DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment skd and med13

DIOPT Version :9

Sequence 1:	NP_730591.2	Gene:	skd / 43906	FlyBaseID:	FBgn0003415	Length:	2768	Species:	Drosophila melanogaster
Sequence 2:	NP_594050.2	Gene:	med13 / 2542571	PomBaseID:	SPAC589.02c	Length:	1225	Species:	Schizosaccharomyces pombe

Alignment Length:	606	Identity:	99/606 - (16%)
Similarity:	184/606 - (30%)	Gaps:	228/606 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1996 QPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSYFRELSST 2060
            || |.|::.|.:..:|:...:...|....|:||..::|....::...:..|.:...|:|.::...
pombe   742 QP-PRVLLKYNEKKLSLDSSAPENWISLCLQPYGESKDFEVFLLSSKSPDVSSKAISFFYDVQLA 805

  Fly  2061 YEMCKLGKHTPIRGWDGFLQVGAARNNVPADRETTPLDDWLRTLEHAALAEQIRRYAVAFIHQLA 2125
            ||.|||||                                 ..|...::.|::..::
pombe   806 YENCKLGK---------------------------------LNLSETSINERVMGFS-------- 829

  Fly  2126 PYLSRVPNDKTLLNPPDGSGNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMET 2190
                      |.:|..|...::.:....:.:|..                        |:..:..
pombe   830 ----------TNINETDNYDDNETTQSDTATSYE------------------------QLASVCV 860

  Fly  2191 NEIKQEPGVGKGGTAAGETKPTLILGDPLGMGETLEDINPSAIVLYVVNPFTFASDSCELERLAL 2255
            ||:.     ||.                               ||:    |.|..|..|
pombe   861 NELS-----GKN-------------------------------VLF----FYFLEDDSE------ 879

  Fly  2256 IALLRCYAELLKA------VPDSVRSQMNIQIISLESVMELGPCGNRKRFSDE---IRCLALNIF 2311
                    :||||      |.||::              .||.    .:|.|:   |..:..:||
pombe   880 --------KLLKACQHFICVKDSIK--------------RLGD----NKFEDKSLRICTIPNSIF 918

  Fly  2312 SQCRRHLVHAQSVKSLTGFGTAAN----MEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDF 2372
            .....|..::.|..:........|    |:..||.: ||   |: :...|.:....::..|....
pombe   919 DSPNSHTTNSNSFFTKVSLDIYNNDPLLMDGSLKRR-EP---AF-LLKKPLLSTLNYQLKDINPR 978

  Fly  2373 SRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARY 2437
            |.:.|      |:...|.|    .:.::..|:....|..||.                 :...||
pombe   979 SSALG------EYALHVTY----TTVEEHLLICNWNDSYGEF-----------------ETERRY 1016

  Fly  2438 V--------ALKKLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQ-------- 2486
            .        ||:::::.....::.....|.:::.:||.:..:|...|...:..:.||
pombe  1017 FLQDLEIEDALQQILEVTFTFLNSMHMDWIVIVMKIGEMSDAEYLFWDQAIIPENLQGNVSLTVG 1081

  Fly  2487 ---------KASKQFKDM--CKQCTLMYPPTILSACLVTLEPDAKLRVMPDQFTPDERFSQISMQ 2540
                     ..||.|..:  ....|::...:.....||....:..:.|..|:|   ::.|.|..:
pombe  1082 YCSAEHGPGSTSKVFSRIPYSASSTVIRNNSSHELSLVAFIREMAMPVPNDEF---KKISTILAR 1143

  Fly  2541 NPLATPQD-----VTCTHILV 2556
            ..||..:|     :...|:|:
pombe  1144 GYLALDEDESYLPLLSIHLLI 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451
skd	NP_730591.2	Med13_C	2234..2755	CDD:283892	67/368 (18%)
med13	NP_594050.2	Med13_C	<944..>1080	CDD:283892	28/167 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100