DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment skd and MED13L

DIOPT Version :9

Sequence 1:	NP_730591.2	Gene:	skd / 43906	FlyBaseID:	FBgn0003415	Length:	2768	Species:	Drosophila melanogaster
Sequence 2:	XP_011536382.1	Gene:	MED13L / 23389	HGNCID:	22962	Length:	2222	Species:	Homo sapiens

Alignment Length:	2970	Identity:	790/2970 - (26%)
Similarity:	1195/2970 - (40%)	Gaps:	973/2970 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NHQTNGASLEDCHTNFYALTDLCGIKWRKFVNGER----PNASSDPLADPILRSYSRCIQADMLC 65
            |...|||||||||:|.::|.:|.|||||::..|..    |..|:....||||.|:.||:||::||
Human     6 NWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLC 70

  Fly    66 VWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAAN 130
            ||||  ..|.|                         .|||||||:|:||:|..::..||
Human    71 VWRR--DVKPD-------------------------CKELWIFWWGDEPNLVGVIHHEL------ 102

  Fly   131 QALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFS 195
            |.:..|.|:..|:||||:|||||:|||:||.::.|:.||.|||||:|....::...: |:|||.:
Human   103 QVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNK-SEHLSCA 166

  Fly   196 FTFFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDP 259
            ||||:||:: ||.|:::.:|..:..:.:||:
Human   167 FTFFLHGESNVCTSVEIAQHQPIYLINEEHI---------------------------------- 197

  Fly   260 NGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPLCNK 324
                        ..|:::|.|.  :|:::|:|:.|.|||.:||.|||...|::|:|..|:|:..|
Human   198 ------------HMAQSSPAPF--QVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLK 248

  Fly   325 D------------NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAA 377
            .            :.|.|..|||:.||.:|.:|:.:||::..|          ..:..|||.|..
Human   249 KKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQND----------IPVPQSVASAGG 303

  Fly   378 ESAVLASLSCPPGAASAPSSMGAA--PSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAA 440
            ..||            ....:|:.  ||...:||.|.:....|:.|.. |...|:|:..:|:...
Human   304 HIAV------------GQQGLGSVKDPSNCGMPLTPPTSPEQAILGES-GGMQSAASHLVSQDGG 355

  Fly   441 PQAVSALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAV 505
            ...:.:.:|            ||        .||......|..|.|::|::|......:..:...
Human   356 MITMHSPKR------------SG--------KIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPT 400

  Fly   506 ASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNAQCN 570
            ....|||...:                                  |:||||.|:..|.|:..:..
Human   401 LEEEPASNPAT----------------------------------WDFVDPTQRVSCSCSRHKLL 431

  Fly   571 SSSSISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQHYHQQHLQQQ 635
            ...::.       |.:|   |.:  :..|.|...|||||....:||...::.:|:.      ..:
Human   432 KRCAVG-------PNRP---PTV--SQPGFSAGPSSSSSLPPPASSKHKTAERQEK------GDK 478

  Fly   636 QQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSLASTASSTASTFRA 700
            .|:||                                   .:|||.|     .|.|....
Human   479 LQKRP-----------------------------------LIPFHHR-----PSVAEELC----- 498

  Fly   701 KNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGG-DSSMPVASVESPATPAPSPHPNSA 764
                   .:.:.|.|: ||                  |.| |||:.|:|..........|..|:
Human   499 -------MEQDTPGQK-LG------------------LAGIDSSLEVSSSRKYDKQMAVPSRNT- 536

  Fly   765 HSQPTSVPPAEQLLNMSPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQT 829
             |:..::.|.:     |||:|.|       |.|       .|.:|.|..|             :|
Human   537 -SKQMNLNPMD-----SPHSPIS-------PLP-------PTLSPQPRGQ-------------ET 568

  Fly   830 PSVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPAT------------PTAATSAGGAGSGG-- 880
            .|::|||.        |......|.|   :..||.:|            |..|..:..|...|
Human   569 ESLDPPSV--------PVNPALYGNG---LELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIR 622

  Fly   881 PSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGG---VTSTTEALNNFKRLYNPP 942
            |||        ..|.:|.....:.|.:..|..:.|..||.....   |.|.:.||   :||...|
Human   623 PSN--------PESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTAL---QRLLAQP 676

  Fly   943 KLTLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPR-----YAKNLYEGQNHVKP 1002
            .                                 ||.|:.:.::|:     :...|        |
Human   677 N---------------------------------KRFKIWQDKQPQLQPLHFLDPL--------P 700

  Fly  1003 VMPSPGSVYG-------------SQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSD 1054
            :...||...|             ..:.:.::...|...:....:.....|.|...:  :|...|.
Human   701 LSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDV--TTPGHST 763

  Fly  1055 VEADGSSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFE 1119
            ...||         |....:.|.:.|...:.   :::.|.:|| .:|.....|.|||:||:.:|:
Human   764 PVPDG---------KNAMSIFSSATKTDVRQ---DNAAGRAGS-SSLTQVTDLAPSLHDLDNIFD 815

  Fly  1120 TSSNDECSSVQIHTPP--DSNNPSNGGCSAVTNTIED--LKRSTAVASAAVAAAAAAAASGAGNI 1180
            .|.:||..:|   :|.  .|..|:.|        .||  |.:.   ..|||......|
Human   816 NSDDDELGAV---SPALRSSKMPAVG--------TEDRPLGKD---GRAAVPYPPTVA------- 859

  Fly  1181 QAEDLTKMFPTPPSHEQQHPNSSPCQTDVVMT---DLSVDTTTTIITSSITTTCNTTITSSINTT 1242
               ||.:|||||||.| |||..||     ||.   .:|.:|.|.
Human   860 ---DLQRMFPTPPSLE-QHPAFSP-----VMNYKDGISSETVTA--------------------- 894

  Fly  1243 TTACSNPSNSIMLAAAQAP-VTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFV 1306
                        |...::| |::|:.|...  .|.|....||||..|.|.|:.||::.|..:.||
Human   895 ------------LGMMESPMVSMVSTQLTE--FKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFV 945

  Fly  1307 GSTRYAPLTNLPSQTQPPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLH 1371
            ||:.:|||..|||....||.:|..|.::|:|:.
Human   946 GSSMFAPLKMLPSHCLLPLKIPDACLFRPSWAI-------------------------------- 978

  Fly  1372 QQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPSTVPQPLSSGGS 1436
            ..|::||.:         ..||.....|.                        :.||...|....
Human   979 PPKIEQLPM---------PPAATFIRDGY------------------------NNVPSVGSLADP 1010

  Fly  1437 QYL-LNQLNCP----QAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHPPPP--- 1493
            .|| ..|:|.|    .|.|.::     ..||:.|       .|...|.|..:..||..|..|
Human  1011 DYLNTPQMNTPVTLNSAAPASN-----SGAGVLP-------SPATPRFSVPTPRTPRTPRTPRGG 1063

  Fly  1494 --------YPYDLA-VASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAY 1549
                    ..||.. ..|||::.|:  .|||:|.|
Human  1064 GTASGQGSVKYDSTDQGSPASTPST--TRPLNSVE------------------------------ 1096

  Fly  1550 TGDAGIVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIG 1614
                             .:.:|.:||.:|:.|.::|.|:.:|:|:|.||||..:|.||.
Human  1097 -----------------PATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNM------ 1138

  Fly  1615 NIRGADSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAG 1679
            ||:|||.|:|:
Human  1139 NIKGADVGLYI------------------------------------------------------ 1149

  Fly  1680 SGHGHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGI 1744
                             |.|||        :|...|||||||::||:|.:.:|||.|||::|.|.
Human  1150 -----------------PDSSN--------EDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGK 1189

  Fly  1745 ADDPGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCS 1809
            ..|.|:..:..|:....:...:.:..:.|.|...:|                      |||
Human  1190 NSDIGQAAERRLMMCQSTFLPQVEGTKKPQEPPISL----------------------LLL---- 1228

  Fly  1810 IIQTSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANVLEFMDAHDVISL---------- 1864
                        ||:...:             |.|||    |.|:::.:::..:|
Human  1229 ------------LQNQHTQ-------------PFASL----NFLDYISSNNRQTLPCVSWSYDRV 1264

  Fly  1865 -------------ALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIG 1916
                         ||||.|     |.:||.                 |........:|
Human  1265 QADNNDYWTECFNALEQGR-----QYVDNP-----------------TGGKVDEALVR------- 1300

  Fly  1917 AGRLTVHKWPY---LPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLT 1978
              ..|||.||:   |.:... |::::||.:.::||.||:|...|..|    :...:...|.||||
Human  1301 --SATVHSWPHSNVLDISML-SSQDVVRMLLSLQPFLQDAIQKKRTG----RTWENIQHVQGPLT 1358

  Fly  1979 WRQFHRLAGR----ASGQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVV 2039
            |:|||::|||    :....||.|||:::|||:||:::::|.|:.:|::.||:||...|||.|:||
Human  1359 WQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVV 1423

  Fly  2040 CPDNEHVVNCTRSYFRELSSTYEMCKLGKHTPI----RGWDGFLQVGAARNNVPADRETTPL-DD 2099
            ||:||.::...:::||:||:.||||:||:|.||    |  ||.::||    ...|.:.|..| .:
Human  1424 CPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLR--DGIMRVG----KTVAQKLTDELVSE 1482

  Fly  2100 WLR---TLEHAALAEQIRRYAVAFIHQLAPYLSRVPNDKTLLNP--------------------- 2140
            |..   :.|......:::.||....|.|||||:.:..|.:||.|
Human  1483 WFNQPWSGEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGP 1547

  Fly  2141 --PDGS-----GNSHSKGGSSCSSNSSSVSGLPGGDLPTDNIKLEPGTEPQVQPMETNEIK---- 2194
              |:||     |::.:...:|.|:|.::.|...|..:|..:   ...:.|.:..:.|....
Human  1548 LAPNGSAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVS---SSASAPGISQISTTSSSGFSG 1609

  Fly  2195 ----QEPGVGKGGTAA----------GETKPTLILGDPLGMGE------------TLED-----I 2228
                |.|..  ||.:|          |:|.|......|...|:            |..|     .
Human  1610 SVGGQNPST--GGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSADSHA 1672

  Fly  2229 NPSAIVLYVVNPFTFASDSCELE-RLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGP 2292
            :|.|:|:|:|:|||:|::..... ...|::|:|||.|:|..:|:.:|:...:||:..:.:::
Human  1673 HPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQ--- 1734

  Fly  2293 CGNRKRFSDE-------IRCLALNIFSQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRA 2350
                 ...||       ::.:|.:::.||||.|.....:|||||||.||::|..||..:.|:  .
Human  1735 -----TMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPS--P 1792

  Fly  2351 YKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEML 2415
            .::|:.||:|||:.::..:      .|...|:...:|:|::..||||.||.||||:.||..||:|
Human  1793 IQLYSPPFILAPIKDKQTE------LGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELL 1851

  Fly  2416 EKICINIDVPN------------RARRRKAPARYVALKKLMDFIMGIISQTSQMWRLVIGRIGRI 2468
            |...:||.:||            |:||.|..||.:.|:||.::.:||:..||..||:||||:||:
Human  1852 ETCVVNIALPNRDPFPFPISLFVRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRL 1916

  Fly  2469 GHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSACLVTLEPDAKLRVMPDQFTPD 2531
            ||.|||.||.||.:..||..||:.||:|:.|.:..  .|:|||||||.:||.....||||..|..
Human  1917 GHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMG 1981

  Fly  2532 ERFSQ---ISMQ-NPLATPQDVTCTHILVFPTSAVCAPFTRQFQNE----PQVDDDF--LTFEEE 2586
            ..|.:   ::|| :.|.||||.:||||||||||:........:.||    |..||.|  |.|.::
Human  1982 SVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDD 2046

  Fly  2587 GNEDFSDADIGDLFWDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPIS 2651
            .:.|......|:|....:...|.:.|||..:.....:|.:.....:....:..||   |.|||::
Human  2047 MDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEE---LKQQPLA 2108

  Fly  2652 VGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLD 2716
            :||.||||....:|.||||:||..::.||:|||.:||.|: |:...|::|.:.|:.:.  .||||
Human  2109 LGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHI-SVAQTDELLPARNSQRV--PHPLD 2170

  Fly  2717 SNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLY 2761
            |..|:||||||||.|||||||..:..|.||.||||::...|..||
Human  2171 SKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLY 2215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	146/493 (30%)
skd	NP_730591.2	Med13_C	2234..2755	CDD:283892	215/552 (39%)
MED13L	XP_011536382.1	Med13_N	16..385	CDD:288451	146/493 (30%)
MED13L	XP_011536382.1	Med13_C	1678..2209	CDD:283892	215/552 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148775
Domainoid	1	1.000	331	1.000	Domainoid score	I1145
eggNOG	1	0.900	-	-		E1_KOG3600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	910	1.000	Inparanoid score	I366
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46046
OrthoDB	1	1.010	-	-		D177884at2759
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	1	1.000	-	-		otm41196
orthoMCL	1	0.900	-	-		OOG6_104038
Panther	1	1.100	-	-	LDO	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860