DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment skd and SSN2

DIOPT Version :9

Sequence 1:	NP_730591.2	Gene:	skd / 43906	FlyBaseID:	FBgn0003415	Length:	2768	Species:	Drosophila melanogaster
Sequence 2:	NP_010731.3	Gene:	SSN2 / 852053	SGDID:	S000002851	Length:	1420	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	174/986 - (17%)
Similarity:	321/986 - (32%)	Gaps:	347/986 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPLADPILRSYSRCIQADMLCVWRRVQSTKTDH 77
            |||..::||.:..:..|.:.::::    .|.:|..:          ||.:.:.   |.|..||
Yeast    10 LEDVLSSFYRVEKIKKINYHQYIS----KAQNDQWS----------IQMEFML---RKQDPKT-- 55

  Fly    78 ADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQALWN------- 135
                               |....:::||.|...::|            |....|:.:
Yeast    56 -------------------LVALLSRDLWCFSINDDP------------VPTPPAIEHKPVSPDK 89

  Fly   136 -GTWKGALT-------YECRSLLFKAL------------HNLMERFVLTKDIVRFGKWFVQPCTS 180
             ||:....:       |   :|..|||            ||         .:::||    ..|.|
Yeast    90 IGTFTADYSKPNLPPHY---ALFLKALRRKIYINLALGSHN---------KLIQFG----NACIS 138

  Fly   181 SDRLFGRSSQHLSFSFTFFVHGD---TVCASIDLREHPAVRPLTKEHLTEA----AAAFAAASSP 238
               |.|..:..:......||:||   ::||     ::..:.|:.:|:|.|:    .|.:.|
Yeast   139 ---LSGVPNYLVQLEPHLFVNGDLTVSLCA-----KNMGLVPMKEENLEESFLSKHALYLA---- 191

  Fly   239 PGSNGSAASAGGAVPNPGQDPNGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIA-GILTGNSYK 302
                                |:|..|......:......||.|. :::|....:: ||...|
Yeast   192 --------------------PSGIRMHLAPASKQGYLITPPKHT-ELLLTTLSVSHGINLQN--- 232

  Fly   303 ASDPIAEKILEDWASFFPLCNKDNTDVPPVVEVVS---GGHKMYHPTNYVLVTDLDDMEHM---- 360
                  :|.|: |.:..|.....|...|.:...::   ...|:..|.:.:....:.|:|:.
Yeast   233 ------KKNLK-WVAVVPDLGHLNGHTPTIASYLTPLLEAKKLVWPLHLIFAQPVADIENSTSGD 290

  Fly   361 ---------------EFVEMQKMQSSVAGAAAESAVLASLSCPPGAASAP-SSMGAAPSA----- 404
                           :|::::  |::.......|.||:|..    |.:.| ||.||....
Yeast   291 PSEFHCLQDALDAIDDFIQLK--QTAAYRTPGSSGVLSSNI----AGTNPLSSDGAYTEQFQHYK 349

  Fly   405 -TAVPLGPASLNAPALAGAGVGATASSAAKEISRKAAPQAVSALERLAFQPYYDQRPTSGFTFNT 468
             .::...|||.::       |..|...:.|:.|..     .:.:::|...|.....|.   ..||
Yeast   350 NNSISSQPASYHS-------VQETNKISPKDFSPN-----FTGIDKLMLSPSDQFAPA---FLNT 399

  Fly   469 NNTHIPASAAVEMPERTW--QDCVMNTLHVDAAAAAAAVAS-STPASGTGSL----SADG--DEN 524
            .|.:|..:......::|.  .|...:.|..:..|...::.. :...|.|||:    :.:|  ::.
Yeast   400 PNNNINENELFNDRKQTTVSNDLENSPLKTELEANGRSLEKVNNSVSKTGSVDTLHNKEGTLEQR 464

  Fly   525 EQNK--PPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNAQCNSSSSISN---------- 577
            |||:  |...|..:|.:::..:.:.:.|  |.|..:      :|:...|:.|||:
Yeast   465 EQNENLPSDKSDSMVDKELFGEDEDEDL--FGDSNK------SNSTNESNKSISDEITEDMFEMS 521

  Fly   578 -----------ISNNKRPQQPLG----------SPALRAAVTGG----SGNKSSSSSSSSSSSSS 617
                       ..|||.....||          .|.:| .::|.    :|.:..........:..
Yeast   522 DEEENNNNKSINKNNKEMHTDLGKDIPFFPSSEKPNIR-TMSGTTKRLNGKRKYLDIPIDEMTLP 585

  Fly   618 SSSSYQQQHYHQQHLQQQQQQRPGTPVLPATAATSSHHS-------SSLSNTSASNSSAATPRRH 675
            :|..|..               ||.| ||.........|       :.:...:..|...:..:..
Yeast   586 TSPLYMD---------------PGAP-LPVETPRDRRKSVFAPLNFNPIIENNVDNKYKSGGKFS 634

  Fly   676 NVPFHK-RLLH---SLASTASSTASTFRAKNHS------------------NTTTDTNIPKQRHL 718
            ..|..| ..|:   |:|..:||.......:|.|                  |.:|:|||.:.:::
Yeast   635 FSPLQKEEALNFDISMADLSSSEEEEDEEENGSSDEDLKSLNVRDDMKPSDNISTNTNIHEPQYI 699

  Fly   719 G-----------------NTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHS 766
            .                 |:.:.      :..:.|..|.:|...:...:.|.|.:|....:|
Yeast   700 NYSSIPSLQDSIIKQENFNSVND------ANITSNKEGFNSIWKIPQNDIPQTESPLKTVDS--- 755

  Fly   767 QPTSVPPAEQLLNM-----------SPHAP----TSVSNLQQPPTPIDHLLDKNTPAPTPTDQHD 816
               |:.|.|..:.|           |...|    :.:|||.:..:.|        |..||.|.:.
Yeast   756 ---SIQPIESNIKMTLEDNNVTSNPSEFTPNMVNSEISNLPKDKSGI--------PEFTPADPNL 809

  Fly   817 S-KSITASPYV 826
            | :|.::.|::
Yeast   810 SFESSSSLPFL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	94/540 (17%)
skd	NP_730591.2	Med13_C	2234..2755	CDD:283892
SSN2	NP_010731.3	Med13_N	8..279	CDD:402956	66/377 (18%)
SSN2	NP_010731.3	Med13_C	1106..1385	CDD:399381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000