 556
                :...|.||.|||                                           |:||:.
Human   397 SSGGLCEEATAAKVAS-------------------------------------------WDFVEA 418

  Fly   557 MQKAPCICTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSS 621
            .|:..|.|                            ||        :|:..|.::.....:.|..
Human   419 TQRTNCSC----------------------------LR--------HKNLKSRNAGQQGQAPSLG 447

  Fly   622 YQQQ----H--YHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFH 680
            .|||    |  ..:|...::.|:||.||.         ||..|:|:....::.:|:.|       
Human   448 QQQQILPKHKTNEKQEKSEKPQKRPLTPF---------HHRVSVSDDVGMDADSASQR------- 496

  Fly   681 KRLLHSLASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTP--HGTPHGGASTYSRNSLGGDSS 743
                  |..:|..:...|     ||..|:       .:..||  |||                  
Human   497 ------LVISAPDSQVRF-----SNIRTN-------DVAKTPQMHGT------------------ 525

  Fly   744 MPVASVESPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPA 808
               ....||..|..||||...         .::.:..:|..|.| .:..|.|||     |...|:
Human   526 ---EMANSPQPPPLSPHPCDV---------VDEGVTKTPSTPQS-QHFYQMPTP-----DPLVPS 572

  Fly   809 PTPTDQHDSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSA 873
            ....|:.||.|.:..|...:  :|||..|...|.        .|.....::..:....|      
Human   573 KPMEDRIDSLSQSFPPQYQE--AVEPTVYVGTAV--------NLEEDEANIAWKYYKFP------ 621

  Fly   874 GGAGSGGPSNAIGANAVGTISVKKLEMQ---QQTPSAAMAIKQEP-GAQGRGVGGVTSTTEALNN 934
                                  ||.:::   .|.||.  ..|.:| |..|:  ..|||.||.:..
Human   622 ----------------------KKKDVEFLPPQLPSD--KFKDDPVGPFGQ--ESVTSVTELMVQ 660

  Fly   935 FKRLYNPPKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEGQNH 999
            .|:   |.|::             .|::..:|.:.....:.....:.|.:..| ||  ..||.  
Human   661 CKK---PLKVS-------------DELVQQYQIKNQCLSAIASDAEQEPKIDP-YA--FVEGD-- 704

  Fly  1000 VKPVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQ 1064
                         .:.|..|:...|...|..|.:.....|...|.:.:.       |.|..|.| 
Human   705 -------------EEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSH-------EEDAMSLF- 748

  Fly  1065 GLNIKTEPGLHSPSCKE-----TSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSND 1124
                       |||.|:     ||.:...::|         |.....|..|..||:.|| .|..|
Human   749 -----------SPSIKQDAPRPTSHARPPSTS---------LIYDSDLAVSYTDLDNLF-NSDED 792

  Fly  1125 ECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGN------IQAE 1183
            |.:       |.|...:||.        :|              .|:...|..||      |...
Human   793 ELT-------PGSKKSANGS--------DD--------------KASCKESKTGNLDPLSCISTA 828

  Fly  1184 DLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSN 1248
            ||.||:|||||.||.....||                        ...|.....|::||      
Human   829 DLHKMYPTPPSLEQHIMGFSP------------------------MNMNNKEYGSMDTT------ 863

  Fly  1249 PSNSIMLAAAQAPVTVVAIQTVSKMVKQEYNLELG----SPMEEPINDWDYVYRPPQQEKFVGST 1309
            |..::             ::..|..:..::.:|:.    ||....|.|:.|||:|...:..||.:
Human   864 PGGTV-------------LEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCS 915

  Fly  1310 RYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQK 1374
            .:|||..||||..||:.||..|.|:.:|        |:.|.                        
Human   916 MFAPLKTLPSQYLPPIKLPEECIYRQSW--------TVGKL------------------------ 948

  Fly  1375 LQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSG-GSQY 1438
                                                 :|||:.|..|.        :..| ||  
Human   949 -------------------------------------ELLSSGPSMPF--------IKEGDGS-- 966

  Fly  1439 LLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASP 1503
                 |..|....|...|.....||.|.|..|.........||   :||..|.|..|     .:|
Human   967 -----NMDQEYGTAYTPQTHTSFGMPPSSAPPSNSGAGILPSP---STPRFPTPRTP-----RTP 1018

  Fly  1504 ATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGD-----AGIVSGGTAMA 1563
            .|.                 .|.||.|:.           .|.|.|...     |...|....:.
Human  1019 RTP-----------------RGAGGPASA-----------QGSVKYENSDLYSPASTPSTCRPLN 1055

  Fly  1564 AGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLP 1628
            :...:.:..:||.:|:.||::|.::.:|:|:|.||||..:||||.      ||:|||.|||:|.|
Human  1056 SVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNM------NIKGADVGVYIPDP 1114

  Fly  1629 GVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSS 1693
                                                                             
Human  1115 ----------------------------------------------------------------- 1114

  Fly  1694 SCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLS 1758
                          ..:....||||||||:||:..:.:|||.|||::|.|...|.|:..:.. ..
Human  1115 --------------TQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKR-FE 1164

  Fly  1759 IIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQTSSSSVHRALQ 1823
            .:::.|.::.|                |||.  :.|:|...:..||.|||:              
Human  1165 ALRATSAEHVN----------------GGLK--ESEKLSDDLILLLQDQCT-------------- 1197

  Fly  1824 SHRRRMSRQRRIFGNNGA------PTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMM 1882
                      .:|...||      |.:.:.|....:|..|..:...||||..|     |.|||| 
Human  1198 ----------NLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGR-----QFMDNM- 1246

  Fly  1883 DFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQ 1947
                :|........:.:..|  |.:.|:.::                   .:.:::|:|.:.::|
Human  1247 ----SGGKVDEALVKSSCLH--PWSKRNDVS-------------------MQCSQDILRMLLSLQ 1286

  Fly  1948 PMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRAS----GQCEPQPIPSVVVGYEKD 2008
            |:||:|...|       :....:. |.|||||:|||::|||.|    ...||.|||:.::||:.|
Human  1287 PVLQDAIQKK-------RTVRPWG-VQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYD 1343

  Fly  2009 WISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIR 2073
            ::.::|.::.||::.:||||...||:.|||:||:||.::|..:|:||:|::.||.|:||:|.|:.
Human  1344 YLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVS 1408

  Fly  2074 G--WDGFLQVGAARNNVPADRETTPLDDWLRTLEHAA-----LAEQIRRYAVAFIHQLAPYLSRV 2131
            .  .||.::||:..:...:::...   :|   ...||     ...:::.||....:.|.|||:.:
Human  1409 RLLTDGIMRVGSTASKKLSEKLVA---EW---FSQAADGNNEAFSKLKLYAQVCRYDLGPYLASL 1467

  Fly  2132 PNDKTLLNPPD----------------GSGNSHSKG----------------------------- 2151
            |.|.:||:.|:                .:||:::..                             
Human  1468 PLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTVTSGVAISTSVATANST 1532

  Fly  2152 ---GSSCSSNSSSV-SGLPGGDLP------TDNIKLEPGTEPQVQPMETNEI-------KQEPGV 2199
               .|:.||:||:: ||:....||      :.|.........|...:::.::       .|..|:
Human  1533 LTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSALQTAGI 1597

  Fly  2200 GKGGTAAGETKP------TLILGDPLGM---GETLEDINPSAIVLYVVNPFTF--ASDSCELERL 2253
             .|.:::..|:|      :.:..|.:|:   |::.....|.|||:|:::|||:  ..:|.....:
Human  1598 -SGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAVTYPPAIVVYIIDPFTYENTDESTNSSSV 1661

  Fly  2254 ALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHL 2318
            ..:.||||:.|:::.:|..::|.:::|||..:.:::.....:|:.:...::.||.:.|:||||.|
Human  1662 WTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPL 1726

  Fly  2319 VHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQN 2383
            ..:.:||:|||||....||..|::.|.|  ...::|..||:|||:.::..:      .|...|:.
Human  1727 PTSTNVKTLTGFGPGLAMETALRSPDRP--ECIRLYAPPFILAPVKDKQTE------LGETFGEA 1783

  Fly  2384 EHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIM 2448
            ..:|:|::..||||.||.|:||:.||..||:||...|||||||||||:|:.||...|:||.::.:
Human  1784 GQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCL 1848

  Fly  2449 GIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSAC 2511
            |::..:|..||:||||:|||||.|||.||.|||::.||..||:.||||:.|.:..  .|:|||||
Human  1849 GLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSAC 1913

  Fly  2512 LVTLEPDAKLRVMPDQFTPDERFSQ---ISMQ-NPLATPQDVTCTHILVFPTSAVCAPFTRQFQN 2572
            ||.:||.....:|||..:....|.:   ::|| :.|.||||.:|||||||||||.....:..:..
Human  1914 LVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTT 1978

  Fly  2573 EPQVDDDFLTFEEEGNEDFSDA-------DIGDLFWDTHMDRV-----SNHGSPGRMDDNRSWQS 2625
            | .:|   |.|..  |.|.:|.       |.||   |...|.:     |..|||  :....|...
Human  1979 E-NLD---LAFNP--NNDGADGMGIFDLLDTGD---DLDPDIINILPASPTGSP--VHSPGSHYP 2032

  Fly  2626 AGGNNFK--------CTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVF 2682
            .||:..|        .|.|.  |||.::.|||:::||.||||..|.:|.|||||||..:..||:|
Human  2033 HGGDAGKGQSTDRLLSTEPH--EEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLF 2095

  Fly  2683 LKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRL 2747
            ||.:|||||||:|| |::|:|.::      ||||||.|:||||||||.|||||||..|..|.||.
Human  2096 LKASLHLHVPSVQS-DELLHSKHS------HPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRR 2153

  Fly  2748 SCLPINVQTLMDLY 2761
            |||||:...|..||
Human  2154 SCLPIHFVVLNQLY 2167

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
skdNP_730591.2 Med13_N 15..490 CDD:288451 148/500 (30%)
Med13_C 2234..2755 CDD:283892 232/548 (42%)
MED13NP_005112.2 Med13_N 14..384 CDD:288451 148/500 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 435..477 11/50 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 709..735 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 749..769 6/19 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 787..816 11/58 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 959..1054 30/145 (21%)
LXXLL motif 1 1188..1192 0/3 (0%)
LXXLL motif 2 1279..1283 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1484..1505 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1557..1617 7/60 (12%)
Med13_C 1640..2161 CDD:283892 232/548 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2015..2048 8/34 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148774
Domainoid 1 1.000 331 1.000 Domainoid score I1145
eggNOG 1 0.900 - - E1_KOG3600
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21067
Inparanoid 1 1.050 910 1.000 Inparanoid score I366
Isobase 1 0.950 - 0 Normalized mean entropy S7634
OMA 1 1.010 - - QHG46046
OrthoDB 1 1.010 - - D177884at2759
OrthoFinder 1 1.000 - - FOG0002706
OrthoInspector 1 1.000 - - otm41196
orthoMCL 1 0.900 - - OOG6_104038
Panther 1 1.100 - - O PTHR48249
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2631
SonicParanoid 1 1.000 - - X2492
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.840

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