Protein Alignment skd and med13

DIOPT Version :9

• Sequence 1: NP_730591.2
• Gene: skd / 43906
• FlyBaseID: FBgn0003415
• Length: 2768
• Species: Drosophila melanogaster
• Sequence 2: XP_004911678.1
• Gene: med13 / 100490132
• XenbaseID: XB-GENE-1000947
• Length: 2171
• Species: Xenopus tropicalis
• Alignment Length: 2943
• Identity: 780/2943 - (26%)
• Similarity: 1198/2943 - (40%)
• Gaps: 976/2943 - (33%)

  Fly     9 NGASLEDCHTNFYALTDLCGIKWRKFVNGERPNASSDPL------ADPILRSYSRCIQADMLCVW 67
            |||||||||:|.:.|.||.||||:::: .:.|  :|.|:      .||||.|:|||::||:|.||
 Frog     8 NGASLEDCHSNLFCLADLTGIKWKRYI-WQGP--TSAPILFPVTEEDPILSSFSRCLKADVLSVW 69

  Fly    68 RRVQSTKTDHADPNALTFEMTTSTKVHPPLSLAAAKELWIFWYGEEPDLSELVDAELLRVAANQA 132
            ||.:.                           ...:||||||:||:|:.::|:..:|    |::.
 Frog    70 RRDER---------------------------PGRRELWIFWWGEDPNFADLIHHDL----ADEE 103

  Fly   133 LWNGTWKGALTYECRSLLFKALHNLMERFVLTKDIVRFGKWFVQPCTSSDRLFGRSSQHLSFSFT 197
              :|.|...|:||||:|||||:|||:||.::.::.||.|||||:|....::...: |:|||.||.
 Frog   104 --DGIWDNGLSYECRTLLFKAIHNLLERCLMNRNFVRIGKWFVKPYEKDEKPVNK-SEHLSCSFA 165

  Fly   198 FFVHGDT-VCASIDLREHPAVRPLTKEHLTEAAAAFAAASSPPGSNGSAASAGGAVPNPGQDPNG 261
            ||:|||: ||.|:::.:|..|..|::||||     .|..|:.|
 Frog   166 FFLHGDSNVCTSVEINQHQPVYLLSEEHLT-----LAQQSNSP---------------------- 203

  Fly   262 ASMDGLDGGEGAAKAAPPPHARKVMLAPFGIAGILTGNSYKASDPIAEKILEDWASFFPL----- 321
                                 .:|:|:|||:.|.|||.|:|.||...:|::.:|..|:|:
 Frog   204 ---------------------FQVILSPFGLNGTLTGQSFKMSDSSTKKLIGEWKQFYPISSSVK 247

  Fly   322 -CNKD-------NTDVPPVVEVVSGGHKMYHPTNYVLVTDLDDMEHMEFVEMQKMQSSVAGAAAE 378
             |:::       ..|....|||:..|.:|.:|..:|||
 Frog   248 ECSEEKQEDMDWEDDSLAAVEVLVAGVRMVYPACFVLV--------------------------- 285

  Fly   379 SAVLASLSCPPGAASAPSSMGAAPSATAVPLG---PASLNAPALAGAGVGATASSAAKEISRKAA 440
                     |.....|.||:|::..:... ||   |||...||:  :.|..|..::.:|: :..:
 Frog   286 ---------PQSDLPAASSVGSSHCSNTC-LGVQVPASSRDPAM--SSVTLTPPTSPEEV-QTGS 337

  Fly   441 PQAVSALERLAFQPYYDQRPTSGFTFNTNNTH---IPASAAVEMPERTWQDCVMNTLHVDAAAAA 502
            ..|.||.:.:.|....|     .|:.:|.:.|   ||...|.::.:|.||:|.||
 Frog   338 IDAQSAQKWVKFPAVSD-----CFSSDTTSHHGGKIPRKLANQVVDRVWQECNMN---------- 387

  Fly   503 AAVASSTPASGTGSLSADGDENEQNKPPQDSKQLVQQQIQQQQQRQKLWNFVDPMQKAPCICTNA 567
                                 ..|||....|..:|.:  .:..::...|:||:..|:..|:|
 Frog   388 ---------------------RAQNKRKYSSNGVVCE--DESPEKTASWDFVESTQRTTCVC--- 426

  Fly   568 QCNSSSSISNIS--NNKRPQQPLGSPALRAAVTGGSGNKSSSSSSSSSSSSSSSSSYQQQH--YH 628
                 |...|:.  |..:|.||:                          ::|:.....|:|  ..
 Frog   427 -----SRHKNLKQRNLNQPGQPV--------------------------TASTQQQVTQKHKTND 460

  Fly   629 QQHLQQQQQQRPGTPVLPATAATSSHHSSSLSNTSASNSSAATPRRHNVPFHKRLLHSLASTASS 693
            :|....:.|:||.||.         ||.:|:|:.....:.:|:.|             |...:..
 Frog   461 KQEKGDKPQKRPLTPF---------HHRASISDDVNIEADSASQR-------------LGIRSQD 503

  Fly   694 TASTFRAKNHSNTTTDTNIPKQRHLGNTPHGTPHGGASTYSRNSLGGDSSMPVASVESPATPAPS 758
            |...|     ||..|: ::.|...:.|               |.:          ..||..|..|
 Frog   504 TRGRF-----SNIRTN-DVAKTPQMHN---------------NEM----------ASSPPPPPLS 537

  Fly   759 PHPNSAHSQPTSVPPAEQLLNMS-PHAPTSVSNLQQPPTPIDHLLDKNTPAPTPTDQHDSKSIT- 821
            |||......     ..|.:.|.| ||:    .:..|.|||     |...|..:..::.|....|
 Frog   538 PHPCEVMDD-----GGETMKNPSTPHS----QHFYQMPTP-----DPLIPVKSIDERIDGLPQTF 588

  Fly   822 ASPYVHQTPSV-EPPSYTDHAAGGGPAGGQGLGTGPG-------SVPAQQ------PATPTAATS 872
            ||.:    |.| ||..|..:|.        .|..|..       .||.::      |..|.....
 Frog   589 ASAF----PEVLEPTMYVGNAV--------RLEAGETDNSWKYYKVPKKKEAEFNPPQLPNDKLR 641

  Fly   873 AGGAGSGGPSNAIGANAVGTISVKKLEMQQQTPSAAMAIKQEPGAQGRGVGGVTSTTEALNNF-- 935
            ....|:.|..|        .:||.:|.:|.:.|                   :..:.|.|:.:
 Frog   642 EDACGTYGKEN--------IMSVTELMVQGKKP-------------------LKISEELLHKYQS 679

  Fly   936 KRLYNPPKL----TLKDPDSFYDEEWLKEVIYDFQYQEYWDYSTVKRPKMEKQRRPRYAKNLYEG 996
            |..|.|..:    ...||.:|.|::      .:|.:.:         .|.|:|...|.....::.
 Frog   680 KNQYIPTAVLDTDQESDPYTFVDDD------VEFIFSD---------TKKERQITDRDVGKKHKA 729

  Fly   997 QNHVK--PVMPSPGSVYGSQLLSLDESASQAGGRGGGGQAAGSSGGGLVGIANSTASGSDVEADG 1059
            ::.:.  .|:|..|.                                                |.
 Frog   730 EDVMSSVTVLPQEGE------------------------------------------------DA 746

  Fly  1060 SSFFQGLNIKTEPGLHSPSCKETSKSSGGNSSGGGSGSGGNLFTAEGLNPSLNDLEQLFETSSND 1124
            .|.|            |||.|..::.|..::....:    :||....|..|..||:.|| .|..|
 Frog   747 MSLF------------SPSVKPDAQRSEAHARTAST----SLFHETDLVVSYTDLDNLF-NSDED 794

  Fly  1125 ECSSVQIHTPPDSNNPSNGGCSAVTNTIEDLKRSTAVASAAVAAAAAAAASGAGN------IQAE 1183
            |.      ||         |.....|..|               .|.:..|..||      |...
 Frog   795 EL------TP---------GSKRALNPDE---------------KANSKESKPGNLDPLSCISTA 829

  Fly  1184 DLTKMFPTPPSHEQQHPNSSPCQTDVVMTDLSVDTTTTIITSSITTTCNTTITSSINTTTTACSN 1248
            ||.||:|||||.||.....||..                :.|......:||...|:...:..|
 Frog   830 DLHKMYPTPPSLEQHFMGFSPMN----------------MNSKDYGNMDTTPGGSLTDGSNFC-- 876

  Fly  1249 PSNSIMLAAAQAPVTVVAIQTVSKMVKQEYNLELGSPMEEPINDWDYVYRPPQQEKFVGSTRYAP 1313
                                 :....|.|.:....||....|.|:.|||:|...:..||.:.:||
 Frog   877 ---------------------IGAQFKIEVDEGFCSPKPSEIKDFSYVYKPETCQVLVGCSMFAP 920

  Fly  1314 LTNLPSQTQPPLTLPTGCFYQPTWSSHK------------SRAATLAKAAAAQQQQHQKHQALQQ 1366
            |..||||..|.:.||..|.|:|:|:..|            .:...:....:|..|.:.:....|.
 Frog   921 LRTLPSQCLPGIKLPEDCIYRPSWTVGKLELIPPVPSMPFIKDGNIPSVGSAMDQDYVQTYTPQT 985

  Fly  1367 RIQLHQQKLQQLQLQNQQQQQAAAAAAAAASGGVGHQKHQHQHLHDLL--SAAPR----TPLTPS 1425
            ....                 ..:.:|..::||.|           :|  .|.||    ||.||.
 Frog   986 HTPF-----------------GMSNSAPPSNGGAG-----------ILPSPATPRFSAPTPRTPR 1022

  Fly  1426 TVPQPLSSGGSQYLLNQLNCPQAPPGASMQQLMHRAGMSPISPGPGMGPYAARSSPMSRATPTHP 1490
            |                   |:.|.|                   |.||.:.:.|
 Frog  1023 T-------------------PRTPRG-------------------GGGPASVQGS---------- 1039

  Fly  1491 PPPYPYDLA-VASPATSTSSYLNRPLHSQEHPHMHGLGGGATGVVGHGTGGGGHMGMVAYTGDAG 1554
               ..||.: :.|||::.|:.  |||:|.|
 Frog  1040 ---VKYDNSDLYSPASTPSTC--RPLNSVE----------------------------------- 1064

  Fly  1555 IVSGGTAMAAGSSSLLQELPEVNSVLVNILLYDTALNVFRDHNFDSSSVCVCNADTQKIGNIRGA 1619
                        .:.:..:||.:|:.||::|.::.:|:|:|.||||..:||||.      ||:||
 Frog  1065 ------------PATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNM------NIKGA 1111

  Fly  1620 DSGVYVPLPGVSFNPFPSGAGGALAGQRMLNGPSSAGFGGMRMISAFGGSPASASMPGAGSGHGH 1684
            |.|||:|
 Frog  1112 DVGVYIP---------------------------------------------------------- 1118

  Fly  1685 GPNGGSNSSSCTPPSSNPHITGYVDDDPVE-----CTCGFSAVVNRRLSHRAGLFYEDEVEITGI 1744
                                      ||.:     ||||||||:||:..:.:|||.|||::|.|.
 Frog  1119 --------------------------DPTQEVQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGR 1157

  Fly  1745 ADDPGRNKQPTLLSIIQSLSRKNQNKQGPGETSSALDKIGAGGLPNGQL---EQLGHAVFDLLLD 1806
            ..|.|:                        |.....:.:.|.|..:|.|   |::...:..||.|
 Frog  1158 HTDSGK------------------------EVEKRFEALRAAGGDHGVLRDPEKMPDELILLLHD 1198

  Fly  1807 QCSIIQTSSSSVHRALQSHRRRMSRQRRIFGNNGAPTASLASIANVLEFMDAHDVISLALEQSRL 1871
            ||:.:.:...::.:...:....:|...|:                  |..|..:...||||..|
 Frog  1199 QCTNLFSPFGTLDQEPITKTSTVSYSARV------------------EEQDCCNDCYLALEHGR- 1244

  Fly  1872 AFENQRMDNMMDFHGNGSSSSHQQQQLTAFHAPPPALRHKLAGIGAGRLTVHKWPYLPVGFTRSN 1936
                |.||||     :|........:.|.                     :|:|       ::.|
 Frog  1245 ----QFMDNM-----SGGKVDEALVKSTC---------------------LHRW-------SKRN 1272

  Fly  1937 ---------KEIVRTMNAIQPMLQNAFHCKSRGGSGSKDASSYNTVSGPLTWRQFHRLAGRAS-- 1990
                     ::|:|.:.::||:||:|...|       :...|:. |.|||||:|||::|||.|
 Frog  1273 AVDASMQCSQDILRMLLSLQPVLQDAVQKK-------RTVRSWG-VQGPLTWQQFHKMAGRGSYG 1329

  Fly  1991 --GQCEPQPIPSVVVGYEKDWISVAPHSIHYWDKFLLEPYSYARDVVYVVVCPDNEHVVNCTRSY 2053
              ...||.|||:.:|||:.|::.::|.::.||::.:|||:...||:.||||||:||.::|..:|:
 Frog  1330 TDESPEPLPIPTFLVGYDYDFLVLSPFALPYWERLMLEPFGSQRDIAYVVVCPENEALLNGAKSF 1394

  Fly  2054 FRELSSTYEMCKLGKHTPI--RGWDGFLQVGAARNNVPADRETTPLDDWLRTL--EHAALAEQIR 2114
            ||:|::.||.|:||:|..|  :..||.::||:......:::   |:.:|....  .::....::|
 Frog  1395 FRDLTAMYESCRLGQHRAISKQLTDGIMKVGSTAAKKLSEK---PVAEWFSQAINGNSEAYSKLR 1456

  Fly  2115 RYAVAFIHQLAPYLSRVPNDKTLLNPPD-------------------GSGNSHSKGGSSCSSNSS 2160
            .||....::|.|||:..|.|.:||..|:                   |:.::.|...||.:::||
 Frog  1457 LYAQVCRYELGPYLASQPLDSSLLCQPNLTSSASQTVSVQPAAASTPGNPSTPSSLNSSAANSSS 1521

  Fly  2161 SV----------------SGLPGG---DLPTD-----NIKLEPGTEP-QVQPMETNE-------- 2192
            :|                |.:.||   :.||.     ||...|.:.| ||..:::|:
 Frog  1522 TVTPNTLPQAAATGSAATSNVAGGLTANKPTSFPPYGNINSTPNSIPAQVNSVQSNQGGPQTQQQ 1586

  Fly  2193 -IKQEPGVGK-----GGTAAGETKPTLILGDPLGM---GETLEDINPSAIVLYVVNPFTFAS--D 2246
             ::|..|:..     ...||.|...:.:..|.:|:   ||:.....|.|||:|:|:|||:.|  :
 Frog  1587 TLQQNSGMSSEQSAAAAAAAAEVTESTMDRDKVGVPTDGESHAVTYPPAIVVYIVDPFTYESKDE 1651

  Fly  2247 SCELERLALIALLRCYAELLKAVPDSVRSQMNIQIISLESVMELGPCGNRKRFSDEIRCLALNIF 2311
            ......:.::.||||:.|:|..:|..:|:.:::||:..:..::.....:|:.::..::.||.::|
 Frog  1652 DSNSSSVWMLGLLRCFLEMLHILPPHLRNTVSVQIVPCQYFLQPVRQEDRQIYTQHLKSLAFSVF 1716

  Fly  2312 SQCRRHLVHAQSVKSLTGFGTAANMEAFLKTKDEPNRRAYKMYTAPFVLAPMHERNDKTDFSRSA 2376
            :||||.|..:.:||:|||||....:|..||:.:.|:  ..::||.||:|||:.::..:      .
 Frog  1717 TQCRRPLPASTNVKTLTGFGPGLAIENALKSPERPD--CIRLYTPPFILAPVKDKQTE------L 1773

  Fly  2377 GSMHGQNEHRYSVMYCNYCLSEDQAWLLATATDERGEMLEKICINIDVPNRARRRKAPARYVALK 2441
            |...|:...:|:|::..||||.||.||||:.||..||:||...|||||||||||:|..||...|:
 Frog  1774 GETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGELLETCIINIDVPNRARRKKGSARRCGLQ 1838

  Fly  2442 KLMDFIMGIISQTSQMWRLVIGRIGRIGHSELKSWSFLLSKQQLQKASKQFKDMCKQCTLMY--P 2504
            ||.::..|::..:|..||:||||:|||||.|||.||.|||::.||..||:.||||:.|.:..  .
 Frog  1839 KLWEWCQGLVQMSSVPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADS 1903

  Fly  2505 PTILSACLVTLEPDAKLRVMPDQFTPDERFSQ---ISMQ-NPLATPQDVTCTHILVFPTSAVCAP 2565
            |:|||||||.:||.....:|||..:....|.:   :::| :.|.||||.:|||||||||||....
 Frog  1904 PSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLTIQTSQLNTPQDTSCTHILVFPTSASVQV 1968

  Fly  2566 FTRQFQNEPQVDDDFLTFEEEGNEDFSDA-------DIGDLFWDTHMDRVSN----------HGS 2613
            .:..:..| .:|..|.|     |.|.:|.       |.||   |...|.::|          | |
 Frog  1969 ASATYTTE-NIDLAFNT-----NNDGADGMGIFDLLDTGD---DLDPDIINNLPTSPTGSQGH-S 2023

  Fly  2614 PGRMDDNRSWQSAGGNNFKCTPPQEVEEVGSLNQQPISVGYMVSTAPTGRMPAWFWSACPHLEDV 2678
            ||....:......|....:....:..:||.::.|||:::||.||||..|.:|.|||||||..::.
 Frog  2024 PGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQ 2088

  Fly  2679 CPVFLKTALHLHVPSIQSADDILNSTNAHQSGNDHPLDSNLTADVLRFVLEGYNALSWLALDSNT 2743
            ||:|||.:|||||||:|| |::|:|.::      ||||||.|:||||||||.|||||||..|..|
 Frog  2089 CPLFLKASLHLHVPSVQS-DELLHSKHS------HPLDSNQTSDVLRFVLEQYNALSWLTCDPAT 2146

  Fly  2744 HDRLSCLPINVQTLMDLY 2761
            .||.||||::...|..||
 Frog  2147 QDRRSCLPVHFVVLNQLY 2164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
skd	NP_730591.2	Med13_N	15..490	CDD:288451	147/500 (29%)
		Med13_C	2234..2755	CDD:283892	227/545 (42%)
med13	XP_004911678.1	Med13_N	14..385	CDD:288451	147/500 (29%)
		Med13_C	1637..2158	CDD:283892	227/545 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	336	1.000	Domainoid score	I1124
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21067
Inparanoid	1	1.050	900	1.000	Inparanoid score	I378
OMA	1	1.010	-	-		QHG46046
OrthoDB	1	1.010	-	-		D177884at2759
OrthoFinder	1	1.000	-	-		FOG0002706
OrthoInspector	1	1.000	-	-		otm48409
Panther	1	1.100	-	-	O	PTHR48249
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.170