DRSC/TRiP Functional Genomics Resources

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Protein Alignment skd and Med13

DIOPT Version :9

Sequence 1:NP_730591.2 Gene:skd / 43906 FlyBaseID:FBgn0003415 Length:2768 Species:Drosophila melanogaster
Sequence 2:NP_001074400.1 Gene:Med13 / 327987 MGIID:3029632 Length:2171 Species:Mus musculus


Alignment Length:2922 Identity:792/2922 - (27%)
Similarity:1192/2922 - (40%) Gaps:932/2922 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPL------ADPILRSYSRCIQADMLCV 66
            :|||||||||.|.:.|.||.||||:::| .:.|  :|.|:      .||||.|:|||::||:|.|
Mouse     7 SNGASLEDCHCNLFCLADLTGIKWKRYV-WQGP--TSAPILFPVTEEDPILSSFSRCLKADVLGV 68

  Fly    67 WRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQ 131
            |||.|.                           ...:||||||:|::|:.::|:..:|....   
Mouse    69 WRRDQR---------------------------PGRRELWIFWWGKDPNFADLIHHDLSEEE--- 103

  Fly   132 ALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSF 196
               :|.|:..|:||||:|||||:|||:||.::.::.||.|||||:|....::...: |:|||.||
Mouse   104 ---DGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINK-SEHLSCSF 164

  Fly   197 TFFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPN 260
            |||:|||: ||.|:::.:|..|..|::||:|     .|..|:.|                     
Mouse   165 TFFLHGDSNVCTSVEINQHQPVYLLSEEHVT-----LAQQSNSP--------------------- 203

  Fly   261 GASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL-C-- 322
                                  .:|:|:|||:.|.|||.::|.||...:|::.:|..|:|: |  
Mouse   204 ----------------------FQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCGL 246

  Fly   323 ------NKDNTDVP----PVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAA 377
                  .:|:.|..    ..|||:..|.:|.:|..:|||                          
Mouse   247 KEMSEEKQDDMDWEDDSLAAVEVLVAGVRMIYPACFVLV-------------------------- 285

  Fly   378 ESAVLASLSCPPGAASAPSSMGAAPSATAVPLG----PASLNAPALAGAGVGATASSAAKEISRK 438
                      |.....||||:||: ..:|..||    |||...||:  :.|..|..::.:|: :.
Mouse   286 ----------PQSDIPAPSSVGAS-HCSASCLGIHQVPASTRDPAM--SSVTLTPPTSPEEV-QT 336

  Fly   439 AAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTH---IPASAAVEMPERTWQDCVMNTLHVDAAA 500
            ..||  ||.:.:.|....|     ||:.::.:.|   ||...|..:.:|.||:|.||.|      
Mouse   337 VDPQ--SAQKWVKFSSVSD-----GFSTDSTSHHGGKIPRKLANHVVDRVWQECNMNRL------ 388

  Fly   501 AAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKL--WNFVDPMQKAPCI 563
                                     |||....:   ....:.:::...|:  |:||:..|:..|.
Mouse   389 -------------------------QNKRKYSA---TSSGLCEEETADKIGCWDFVEATQRTSCS 425

  Fly   564 CTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQ--- 625
            |                            ||        :||..:.::.....:.|...|||   
Mouse   426 C----------------------------LR--------HKSLKTRNTGQQGQAPSLGQQQQVLP 454

  Fly   626 -H--YHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSL 687
             |  ..:|...::.|:||.||.         ||..|:|:....::.:|:.|             |
Mouse   455 KHKTNEKQDKSEKPQKRPLTPF---------HHRVSVSDEIGMDTDSASQR-------------L 497

  Fly   688 ASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTP--HGTPHGGASTYSRNSLGGDSSMPVASVE 750
            ..:|:.:...|     ||..|:       .:..||  |||                     ....
Mouse   498 VISAADSQVRF-----SNIRTN-------DVAKTPQMHGT---------------------ELAN 529

  Fly   751 SPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQH 815
            ||..|..||||...         .::.:..:|..|.| .:..|.|||     |...|.....|:.
Mouse   530 SPQPPPLSPHPCDV---------VDEGVTKTPSTPQS-QHFYQMPTP-----DPLVPTKPMEDRI 579

  Fly   816 DSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGG 880
            ||.|.:..|...:  :|||..|...|.        .|.....:|..:....|             
Mouse   580 DSLSQSFPPPFQE--AVEPTVYVGTAV--------SLEEDEANVAWKYYKVP------------- 621

  Fly   881 PSNAIGANAVGTISVKKLEMQ---QQTPSAAMAIKQEP-GAQGRGVGGVTSTTEALNNFKRLYNP 941
                           ||.:::   .|.|:.  ..|.:| |..|:  ..|||.||.:...|:    
Mouse   622 ---------------KKKDVEFLPPQLPND--KFKDDPVGPFGQ--ESVTSVTELMVQCKK---- 663

  Fly   942 PKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEGQNHVKPVMPS 1006
               .||..|....:..:|.     ||.......|.:.||::.     ||  ..||.         
Mouse   664 ---PLKVSDEIVQQYQIKN-----QYLSAIASDTEQEPKIDP-----YA--FVEGD--------- 704

  Fly  1007 PGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTE 1071
                  .:.:..|:...|...|..|.:.....|...|.:.:.       |.|..|.|        
Mouse   705 ------EEFIFTDKKDRQNSEREAGKKHKVEDGTSAVTVLSH-------EEDAMSLF-------- 748

  Fly  1072 PGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPD 1136
                |||.::..:.:  |.:...|.|   |.....|..|..||:.|| .|..||.:       |.
Mouse   749 ----SPSKQDAPRPT--NHARPPSTS---LIYDSDLAVSYTDLDNLF-NSDEDELT-------PG 796

  Fly  1137 SNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGN------IQAEDLTKMFPTPPSH 1195
            |...::|.        :|              .|::..|..||      |...||.||:|||||.
Mouse   797 SKKSASGS--------DD--------------KASSKESKTGNLDPLSCISTADLHKMYPTPPSL 839

  Fly  1196 EQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLAAAQA 1260
            ||.....||                        ...|.....|::|.      |..::       
Mouse   840 EQHIMGFSP------------------------MNMNNKEYGSVDTA------PGGTV------- 867

  Fly  1261 PVTVVAIQTVSKMVKQEYNLELG----SPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQT 1321
                  ::..|..|..::.:|:.    ||....|.|:.|||:|...:..||.:.:|||..|||..
Mouse   868 ------LEGNSSSVGTQFRIEVEEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSHC 926

  Fly  1322 QPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQ 1386
            .||:.||..|.|:.:|        |:.|.                                    
Mouse   927 LPPIKLPEECVYRQSW--------TVGKL------------------------------------ 947

  Fly  1387 QAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSG-GSQYLLNQLNCPQAPP 1450
                                     |||.:.|..|.        :..| ||.  |:|...|...|
Mouse   948 -------------------------DLLPSGPSMPF--------IKEGDGSN--LDQDYGPAYTP 977

  Fly  1451 GASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPL 1515
                 |.....||.|.|..|..|......||   :||..|.|..|     .:|.|.         
Mouse   978 -----QTHASFGMPPSSAPPSNGGAGILPSP---STPRFPTPRTP-----RTPRTP--------- 1020

  Fly  1516 HSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGD-----AGIVSGGTAMAAGSSSLLQELPE 1575
                    .|.||.|:.           .|.|.|...     |...|....:.:...:.:..:||
Mouse  1021 --------RGAGGPASA-----------QGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPE 1066

  Fly  1576 VNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSGAG 1640
            .:|:.||::|.::.:|:|:|.||||..:||||.      ||:|||.|||:|.|            
Mouse  1067 AHSLYVNLILSESVMNLFKDCNFDSCCICVCNM------NIKGADVGVYIPDP------------ 1113

  Fly  1641 GALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHIT 1705
                                                                             
Mouse  1114 ----------------------------------------------------------------- 1113

  Fly  1706 GYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQNK 1770
              ..:....||||||||:||:..:.:|||.|||::|.|...|.|                |...|
Mouse  1114 --TQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCG----------------KEAEK 1160

  Fly  1771 QGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRRI 1835
            :.....:|:::.:. |||.  :.|::...:..||.|||:                        .:
Mouse  1161 RFEALRASSVENVN-GGLK--ESEKVPDELILLLQDQCT------------------------NL 1198

  Fly  1836 FGNNGA------PTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSHQ 1894
            |...||      |...::|....:|..|......||||..|     |.||||        |....
Mouse  1199 FSPFGAADQDPFPKVGISSNWVRVEERDCCSDCCLALEHGR-----QFMDNM--------SGGKV 1250

  Fly  1895 QQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSR 1959
            .:.|.....                  :|.|........:.:::|:|.:.::||:||:|...|  
Mouse  1251 DEALVRSSC------------------LHPWAKQNDASVQCSQDILRMLLSLQPVLQDAIQKK-- 1295

  Fly  1960 GGSGSKDASSYNTVSGPLTWRQFHRLAGRAS----GQCEPQPIPSVVVGYEKDWISVAPHSIHYW 2020
                 :....:. |.|||||:|||::|||.|    ...||.|||:.::||:.|::.::|.::.||
Mouse  1296 -----RTVRPWG-VQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYW 1354

  Fly  2021 DKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIRG--WDGFLQVGA 2083
            :|.:||||...||:.|||:||:||.::|..||:||:|::.||.|:||:|.||..  .||.::|||
Mouse  1355 EKLMLEPYGSQRDIAYVVLCPENEALLNGARSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVGA 1419

  Fly  2084 ARNNVPADRETTPLDDWLRTLEHAA-----LAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPD- 2142
            ..:...:::..|   :|   ...||     ...:::.||....:.|.|||:..|.|.:||:.|: 
Mouse  1420 TASKKLSEKFVT---EW---FSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNL 1478

  Fly  2143 ---------------GSGNSHSKGG-------------------------------SSCSSNSSS 2161
                           .:||:::...                               :|.||:||.
Mouse  1479 VAPPNQSLVTAPQMTNTGNANAPSATLASAASSTMTMTSGVPISTSVATANSTLTTTSSSSSSSL 1543

  Fly  2162 VSGLPGGDLP------------TDNIKLEPGT--EPQVQPMETNEIKQEPGVGKGGTAAGETKP- 2211
            .||:....||            |.::..:..|  ..|:...:::.: |..|: .|.:|:..|:| 
Mouse  1544 SSGVSSNKLPSFPPFGSMNTSGTGSMSAQASTVQSGQLGGQQSSSL-QAAGI-SGESASLPTQPH 1606

  Fly  2212 -----TLILGDPLGM---GETLEDINPSAIVLYVVNPFTFAS--DSCELERLALIALLRCYAELL 2266
                 :.:..|.:|:   |::.....|.|||:|:::|||:.:  :|.....:..:.||||:.|::
Mouse  1607 PDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMV 1671

  Fly  2267 KAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFG 2331
            :.:|..::|.:::||:..:.:::.....:|:.:|..::.||.::|:||||.|..:.:||:|||||
Mouse  1672 QTLPPHIKSTVSVQIVPCQYLLQPVKHDDRQIYSQHLKSLAFSVFTQCRRPLPTSTNVKTLTGFG 1736

  Fly  2332 TAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCL 2396
            ....||..||:.|.|  ...::||.||:|||:.::..:      .|...|:...:|:|::..|||
Mouse  1737 PGLAMETALKSPDRP--ECIRLYTPPFILAPVKDKQTE------LGETFGEAGQKYNVLFVGYCL 1793

  Fly  2397 SEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLV 2461
            |.||.|:||:.||..||:||...|||||||||||:|..||...|:||.::.:|::..:|..||:|
Mouse  1794 SHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVV 1858

  Fly  2462 IGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSACLVTLEPDAKLRVM 2524
            |||:|||||.|||.||.|||::.||..||:.||||:.|.:..  .|:|||||||.:||.....:|
Mouse  1859 IGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIM 1923

  Fly  2525 PDQFTPDERFSQ---ISMQNP-LATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEE 2585
            ||..:....|.:   ::||.| |.||||.:|||||||||||.....:..:..| .:|   |.|..
Mouse  1924 PDSVSTGSVFGRSTTLNMQTPQLNTPQDTSCTHILVFPTSASVQVASATYTTE-NLD---LAFNP 1984

  Fly  2586 EGNEDFSDA-------DIGDLFWDTHMDRV---------SNHGSPGRMDDNRSWQSAGGNNFKCT 2634
              |.|.:|.       |.||   |...|.:         |...|||....:......|....:..
Mouse  1985 --NNDGADGMGIFDLLDTGD---DLDPDIINILPASPTASPVHSPGSHYPHGGDAGKGQGTDRLL 2044

  Fly  2635 PPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADD 2699
            ..:..:||.::.|||:::||.||||..|.:|.|||||||..:..||:|||.:|||||||:|| |:
Mouse  2045 STESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQS-DE 2108

  Fly  2700 ILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLY 2761
            :|:|.::      ||||||.|:||||||||.|||||||..|....||.||||::...|..||
Mouse  2109 LLHSKHS------HPLDSNQTSDVLRFVLEQYNALSWLTCDPAVQDRRSCLPVHFVVLNQLY 2164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
skdNP_730591.2 Med13_N 15..490 CDD:288451 151/501 (30%)
Med13_C 2234..2755 CDD:283892 227/544 (42%)
Med13NP_001074400.1 Med13_N 14..384 CDD:288451 151/501 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..339 5/23 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..476 10/41 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 711..733 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..768 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..820 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 957..1053 33/146 (23%)
LXXLL motif 1 1187..1191 0/3 (0%)
LXXLL motif 2 1278..1282 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1483..1503 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1532..1626 20/95 (21%)
Med13_C 1637..2158 CDD:283892 227/544 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2012..2042 5/29 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838858
Domainoid 1 1.000 332 1.000 Domainoid score I1141
eggNOG 1 0.900 - - E1_KOG3600
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21067
Inparanoid 1 1.050 915 1.000 Inparanoid score I361
Isobase 1 0.950 - 0 Normalized mean entropy S7634
OMA 1 1.010 - - QHG46046
OrthoDB 1 1.010 - - D177884at2759
OrthoFinder 1 1.000 - - FOG0002706
OrthoInspector 1 1.000 - - otm43261
orthoMCL 1 0.900 - - OOG6_104038
Panther 1 1.100 - - O PTHR48249
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2631
SonicParanoid 1 1.000 - - X2492
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1615.840

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