DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment skd and Med13l

DIOPT Version :9

Sequence 1:	NP_730591.2	Gene:	skd / 43906	FlyBaseID:	FBgn0003415	Length:	2768	Species:	Drosophila melanogaster
Sequence 2:	NP_001334374.1	Gene:	Med13l / 76199	MGIID:	2670178	Length:	2216	Species:	Mus musculus

Alignment Length:	2951	Identity:	790/2951 - (26%)
Similarity:	1175/2951 - (39%)	Gaps:	941/2951 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGER----PNASSDPLADPILRSYSRCIQADMLC 65
            |...|||||||||:|.::|.:|.|||||::..|..    |..|:....||||.|:.||:||::||
Mouse     6 NWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLC 70

  Fly    66 VWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAAN 130
            ||||  ..|.|                         .|||||||:|:||:|..::..||
Mouse    71 VWRR--DVKPD-------------------------CKELWIFWWGDEPNLVGVIHHEL------ 102

  Fly   131 QALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFS 195
            |.:..|.|:..|:||||:|||||:|||:||.::.|:.||.|||||:|....::...: |:|||.:
Mouse   103 QVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYDKDEKPVNK-SEHLSCA 166

  Fly   196 FTFFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDP 259
            ||||:||:: ||.|:::.:|..:..:.:|||
Mouse   167 FTFFLHGESNVCTSVEIAQHQPIYLINEEHL---------------------------------- 197

  Fly   260 NGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPLCNK 324
                        ..|:::|.|.  :|:::|:|:.|.|||::||.|||.|.|::|:|..|:|:..:
Mouse   198 ------------HMAQSSPAPF--QVLVSPYGLNGTLTGHAYKMSDPAARKLIEEWHCFYPMVLR 248

  Fly   325 D------------NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAA 377
            .            :.|.|..|||:.||.:|.:|:.:|||:..|          ..:..|..|..|
Mouse   249 KREEPREEAELGYDDDFPVAVEVIVGGVRMVYPSAFVLVSQND----------IPVPQSGHGTVA 303

  Fly   378 ESAVLASLSCPPGAASAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEI------- 435
            :..:        |:...||:.|       :||.|.:  :|.....|......|||..:
Mouse   304 QQGL--------GSVKDPSNCG-------MPLTPPT--SPEQVVIGESGGVQSAASHLGSQDGGM 351

  Fly   436 --------SRKAAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMN 492
                    |||..|:..|                                  .|..|.|::|::
Mouse   352 STMHSPKRSRKTPPKLHS----------------------------------HMVRRVWRECIL- 381

  Fly   493 TLHVDAAAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPM 557
                 :.|.:.....|||..         :|...:.|                   ..|:||||.
Mouse   382 -----SRAQSKRSQMSTPTR---------EEEAAHSP-------------------AAWDFVDPT 413

  Fly   558 QKAPCICTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSY 622
            |:..|.|:..:.....::.       |.:|   ||:  :..|.|....||||....:||...::.
Mouse   414 QRVSCSCSRHKLLKRCAVG-------PSRP---PAI--SQPGFSAGLPSSSSLPPPASSKHKTTE 466

  Fly   623 QQQHYHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSL 687
            :|:.      ..:.|:||..|.         ||..|::........|        |..|..|..:
Mouse   467 RQEK------GDKLQKRPLVPF---------HHRPSVAEELCVEQDA--------PGQKLGLAGI 508

  Fly   688 ASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESP 752
              .||...|..|..:........|..||.:|  .|..:||.                |:    ||
Mouse   509 --DASLEVSNTRKYDKQMAVPSRNTSKQMNL--NPMDSPHS----------------PI----SP 549

  Fly   753 ATPAPSPHPNSAHSQ---PTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDH--LLDKNTP----- 807
            ..|..||.|....::   |.|||       ::|....:..:|||..|..|.  |:.:..|
Mouse   550 LPPTLSPQPRGQEAESLDPPSVP-------VNPALYGNGLDLQQLSTIEDRTVLVGQRLPLMAEA 607

  Fly   808 ---------APTPTDQHDS--KSITASPYVHQTPSVE-----PPSYTDHAAGGGPAGGQGLGTGP 856
                     .|:.|:..|.  :|.       :.||.|     ||...      |......|...|
Mouse   608 SETALYSGLRPSYTESSDRWWQSF-------RLPSSEDAEFRPPELQ------GERFDTALDLNP 659

  Fly   857 GSVPAQQ-PATPTAATSAGGAGSGGPSNAIGANAVGTISVKKLEM-QQQTPSA-------AMAIK 912
            .|...|: .|.|.                           |:.:: |.:.|..       ...:.
Mouse   660 ESTALQRLLAQPN---------------------------KRFKIWQDEQPQVQPLPFLDPSPLS 697

  Fly   913 QEPGAQGRGVGGVTSTTEALNNFKRLYNPPKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVK 977
            |:||          .|...:|              ||.:|.|    .::.|.|...:.....|.|
Mouse   698 QQPG----------DTLGEVN--------------DPYTFED----GDIKYIFTANKKCKQGTEK 734

  Fly   978 RPKMEKQRRPRYAKNLYEGQNHVKPVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGL 1042
            ....:.:....:.........|..|| |.     |...:|:..||::
Mouse   735 DSLKKNKSEDGFGTKDVTTPGHSTPV-PD-----GKNAMSIFSSATK------------------ 775

  Fly  1043 VGIANSTASGSDVEADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGL 1107
                      :||..|                               |:.|.:|| |:|.....|
Mouse   776 ----------TDVRQD-------------------------------SAAGRAGS-GSLTQVTDL 798

  Fly  1108 NPSLNDLEQLFETSSNDECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAA 1172
            .|||:||:.:|:.|..||                   ..||:..:...|..| |.:.........
Mouse   799 APSLHDLDNIFDNSDEDE-------------------LGAVSPALRSSKMPT-VGTEERPPGKDG 843

  Fly  1173 AASGAGNIQAEDLTKMFPTPPSHEQQHPNSSPCQT--DVVMTDLSVDTTTTIITSSITTTCNTTI 1235
            .|:|.......||.:|||||||.| |||..||...  |.|.::
Mouse   844 RAAGPYPPTVADLQRMFPTPPSLE-QHPAFSPVMNYKDGVSSE---------------------- 885

  Fly  1236 TSSINTTTTACSNPSNSIMLAAAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPP 1300
                  |.||         |...::|| |..:.|.....:.|....||||..|.|.|:.||::.|
Mouse   886 ------TVTA---------LGMMESPV-VSMVPTHLTEFRMEVEDGLGSPKPEEIKDFSYVHKVP 934

  Fly  1301 QQEKFVGSTRYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQ 1365
            |.:.||||:.:|||..|||....||..|..|.::|:|:.
Mouse   935 QFQPFVGSSMFAPLKTLPSHCLLPLKTPDACLFRPSWAV-------------------------- 973

  Fly  1366 QRIQLHQQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQP 1430
                  ..|::||.:           ..||:|...|:                      :.||..
Mouse   974 ------PPKMEQLPM-----------PPAASSIRDGY----------------------NNVPSV 999

  Fly  1431 LSSGGSQYL-LNQLNCP----QAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHP 1490
            .|.....|| ..|:|.|    .|.|.::     ..||:.|       .|...|.|..:..||..|
Mouse  1000 GSLADPDYLNTPQMNTPVTLNSAAPASN-----SGAGVLP-------SPATPRFSVPTPRTPRTP 1052

  Fly  1491 PPP-----------YPYDLA-VASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGH 1543
            ..|           ..||.. ..|||::.|:  .|||:|.|
Mouse  1053 RTPRGGGTASGQGSVKYDSTDQGSPASTPST--TRPLNSVE------------------------ 1091

  Fly  1544 MGMVAYTGDAGIVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNA 1608
                                   .:.:|.:||.:|:.|.::|.|:.:|||:|.||||..:|.||.
Mouse  1092 -----------------------PATMQPIPEAHSLYVTLILSDSVMNVFKDRNFDSCCICACNM 1133

  Fly  1609 DTQKIGNIRGADSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASA 1673
                  ||:|||.|:|:|
Mouse  1134 ------NIKGADVGLYIP----------------------------------------------- 1145

  Fly  1674 SMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDE 1738
                             :||.               :|...|||||||:|||:|.:.:|||.|||
Mouse  1146 -----------------DSSK---------------EDQYRCTCGFSAIVNRKLGYNSGLFLEDE 1178

  Fly  1739 VEITGIADDPGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDL 1803
            ::|.|...|.|           |:..|:....|..|:::......||...|...:..|      |
Mouse  1179 LDIFGKNSDIG-----------QAAERRLMMCQSSGQSTLLPQVEGARKAPEPPVSLL------L 1226

  Fly  1804 LLDQCSIIQTSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANVLEFMDAHDVISLALEQ 1868
            ||.                ..|.:              |.||| |..:.:...:.|.:..::...
Mouse  1227 LLQ----------------NQHTQ--------------PFASL-SFLDYISSANRHALPCVSWTY 1260

  Fly  1869 SRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRL--------TVHKW 1925
            .|:..:|.      |:.....::..|.:|    :...|.         .|::        |||.|
Mouse  1261 DRVQADNN------DYWTECFNALEQGRQ----YVDNPT---------GGKVDEALVRSATVHCW 1306

  Fly  1926 PYLPVGFTR--SNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGR 1988
            |:..|..|.  |::::||.:.::||.||:|...|..|    :...:...|.|||||:|||::|||
Mouse  1307 PHSNVLDTSMLSSQDVVRMLLSLQPFLQDAIQKKRTG----RTWENIQHVQGPLTWQQFHKMAGR 1367

  Fly  1989 ----ASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNC 2049
                :....||.|||:::|||:|::::::|.|:.:|::.|||||...|||.|:||||:||.::..
Mouse  1368 GTYGSEESPEPLPIPTLLVGYDKEFLTISPFSLPFWERLLLEPYGGHRDVAYIVVCPENEALLEG 1432

  Fly  2050 TRSYFRELSSTYEMCKLGKHTPI----RGWDGFLQVGAARNNVPADRETTPL-DDWLR---TLEH 2106
            .:::||:||:.||||:||:|.||    |  ||.::||    ...|.:.|..| .:|..   :.|.
Mouse  1433 AKTFFRDLSAVYEMCRLGQHKPICKVLR--DGIMRVG----KTVAQKLTEELVSEWFNQPWSSEE 1491

  Fly  2107 AALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPP-------DGSGNSHSKGGSSCSSNSSSVSG 2164
            :....:::.||....|.|||||:.:..|..||.||       :..|.:......|..|||.| ..
Mouse  1492 SDNHSRLKLYAQVCRHHLAPYLATLQLDSGLLMPPKHQSPPAEAQGQATPGNAGSLPSNSGS-GA 1555

  Fly  2165 LPGGDL--PTDNIKLEPGTE----------------PQVQPMETNEIK--------QEPGVG--- 2200
            .|.|..  ||.:....|.|.                |.:..|.|....        |.|..|
Mouse  1556 PPAGSAFNPTSSSSANPTTSSSSASSGPPGSSAASAPGITQMNTTSSSGFGGGVGGQNPSAGGSS 1620

  Fly  2201 ----KGGTAAGETKPTLI-----------------LGDPLGMGETLEDINPSAIVLYVVNPFTF- 2243
                .|..|.|:|:|...                 :|.|...........|.|:|:|:|:|||:
Mouse  1621 TDRTPGNVACGDTEPGQSCTQSSQDGQDSVTERERIGIPTEPDSADSHAYPPAVVIYMVDPFTYT 1685

  Fly  2244 ASDSCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDE------ 2302
            |.:........|::|:|||.|:|..:|:.:||...:||:..:.:::        ...||
Mouse  1686 AEEDSSSGNFWLLSLMRCYTEMLDHLPEHMRSSFILQIVPCQYMLQ--------TMKDEHVFYIQ 1742

  Fly  2303 -IRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHER 2366
             ::.:|.:::.||||.|.....:|||||||.||::|..||..:.|:  ..::|:.||:|||:.::
Mouse  1743 YLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPS--PIQLYSPPFILAPIKDK 1805

  Fly  2367 NDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPN----- 2426
            ..:      .|...|:...:|:|::..||||.||.||||:.||..||:||...:||.:|:
Mouse  1806 QTE------PGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCVVNIALPSRTLHV 1864

  Fly  2427 ----RARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQK 2487
                |:|:.|..||.|.|:||.::.:||:..||..||:||||:||:||.|||.||.||.:..||.
Mouse  1865 PLSVRSRKSKVSARKVGLQKLWEWCLGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQT 1929

  Fly  2488 ASKQFKDMCKQCTLMY--PPTILSACLVTLEPDAKLRVMPDQFTPDERFSQ---ISMQ-NPLATP 2546
            .|||.||:|:.|.:..  .|:|||||||.:||.....||||..|....|.:   ::|| :.|.||
Mouse  1930 ISKQLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTP 1994

  Fly  2547 QDVTCTHILVFPTSAVCAPFTRQFQNE----PQVDDDF--LTFEEEGNEDFSDADIGDLFWDTHM 2605
            ||.:||||||||||:........:.||    |..||.|  |.|.::.:.|......|:|....:.
Mouse  1995 QDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNS 2059

  Fly  2606 DRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWS 2670
            ..|.:.|||..:.....:|.:.....:....:..||   |.|||:::||.||||....:|.||||
Mouse  2060 SPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEE---LKQQPLALGYFVSTAKAENLPQWFWS 2121

  Fly  2671 ACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALS 2735
            :||...:.||:|||.:||.|: |:...|::|.:..:.::  .|||||..|:||||||||.|||||
Mouse  2122 SCPQARNQCPLFLKASLHHHI-SVAQTDELLPARTSQRA--PHPLDSKTTSDVLRFVLEQYNALS 2183

  Fly  2736 WLALDSNTHDRLSCLPINVQTLMDLY 2761
            ||..:..|.||.||||::...|..||
Mouse  2184 WLTCNPATQDRTSCLPVHFVVLTQLY 2209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	145/506 (29%)
skd	NP_730591.2	Med13_C	2234..2755	CDD:283892	215/549 (39%)
Med13l	NP_001334374.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..368		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..403		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..479		15/65 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..574		18/83 (22%)
		LXXLL motif 1	664..668		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..767		7/41 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..847		7/50 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1091		27/100 (27%)
		LXXLL motif 2	1224..1228		2/9 (22%)
		Leucine-zipper	1379..1400		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1523..1652		26/129 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2051..2086		7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838859
Domainoid	1	1.000	332	1.000	Domainoid score	I1141
eggNOG	1	0.900	-	-		E1_KOG3600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	915	1.000	Inparanoid score	I361
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46046
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	1	1.000	-	-		otm43261
orthoMCL	1	0.900	-	-		OOG6_104038
Panther	1	1.100	-	-	LDO	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2631
SonicParanoid	1	1.000	-	-		X2492
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.880