DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment skd and Med13

DIOPT Version :9

Sequence 1:NP_730591.2 Gene:skd / 43906 FlyBaseID:FBgn0003415 Length:2768 Species:Drosophila melanogaster
Sequence 2:XP_038941974.1 Gene:Med13 / 303403 RGDID:1304829 Length:2171 Species:Rattus norvegicus


Alignment Length:2921 Identity:793/2921 - (27%)
Similarity:1183/2921 - (40%) Gaps:930/2921 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 TNGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPL------ADPILRSYSRCIQADMLCV 66
            :|||||||||.|.:.|.||.||||:::| .:.|  :|.|:      .||||.|:|||::||:|.|
  Rat     7 SNGASLEDCHCNLFCLADLTGIKWKRYV-WQGP--TSAPILFPVTEEDPILSSFSRCLKADVLGV 68

  Fly    67 WRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQ 131
            |||.|.                           ...:||||||:|::|:.::|:..:|....   
  Rat    69 WRRDQR---------------------------PGRRELWIFWWGKDPNFADLIHHDLSEEE--- 103

  Fly   132 ALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSF 196
               :|.|:..|:||||:|||||:|||:||.::.::.||.|||||:|....::...: |:|||.||
  Rat   104 ---DGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINK-SEHLSCSF 164

  Fly   197 TFFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPN 260
            |||:|||: ||.|:::.:|..|..|::||:|     .|..|:.|                     
  Rat   165 TFFLHGDSNVCTSVEINQHQPVYLLSEEHVT-----LAQQSNSP--------------------- 203

  Fly   261 GASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL-C-- 322
                                  .:|:|:|||:.|.|||.::|.||...:|::.:|..|:|: |  
  Rat   204 ----------------------FQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCGL 246

  Fly   323 -------NKD---NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAA 377
                   .:|   ..|....|||:..|.:|.:|..:|||                          
  Rat   247 KEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLV-------------------------- 285

  Fly   378 ESAVLASLSCPPGAASAPSSMGAAPSATAVPLG----PASLNAPALAGAGVGATASSAAKEISRK 438
                      |......|||:|:: ..:|..||    |||...||:  :.|..|..::.:|: :.
  Rat   286 ----------PQSDIPTPSSVGSS-HCSASCLGIHQVPASTRDPAM--SSVTLTPPTSPEEV-QS 336

  Fly   439 AAPQAVSALERLAFQPYYDQRPTSGFTFNTNNTH---IPASAAVEMPERTWQDCVMNTLHVDA-- 498
            ..||  ||.:.:.|....|     ||:.::.:.|   ||...|..:.:|.||:|.||.|....  
  Rat   337 VDPQ--SAQKWVKFSSVSD-----GFSTDSTSHHGGKIPRKLANHVVDRVWQECNMNRLQNKRKY 394

  Fly   499 AAAAAAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCI 563
            :|.::.:.....|...||                                  |:||:..|:..|.
  Rat   395 SATSSGLCEEETADKIGS----------------------------------WDFVEATQRTSCS 425

  Fly   564 CTNAQCNSSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQ--- 625
            |                            ||        :||..:.::.....:.|...|||   
  Rat   426 C----------------------------LR--------HKSLKTRNTGQQGQAPSLGQQQQILP 454

  Fly   626 -H--YHQQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSL 687
             |  ..:|...::.|:||.||.         ||..|:|:....::.:|:.|             |
  Rat   455 KHKTNEKQEKSEKPQKRPLTPF---------HHRVSISDDIGMDTDSASQR-------------L 497

  Fly   688 ASTASSTASTFRAKNHSNTTTDTNIPKQRHLGNTP--HGTPHGGASTYSRNSLGGDSSMPVASVE 750
            ..:|:.:...|           ||| :...:..||  |||                     ....
  Rat   498 VISAADSQVRF-----------TNI-RTNDVAKTPQMHGT---------------------ELAN 529

  Fly   751 SPATPAPSPHPNSAHSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQH 815
            ||..|..||||...         .::.:..:|..|.| .:..|.|||     |...|.....|:.
  Rat   530 SPQPPPLSPHPCDV---------VDEGVTKTPSTPQS-QHFYQMPTP-----DPLVPTKPMEDRI 579

  Fly   816 DSKSITASPYVHQTPSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGG 880
            ||.|.:..|...:  :|||..|...|.        .|.....:|..:....|             
  Rat   580 DSLSQSFPPPFQE--AVEPTVYVGTAV--------SLEEDEANVAWKYYKVP------------- 621

  Fly   881 PSNAIGANAVGTISVKKLEMQ---QQTPSAAMAIKQEP-GAQGRGVGGVTSTTEALNNFKRLYNP 941
                           ||.:::   .|.|:.  ..|.:| |..|:  ..|||.||.:...|:    
  Rat   622 ---------------KKKDVEFLPPQLPND--KFKDDPVGPFGQ--ESVTSVTELMVQCKK---- 663

  Fly   942 PKLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEGQNHVKPVMPS 1006
               .||..|....:..:|.     ||.......|.:.||::.     ||  ..||.         
  Rat   664 ---PLKVSDEIVQQYQIKN-----QYLSAIASDTEQEPKIDP-----YA--FVEGD--------- 704

  Fly  1007 PGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTE 1071
                  .:.:..|:...|...|..|.:.....|...|.:.:.       |.|..|.|        
  Rat   705 ------EEFIFTDKKDRQNSEREAGKKHKVEDGTSAVTVLSH-------EEDAMSLF-------- 748

  Fly  1072 PGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQIHTPPD 1136
                |||.::..:.:  |.:...|.|   |.....|..|..||:.|| .|..||.:       |.
  Rat   749 ----SPSKQDAPRPA--NHARPPSTS---LIYDSDLAVSYTDLDNLF-NSDEDELT-------PG 796

  Fly  1137 SNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGN------IQAEDLTKMFPTPPSH 1195
            |...::|.        :|              .|::..|..|:      |...||.||:|||||.
  Rat   797 SKKSASGS--------DD--------------KASSKESKTGSLDPLSCISTADLHKMYPTPPSL 839

  Fly  1196 EQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLAAAQA 1260
            ||.....||                        ...|.....|::.|      |..:::..::.:
  Rat   840 EQHIMGFSP------------------------MNMNNKEYGSMDPT------PGGTVLEGSSSS 874

  Fly  1261 PVTVVAIQTVSKMVKQEYNLELG--SPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQTQP 1323
            ..|...|:           :|.|  ||....|.|:.|||:|...:..||.:.:|||..|||...|
  Rat   875 VGTQFRIE-----------VEEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSHCLP 928

  Fly  1324 PLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQA 1388
            |:.||..|.|:.:|        |:.|.                                      
  Rat   929 PIKLPEECVYRQSW--------TVGKL-------------------------------------- 947

  Fly  1389 AAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSG-GSQYLLNQLNCPQAPPGA 1452
                                   |||.:.|..|.        :..| ||.  |:|...|...|  
  Rat   948 -----------------------DLLPSGPSMPF--------IKEGDGSN--LDQDYGPAYTP-- 977

  Fly  1453 SMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPPYPYDLAVASPATSTSSYLNRPLHS 1517
               |:....||.|.|..|..|......||   :||..|.|..|     .:|.|.           
  Rat   978 ---QIHTSFGMPPSSAPPSNGGAGILPSP---STPRFPTPRTP-----RTPRTP----------- 1020

  Fly  1518 QEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGD-----AGIVSGGTAMAAGSSSLLQELPEVN 1577
                  .|.||.|:.           .|.|.|...     |...|....:.:...:.:..:||.:
  Rat  1021 ------RGAGGPASA-----------QGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAH 1068

  Fly  1578 SVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGADSGVYVPLPGVSFNPFPSGAGGA 1642
            |:.||::|.::.:|:|:|.||||..:||||.      ||:|||.|||:|.|              
  Rat  1069 SLYVNLILSESVMNLFKDCNFDSCCICVCNM------NIKGADVGVYIPDP-------------- 1113

  Fly  1643 LAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGHGPNGGSNSSSCTPPSSNPHITGY 1707
                                                                             
  Rat  1114 ----------------------------------------------------------------- 1113

  Fly  1708 VDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADDPGRNKQPTLLSIIQSLSRKNQNKQG 1772
            ..:....||||||||:||:..:.:|||.|||::|.|...|.|                |...|:.
  Rat  1114 TQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCG----------------KEAEKRF 1162

  Fly  1773 PGETSSALDKIGAGGLPNGQL---EQLGHAVFDLLLDQCSIIQTSSSSVHRALQSHRRRMSRQRR 1834
            ....:|:::.:      ||.|   |::...:..||.|||:                        .
  Rat  1163 EALRASSVENV------NGSLKESEKVPDELILLLQDQCT------------------------N 1197

  Fly  1835 IFGNNGA------PTASLASIANVLEFMDAHDVISLALEQSRLAFENQRMDNMMDFHGNGSSSSH 1893
            :|...||      |.|.::|....:|..|......||||..|     |.||||        |...
  Rat  1198 LFSPFGAADHDPFPKAGISSNWVRVEERDCCSDCCLALEHGR-----QFMDNM--------SGGK 1249

  Fly  1894 QQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSNKEIVRTMNAIQPMLQNAFHCKS 1958
            ..:.|.....                  :|.|........:.:::|:|.:.::||:||:|...| 
  Rat  1250 VDEALVRSSC------------------LHPWAKQNDASVQCSQDILRMLLSLQPVLQDAIQKK- 1295

  Fly  1959 RGGSGSKDASSYNTVSGPLTWRQFHRLAGRAS----GQCEPQPIPSVVVGYEKDWISVAPHSIHY 2019
                  :....:. |.|||||:|||::|||.|    ...||.|||:.::||:.|::.::|.::.|
  Rat  1296 ------RTVRPWG-VQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPY 1353

  Fly  2020 WDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPIRG--WDGFLQVG 2082
            |:|.:||||...||:.|||:||:||.::|..||:||:|::.||.|:||:|.||..  .||.::||
  Rat  1354 WEKLMLEPYGSQRDIAYVVLCPENEALLNGARSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVG 1418

  Fly  2083 AARNNVPADRETTPLDDWLRTLEHAA-----LAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNPPD 2142
            |..:...:::..|   :|   ...||     ...:::.||....:.|.|||:..|.|.:||:.|:
  Rat  1419 ATASKKLSEKFVT---EW---FSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPN 1477

  Fly  2143 ----------------GSGNSHSKGGSSCSSNSSSVSGLPG----GDLPTDNIKLEPGTEPQVQP 2187
                            .:||:::...:..|:.||:::..||    ..:.|.|..|...:......
  Rat  1478 LVAPPNQSLVTAPQMTNTGNANAPSATLASAASSTMTLTPGVAISTSVATANSTLTTTSSSSSSS 1542

  Fly  2188 M----ETNEIKQEPGVGKGGT-------AAGETKPTLILG------------------------- 2216
            |    .:|::...|..|...|       |.|.|..:..||                         
  Rat  1543 MSSGVSSNKLPSFPPFGSMNTSGTGSMSAQGSTVQSGQLGGQQSSSLQAAGISGESASLPTQPHP 1607

  Fly  2217 ---------DPLGM---GETLEDINPSAIVLYVVNPFTFAS--DSCELERLALIALLRCYAELLK 2267
                     |.:|:   |::.....|.|||:|:::|||:.:  :|.....:..:.||||:.|:|:
  Rat  1608 DVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTSSSNVWTLGLLRCFLEMLQ 1672

  Fly  2268 AVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIFSQCRRHLVHAQSVKSLTGFGT 2332
            .:|..::|.:::||:..:.:::.....:|:.:|..::.||.:.|:||||.|..:.:||:|||||.
  Rat  1673 TLPPHIKSTVSVQIVPCQYLLQPVKHDDRQIYSQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGP 1737

  Fly  2333 AANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLS 2397
            ...||..||:.|.|  ...::||.||:|||:.::..:      .|...|:...:|:|::..||||
  Rat  1738 GLAMETALKSPDRP--ECIRLYTPPFILAPVKDKQTE------LGETFGEAGQKYNVLFVGYCLS 1794

  Fly  2398 EDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVI 2462
            .||.|:||:.||..||:||...|||||||||||:|..||...|:||.::.:|::..:|..||:||
  Rat  1795 HDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVI 1859

  Fly  2463 GRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSACLVTLEPDAKLRVMP 2525
            ||:|||||.|||.||.|||::.||..||:.||||:.|.:..  .|:|||||||.:||.....:||
  Rat  1860 GRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMP 1924

  Fly  2526 DQFTPDERFSQ---ISMQNP-LATPQDVTCTHILVFPTSAVCAPFTRQFQNEPQVDDDFLTFEEE 2586
            |..:....|.:   ::||.| |.||||.:|||||||||||.....:..:..| .:|   |.|.. 
  Rat  1925 DSVSTGSVFGRSTTLNMQTPQLNTPQDTSCTHILVFPTSASVQVASATYTTE-NLD---LAFNP- 1984

  Fly  2587 GNEDFSDA-------DIGDLFWDTHMDRV---------SNHGSPGRMDDNRSWQSAGGNNFKCTP 2635
             |.|.:|.       |.||   |...|.:         |...|||....:......|....:...
  Rat  1985 -NNDGADGMGIFDLLDTGD---DLDPDIINILPASPTTSPVHSPGSHYPHGGDAGKGQGTDRLLS 2045

  Fly  2636 PQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDI 2700
            .:..:||.::.|||:::||.||||..|.:|.|||||||..:..||:|||.:|||||||:|| |::
  Rat  2046 TESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQS-DEL 2109

  Fly  2701 LNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLY 2761
            |:|.::      ||||||.|:||||||||.|||||||..|....||.|||||:...|..||
  Rat  2110 LHSKHS------HPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLY 2164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
skdNP_730591.2 Med13_N 15..490 CDD:288451 149/501 (30%)
Med13_C 2234..2755 CDD:283892 229/544 (42%)
Med13XP_038941974.1 Med13_N 9..286 CDD:402956 123/397 (31%)
MID_MedPIWI 1366..1721 CDD:408105 92/360 (26%)
Med13_C 1757..2160 CDD:399381 190/424 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166342668
Domainoid 1 1.000 332 1.000 Domainoid score I1102
eggNOG 1 0.900 - - E1_KOG3600
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H21067
Inparanoid 1 1.050 898 1.000 Inparanoid score I365
OMA 1 1.010 - - QHG46046
OrthoDB 1 1.010 - - D177884at2759
OrthoFinder 1 1.000 - - FOG0002706
OrthoInspector 1 1.000 - - otm45333
orthoMCL 1 0.900 - - OOG6_104038
Panther 1 1.100 - - O PTHR48249
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2492
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.860

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