Protein Alignment skd and med13l

DIOPT Version :9

• Sequence 1: NP_730591.2
• Gene: skd / 43906
• FlyBaseID: FBgn0003415
• Length: 2768
• Species: Drosophila melanogaster
• Sequence 2: XP_002939237.3
• Gene: med13l / 100491622
• XenbaseID: XB-GENE-6045769
• Length: 2136
• Species: Xenopus tropicalis
• Alignment Length: 2922
• Identity: 797/2922 - (27%)
• Similarity: 1166/2922 - (39%)
• Gaps: 963/2922 - (32%)

  Fly     5 NHQTNGASLEDCHTNFYALTDLCGIKWRKF---VNGE-RPNASSDPLADPILRSYSRCIQADMLC 65
            |...|||||||||:|.::|.:|.|||||::   ..|| .|..|:....||||.|:.||:||::||
 Frog     6 NWAANGASLEDCHSNLFSLAELTGIKWRRYRYQGPGECGPVISAPAQDDPILLSFIRCLQANLLC 70

  Fly    66 VWRRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAAN 130
            ||||  ..|.|.                         |||||||:|:||:|.:::..||
 Frog    71 VWRR--EVKPDR-------------------------KELWIFWWGDEPNLGDVIHHEL------ 102

  Fly   131 QALWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFS 195
            .....|.|:..|:||||:|||||:|||:||.:|.|:.||.|||||:||...::...: |::||.|
 Frog   103 HMDEEGFWENGLSYECRTLLFKAIHNLLERCLLDKNFVRIGKWFVKPCEKEEKSLSK-SENLSCS 166

  Fly   196 FTFFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDP 259
            ||||:||:: ||.|:::.:|..|..:.::||..|..:.|..
 Frog   167 FTFFLHGESNVCTSVEIAQHQPVYLINQQHLHLAQTSHAPC------------------------ 207

  Fly   260 NGASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL--- 321
                                    :|:|:|:|::|.|||:.||.|||...|:||:|..|:|.
 Frog   208 ------------------------QVILSPYGLSGTLTGHGYKTSDPTTRKLLEEWRPFYPTVLR 248

  Fly   322 CNKD-------NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAES 379
            ..:|       |.|.|..|||:.||.::.:|:.:||:...|          ..:.|||.||...|
 Frog   249 VRQDQQEELQYNDDFPAAVEVIVGGVRLVYPSAFVLIAQSD----------LPLSSSVGGAGHSS 303

  Fly   380 AVLASLSCPPGAASAPSSMGAAPSATAVPLGPASLNAPALAGAGVGATASSAAKEISRKAAPQAV 444
            .  ....|        :::...||...:||.|.:  :|.....|.|....|:   |:..:....|
 Frog   304 T--GGQQC--------TAVTKDPSPCRMPLTPPT--SPEQIAPGDGKENPSS---INSHSTEDGV 353

  Fly   445 SALERLAFQPYYDQRPTSGFTFNTNNTHIPASAAVEMPERTWQDCVMNTLHVDAAAAAAAVASST 509
            |             .|.........:.|..:|   .|.:|.|::|::|..
 Frog   354 S-------------NPKQSSKCGEKSCHRLSS---YMAQRVWKECIVNRC--------------- 387

  Fly   510 PASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNAQCNSSSS 574
                            |.|....|:|..:.||.:..     |:||||..:|.|.|
 Frog   388 ----------------QPKLTVSSQQEGEIQISKAP-----WDFVDPTHRATCSC---------- 421

  Fly   575 ISNISNNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQHYHQQHLQQQQQQR 639
                |.:|..:|       |:|.:|...:..:..:.....:|.|||
 Frog   422 ----SRHKYSKQ-------RSAPSGSRPSSVTQPNMGGIPTSCSSS------------------- 456

  Fly   640 PGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSLASTASSTASTFRAKNHS 704
                 ||..|  ||.|..    |.....:....::...|||.|.|              ..:|..
 Frog   457 -----LPPPA--SSKHKP----TDRQEKAEKLQKKTTTPFHHRAL--------------PIQNEQ 496

  Fly   705 NTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPSPHPNSAHSQPT 769
            ..|.:|.|.:::            ||..                    ||..|   ||..:....
 Frog   497 CLTQETAIQQRQ------------GAEA--------------------ATSTP---PNRQYQSMP 526

  Fly   770 SVPPAEQLLNM----SPHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSITASPYVHQTP 830
            |....:|||..    |||:|.|    ..||          |.:|.|..|.     .|.|    .|
 Frog   527 SAGELDQLLTSQPSDSPHSPAS----PMPP----------TLSPQPPQQE-----VAIP----DP 568

  Fly   831 SVEPPSYTDHAAGGGPAGGQGLGTGPGSVPAQQPATPTAATSAGGAGSGGPSNAIGANAVGTISV 895
            .|:|.:.|.:               |..:..|    |....:...||.|.|..|..:..  :|..
 Frog   569 EVQPCNSTLY---------------PNGLEMQ----PLDDRTMMAAGLGLPLMAELSET--SIYC 612

  Fly   896 KKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNNFKRLYNPPKLTLKDPDSFYDEEWLKE 960
            ..|...|||.::    .||......|              ...:.||.:.:         ||.:.
 Frog   613 SSLSQSQQTENS----WQEYMLPSTG--------------NEDFRPPNIPV---------EWHES 650

  Fly   961 VIYDFQYQEYWDYSTV---------KRPKMEKQRRPRYAKN--------LYEGQ--NHVKPVMPS 1006
            :      ||..|.||.         ||.|:..:.||..:.|        :|..|  :::.|....
 Frog   651 I------QETGDDSTALERLLAQPNKRFKVLDENRPILSDNRTYLDQPPMYLEQLGDNLDPYTFE 709

  Fly  1007 PGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADGSSFFQGLNIKTE 1071
            .|.:..|  .:..:.......|               .::....:....|.:.|...|..:: |:
 Frog   710 DGEIKYS--FTATKKCKMGAER---------------DLSRKLKADEGFEKNASPTEQPASV-TD 756

  Fly  1072 PG-----LHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSNDECSSVQI 1131
            ||     :.||:.|...:..        .|...:|...:.|.||||||:.||:.|.:::.
 Frog   757 PGKNVMSIFSPASKPDPRQD--------RGIAASLTQVKDLAPSLNDLDNLFDNSEDEDL----- 808

  Fly  1132 HTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGNIQAEDLTKMFPTPPSHE 1196
                 :.:|......|.:...||    .|:...|..|.|.:|.         ||.:|||||||.|
 Frog   809 -----AGSPGTRAMKAPSVGSED----RALGKDARTAVAYSAT---------DLQRMFPTPPSLE 855

  Fly  1197 QQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSNPSNSIMLAAAQAP 1261
             |||..||..  :....:|.:||.|                                 ||..::|
 Frog   856 -QHPAFSPIM--IYKDGVSSETTAT---------------------------------LAMMESP 884

  Fly  1262 VTVVAIQTVSKMVKQEYNLE----LGSPMEEPINDWDYVYRPPQQEKFVGSTRYAPLTNLPSQTQ 1322
            :.     .::.|...|:.:|    |.||..|.|.|:.||:|....:.|||::.:|||.:||||..
 Frog   885 MV-----NLASMHHLEFKMEVEEGLCSPKPEEIRDFSYVHRVASSQPFVGTSMFAPLKSLPSQCL 944

  Fly  1323 PPLTLPTGCFYQPTWSSHKSRAATLAKAAAAQQQQHQKHQALQQRIQLHQQKLQQLQLQNQQQQQ 1387
            ..|.:|..|.|:|:|             ||..:.||
 Frog   945 LSLKIPDACVYRPSW-------------AAPPKMQH----------------------------- 967

  Fly  1388 AAAAAAAAASGGVGHQKHQHQHLHDLLSAAPRTPLTPST---------VPQPLSSGGSQYLLNQL 1443
                                            .||.|:|         ||...|.....||  ||
 Frog   968 --------------------------------LPLPPATSFNRDGYMNVPSVGSLTDPDYL--QL 998

  Fly  1444 NCPQAPPGASMQQLMHRAGMSPISPGP----GMG-----PYAARSSPMSRATPTHPPPP------ 1493
            |.||.           ...::|.|..|    |.|     |...|.|..:..||..|..|
 Frog   999 NTPQT-----------NTPLAPCSTAPASNSGTGGVLPSPATPRFSVPTPRTPRTPRTPRGGGGA 1052

  Fly  1494 -----YPYDLA-VASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGD 1552
                 ..||.. :.|||::.|:  .|||.|.|....|
 Frog  1053 SGQGSAKYDSTDLCSPASTPST--TRPLSSVEPASSH---------------------------- 1087

  Fly  1553 AGIVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIR 1617
                               ..||.:|:.|.:||.|:.||:|:|.||||..:|.||.      ||:
 Frog  1088 -------------------PAPEAHSLYVTLLLSDSVLNIFKDRNFDSCCICACNL------NIK 1127

  Fly  1618 GADSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGH 1682
            |||.|:|:
 Frog  1128 GADVGIYI--------------------------------------------------------- 1135

  Fly  1683 GHGPNGGSNSSSCTPPSSNPHITGYVDDDPVECTCGFSAVVNRRLSHRAGLFYEDEVEITGIADD 1747
                          |.|||        :|...|||||||:|||||.:.:|||.|||::|.|.:.|
 Frog  1136 --------------PDSSN--------EDQYRCTCGFSAIVNRRLGYNSGLFIEDEMDIFGRSSD 1178

  Fly  1748 PGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQLEQLGHAVFDLLLDQCSIIQ 1812
            .|:..:..|  .|:...|..|.:..||                         :..||..||:
 Frog  1179 LGQAVERRL--NIRVTERLGQEQPPPG-------------------------LLLLLQRQCT--- 1213

  Fly  1813 TSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANV--------------LEFMDAHDVIS 1863
                                 |.| ||.:.|..|:....|              .|..||.....
 Frog  1214 ---------------------RPF-NNCSSTWELSYCQGVSLLDRPSWNYDRVRAESSDAWPECL 1256

  Fly  1864 LALEQSRLAFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPY- 1927
            .||||.|     |.:||                        |...|...|.:.:.  |.|.||:
 Frog  1257 NALEQGR-----QYVDN------------------------PTGGRVDEALVKSA--TFHLWPHS 1290

  Fly  1928 --LPVGFTRSNKEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRAS 1990
              |.|....| :::||.:.::||.||:|...|..|    :...:...|.|||||:|||::|||.|
 Frog  1291 NVLDVSMLPS-QDVVRMLLSLQPFLQDAIQKKRTG----RTWENIQHVQGPLTWQQFHKMAGRGS 1350

  Fly  1991 ----GQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTR 2051
                ...||.|||:::|||:||::::||.|:.:|::.|||||...|||.|:|:||:|..:::..:
 Frog  1351 YGSEESPEPLPIPNLLVGYDKDFLTIAPFSLPFWERLLLEPYGGQRDVGYLVLCPENSALLDGAK 1415

  Fly  2052 SYFRELSSTYEMCKLGKHTPIRG--WDGFLQVGAARNNVPA-DRETTPLDDWLRTLEHAALAEQI 2113
            ::||:||:.||||:||:|.||..  .||.:::     :.|| |.|.|..::    :::.|   ::
 Frog  1416 AFFRDLSAVYEMCRLGEHRPICKVLSDGIMKI-----SQPAGDSEETSCEE----MDNQA---RL 1468

  Fly  2114 RRYAVAFIHQLAPYLSRVPNDKTLLNPPDGS----GNSHSKGGSSC--------SSNSSSVSGLP 2166
            :.:|......||||||.:..|.:||.||...    ..|.|....||        :.|.:|.:.||
 Frog  1469 QLFAQTCRQHLAPYLSTLQLDSSLLLPPKNQPPTVQTSSSPAVPSCPTGVLFNTTPNGTSTTPLP 1533

  Fly  2167 ------GGDLPTDNIKLEPGTEPQVQPMETNEIKQEPGVGKGGTAAGETKPTLILGDPLGMGETL 2225
                  ...||..|..:..|.. ......|:.|.:.| :|...|           |||....:::
 Frog  1534 PPPLSSSTSLPAGNSTVPTGFN-NCPSQNTSSIVERP-LGNQTT-----------GDPEPSQQSM 1585

  Fly  2226 EDINPS------------------------AIVLYVVNPFTFASD-SCELERLALIALLRCYAEL 2265
            :...|.                        .:|:|:|:|||:..| .|......::.|:||:.::
 Frog  1586 QQETPENATEREKIGIPTEPEPAGALSSCPTVVIYMVDPFTYTVDEDCHPGNYWMLGLIRCFTDM 1650

  Fly  2266 LKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEI-------RCLALNIFSQCRRHLVHAQS 2323
            |:::|:.:||...:|::...|:::        ..:||:       :.||.:::.||||.:.....
 Frog  1651 LESLPEPLRSACILQVVPCHSLLQ--------TVNDEVVSYIQHLKSLAFSVYCQCRRPIATQIP 1707

  Fly  2324 VKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSAGSMHGQNEHRYS 2388
            :|.|||||.||.:.|.|:.:::|:  ..:||:.||:|:|..::..:      .|...|:...:|:
 Frog  1708 IKPLTGFGPAAALNAILRNQEQPS--PGQMYSPPFLLSPTKDKQTE------LGETFGEAGQKYN 1764

  Fly  2389 VMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALKKLMDFIMGIISQ 2453
            |::..||||.||.||||:.||.:||:||...:||.||||.||.|..||.:.|:||.::.:.||..
 Frog  1765 VLFVGYCLSHDQRWLLASCTDLQGELLETCVVNIHVPNRFRRSKVSARKIGLQKLWEWCVEIIQT 1829

  Fly  2454 TSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--PPTILSACLVTLE 2516
            ||..||:||||:||:||.|||.||.||.:..||..|:|.|:.||.|.:..  .|:|||||||.:|
 Frog  1830 TSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISRQLKETCKMCGISAADSPSILSACLVAME 1894

  Fly  2517 PDAKLRVMPDQFTPDERFSQISMQN----PLATPQDVTCTHILVFPTSAVCAPFTRQFQNE-PQV 2576
            |.....||||..|....|.:.:..|    .|:||||.:|||||||||||........:.|| ..:
 Frog  1895 PQGSFTVMPDAVTMGSVFGRSTALNLQTSQLSTPQDASCTHILVFPTSATIQVSPANYHNEDDML 1959

  Fly  2577 DDDFLTFEEEGNEDFSDADIGDLF-WDTHMDRVSNHGSPGRMDDNRSWQSAGGNNFKCTPPQEVE 2640
            |..||        |..|.|||.|. .:.|....|:.|||          :..|.:|:.:..| ||
 Frog  1960 DLPFL--------DDMDNDIGILITGNLHSPPNSSPGSP----------TGAGPHFQHSRSQ-VE 2005

  Fly  2641 EVGS------LNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDVCPVFLKTALHLHVPSIQSADD 2699
            .:.|      |.|||:::||.||||....:|.||||:|||.::.||:|||.:||.|: |:...||
 Frog  2006 RLLSRETPEELKQQPLALGYYVSTAKAENLPEWFWSSCPHAQNQCPLFLKASLHHHI-SVSHNDD 2069

  Fly  2700 ILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNTHDRLSCLPINVQTLMDLY 2761
            ::.:..:.:.  .|||||..|:||||||||.|||||||..:..|.||.||||::...|..:|
 Frog  2070 LVPARTSQRV--PHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFTVLTQMY 2129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	149/489 (30%)
		Med13_C	2234..2755	CDD:283892	217/542 (40%)
med13l	XP_002939237.3	Med13_N	13..247	CDD:402956	114/315 (36%)
		VirB10_like	422..>586	CDD:421703	56/291 (19%)
		MID_MedPIWI	1396..1700	CDD:408105	85/336 (25%)
		PHA03255	<1495..>1606	CDD:165513	23/123 (19%)
		Med13_C	1736..2125	CDD:399381	180/416 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1124
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	900	1.000	Inparanoid score	I378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177884at2759
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	1	1.000	-	-		otm48409
Panther	1	1.100	-	-	LDO	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2492
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160