Protein Alignment skd and Med13l

DIOPT Version :10

• Sequence 1: NP_730591.2
• Gene: skd / 43906
• FlyBaseID: FBgn0003415
• Length: 2768
• Species: Drosophila melanogaster
• Sequence 2: NP_001334374.1
• Gene: Med13l / 76199
• MGIID: 2670178
• Length: 2216
• Species: Mus musculus
• Alignment Length: 477
• Identity: 92/477 - (19%)
• Similarity: 157/477 - (32%)
• Gaps: 159/477 - (33%)

  Fly   602 LEMLNRL-SKSDDSLGSQFLMS--HPQAS-TGQQEPAKEAAGISHEDSHIVNDVENISGNVVASN 662
            |.::.|: |.|.||.||..:..  |...| |||             |.|:|. |....|:|.|:.
Mouse    11 LSVITRVCSSSSDSSGSTVVREVWHADRSFTGQ-------------DGHLVG-VRQGWGSVKANL 61

  Fly   663 ETLDKRTVSGGGIETEARNLSHVDTERSHDIP--EKQTSSGVLIDINDRF---PQDFLSEIFAKA 722
            .....|.:.|.|    ||.       |....|  ..|.||..:..:|.:|   .|.|:
Mouse    62 HNGPARLLHGSG----ARG-------RCGSGPRGRMQNSSMDVSLMNGQFGTAKQRFI------- 108

  Fly   723 LSDDMPSGANPYQHD---GAGVSLNVENHDPKNWSYFRNLADEQFSDRDVAYIDRTPGFPSDMED 784
                      ||:..   |.|   .||.....|...|| :.||:...:.        .|...:..
Mouse   109 ----------PYRRPSWRGEG---QVEMIGEGNKQRFR-VGDEKKGGKQ--------WFKMTIPH 151

  Fly   785 GGE------IARLHQVAPLTENRVDPQMKVTESEEFDAMVENLRTSDCEQEDEKSETRNAGLPPV 843
            |.:      :..|..:.|:.   ..|....||.::.....|:..|:             :.|..:
Mouse   152 GKKYDKRWLLTSLQNLCPIA---FTPLHYTTEGDKVHFYPEDTGTA-------------SALSKL 200

  Fly   844 GPSLADYDTSGLQIIMNDDLEELKELGSGTFGTVYHGKWRGSDVAIKRIK--KSCFAGRSSEQER 906
            ...:.|.|...:.::||               :.|...:..|::.::.::  |.|.:.|..:.::
Mouse   201 SRRILDSDGQRVVVLMN---------------SCYFPPFLKSELRLEDLELLKFCLSKRFDDSQK 250

  Fly   907 ---LTGEFWGEAEILSKLHHPNVV-----AFYGVVKDGPGATLATVTEYMVDGSLRHVLVRKDRH 963
               || ....:.|::|  |:.:::     ....|:|             ::..|:..:|     .
Mouse   251 SLDLT-SIRTDPELVS--HNVDIILNRKNCMQAVIK-------------IIQESIPELL-----S 294

  Fly   964 LDRRKRLIIAMDAAFGMEYL--HAKNIVHFDLKCDNL-------------LVNLKDPSRPICKVG 1013
            |:..|..:..:|   |:..|  .|.|:...:|.|:.|             ||.|.....|:|
Mouse   295 LNLSKNKLYKLD---GLTELVNKAPNLQSLNLSCNELKSQCELDKVKGFRLVELCLDGNPLC--- 353

  Fly  1014 DFGLSKIKRNTLVSGGVRGTLP 1035
                .:.|..|.....|:...|
Mouse   354 ----DRFKDQTTYISAVQKRFP 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	12..>221	CDD:463303
		PRK07003	<373..>463	CDD:235906
		TALPID3	<721..836	CDD:434634	20/123 (16%)
		MID_MedPIWI	2032..2316	CDD:465699
		Med13_C	2354..2757	CDD:461879
Med13l	NP_001334374.1	Med13_N	13..>223	CDD:463303	59/294 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..368		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	384..403
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..479
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..574
		LXXLL motif 1	664..668
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	731..767
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..847
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1004..1091
		LXXLL motif 2	1224..1228
		Leucine-zipper	1379..1400
		MID_MedPIWI	1415..1757	CDD:465699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1523..1652
		Med13_C	1793..2205	CDD:461879
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2051..2086